ID  Q12063;
PN  Dehydrodolichyl diphosphate synthase complex subunit NUS1;
GN  NUS1;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Lipid droplet {ECO:0000269|PubMed:10515935, ECO:0000269|PubMed:11086160, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14690591}. Nucleus membrane {ECO:0000269|PubMed:14690591}; Single-pass membrane protein {ECO:0000305}.
DR  UNIPROT: Q12063;
DR  UNIPROT: D6VRG0;
DR  PDB: 6JCN;
DE  Function: With SRT1 or RER2, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). {ECO:0000269|PubMed:25066056}.
DE  Reference Proteome: Yes;
DE  Interaction: P40069; IntAct: EBI-16287555; Score: 0.35
DE  Interaction: P15108; IntAct: EBI-708615; Score: 0.56
DE  Interaction: P02829; IntAct: EBI-708618; Score: 0.40
DE  Interaction: P32589; IntAct: EBI-3727462; Score: 0.35
DE  Interaction: Q04432; IntAct: EBI-3830702; Score: 0.35
DE  Interaction: P53239; IntAct: EBI-16256836; Score: 0.00
DE  Interaction: P60010; IntAct: EBI-16287555; Score: 0.35
DE  Interaction: P05030; IntAct: EBI-16287555; Score: 0.35
DE  Interaction: P46970; IntAct: EBI-16287555; Score: 0.35
DE  Interaction: P15992; IntAct: EBI-16287555; Score: 0.35
DE  Interaction: P32836; IntAct: EBI-16287555; Score: 0.35
DE  Interaction: P32835; IntAct: EBI-16287555; Score: 0.35
DE  Interaction: P00950; IntAct: EBI-16287555; Score: 0.35
DE  Interaction: P33892; IntAct: EBI-16287555; Score: 0.35
DE  Interaction: P00830; IntAct: EBI-16287555; Score: 0.35
GO  GO:1904423;
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0016021;
GO  GO:0005811;
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0016765;
GO  GO:0019408;
GO  GO:0006486;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MPTMIKKDDKAMEPPNEKPHRKIERDDVPESSNHIPPPESGVLKGGKVNSKTRALKAVTSIIADADENPQKKVNNETNGV
SQ  QKQKTEDLSKRIGKFEYLFYKFLLVLLYICFGLFRYGQYQYNKMKLRIFSIIYNHAYTPQLIRQDVIPLKKIPKRLAAIL
SQ  EVKPVGDVGGGVTGLLNDASEIVCWTVSAGIKHLMLYDYDGILQRNVPELRMEIHSNLAKYFGPAHVPNYAVKIPHSNKI
SQ  FYNLDGIETETDVGNEIEANQEKDKIAIEISLLSNRDGRETIVDLTKTMAELCAVNELSVSDITMDLVDSELKQLVGPEP
SQ  DLLLYFGPSLDLQGFPPWHIRLTEFYWEKDNNEVIYSVFIRGLRQYAGCKVNVGK
//