ID  Q12912;
PN  Processed inositol 1,4,5-triphosphate receptor associated 2;
GN  IRAG2;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Comments: [Processed inositol 1,4,5-triphosphate receptor associated 2]: Cytoplasm {ECO:0000250|UniProtKB:Q60664}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q60664}; Single-pass type IV membrane protein {ECO:0000255}. Nucleus envelope {ECO:0000250|UniProtKB:Q60664}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q5RHB5}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q5RHB5}. Chromosome {ECO:0000250|UniProtKB:Q5RHB5}. Note=Colocalized with ITPR3 on the endoplasmic reticulum membrane. {ECO:0000250|UniProtKB:Q60664}.
DR  UNIPROT: Q12912;
DR  UNIPROT: A0AVM2;
DR  UNIPROT: B4E077;
DR  UNIPROT: Q8N301;
DR  Pfam: PF05781;
DR  OMIM: 602003;
DR  DisGeNET: 4033;
DE  Function: Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. {ECO:0000250|UniProtKB:Q60664}.
DE  Reference Proteome: Yes;
DE  Interaction: A0A6L7H2W2; IntAct: EBI-2839314; Score: 0.00
DE  Interaction: A0A6L8PL56; IntAct: EBI-2839333; Score: 0.00
DE  Interaction: A0A6L7HNZ8; IntAct: EBI-2839321; Score: 0.00
DE  Interaction: Q81JR3; IntAct: EBI-2839359; Score: 0.00
DE  Interaction: P62258; IntAct: EBI-3452822; Score: 0.00
DE  Interaction: Q9H4A3; IntAct: EBI-3453824; Score: 0.00
DE  Interaction: Q9ULV4; IntAct: EBI-20907264; Score: 0.40
DE  Interaction: P21709; IntAct: EBI-32720516; Score: 0.27
GO  GO:0035577;
GO  GO:0005694;
GO  GO:0005789;
GO  GO:0016021;
GO  GO:0005887;
GO  GO:0016020;
GO  GO:0005815;
GO  GO:0005635;
GO  GO:0005886;
GO  GO:0000922;
GO  GO:0008017;
GO  GO:0002376;
GO  GO:0006997;
GO  GO:0007338;
GO  GO:0006906;
GO  GO:0006903;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MESTPFSGVANQIHTLCERPTYGEVKDGALDVKRQHKCPGPTSGPSPGTNLSGCIRMNDDPSMEENGVERVCPESLLQSR
SQ  EYSSLPLPRHTSSTDGTITSSDPGLEILNMASCDLDRNSLCKKEEDTRSASPTIEAQGTSPAHDNIAFQDSTSKDKTILN
SQ  LEAKEEPETIEEHKKEHASGDSVVSPLPVTTVKSVNLRQSENTSANEKEVEAEFLRLSLGFKCDWFTLEKRVKLEERSRD
SQ  LAEENLKKEITNCLKLLESLTPLCEDDNQAQEIIKKLEKSIKFLSQCAARVASRAEMLGAINQESRVSKAVEVMIQHVEN
SQ  LKRMYAKEHAELEELKQVLLQNERSFNPLEDDDDCQIKKRSASLNSKPSSLRRVTIASLPRNIGNAGMVAGMENNDRFSR
SQ  RSSSWRILGSKQSEHRPSLPRFISTYSWADAEEEKCELKTKDDSEPSGEETVERTRKPSLSEKKNNPSKWDVSSVYDTIA
SQ  SWATNLKSSIRKANKALWLSIAFIVLFAALMSFLTGQLFQKSVDAAPTQQEDSWTSLEHILWPFTRLRHNGPPPV
//