ID  Q13023;
PN  A-kinase anchor protein 6;
GN  AKAP6;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Sarcoplasmic reticulum. Nucleus membrane. Note=In heart muscle. Participation of multiple targeting signals allow correct intracellular targeting. These may be repeated motifs rich in basic and hydrophobic amino acids, palmitoylated/myristoylated motifs or alternatively splice targeting sequences.
DR  UNIPROT: Q13023;
DR  UNIPROT: A7E242;
DR  UNIPROT: A7E2D4;
DR  UNIPROT: O15028;
DR  OMIM: 604691;
DR  DisGeNET: 9472;
DE  Function: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes.
DE  Reference Proteome: Yes;
DE  Interaction: P00519; IntAct: EBI-1957451; Score: 0.40
DE  Interaction: P12931; IntAct: EBI-1960946; Score: 0.40
DE  Interaction: Q06787; IntAct: EBI-21392373; Score: 0.00
DE  Interaction: Q96EV8; IntAct: EBI-1105409; Score: 0.00
DE  Interaction: P46108; IntAct: EBI-1959534; Score: 0.40
DE  Interaction: P06241; IntAct: EBI-1961210; Score: 0.40
DE  Interaction: P62993; IntAct: EBI-1964442; Score: 0.40
DE  Interaction: P16333; IntAct: EBI-1968724; Score: 0.40
DE  Interaction: P27986; IntAct: EBI-1970517; Score: 0.40
DE  Interaction: A0A6L8PLI9; IntAct: EBI-2838568; Score: 0.00
DE  Interaction: Q96CV9; IntAct: EBI-5357521; Score: 0.45
DE  Interaction: Q92736; IntAct: EBI-8758107; Score: 0.27
DE  Interaction: P14404; IntAct: EBI-21028244; Score: 0.35
DE  Interaction: Q99459; IntAct: EBI-21392414; Score: 0.00
DE  Interaction: Q9NRI5; IntAct: EBI-21392402; Score: 0.00
DE  Interaction: Q8TDR0; IntAct: EBI-21392387; Score: 0.00
GO  GO:0034704;
GO  GO:0005901;
GO  GO:0005737;
GO  GO:0014704;
GO  GO:0014701;
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0048471;
GO  GO:0016529;
GO  GO:0030315;
GO  GO:0008179;
GO  GO:0060090;
GO  GO:0051018;
GO  GO:0034237;
GO  GO:0043495;
GO  GO:0044325;
GO  GO:0001508;
GO  GO:0019933;
GO  GO:0071320;
GO  GO:0071345;
GO  GO:0070886;
GO  GO:0030307;
GO  GO:0061051;
GO  GO:1902261;
GO  GO:1901381;
GO  GO:0051281;
GO  GO:0060316;
GO  GO:0006605;
GO  GO:0060306;
GO  GO:0010738;
GO  GO:0010880;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MLTMSVTLSPLRSQDLDPMATDASPMAINMTPTVEQGEGEEAMKDMDSDQQYEKPPPLHTGADWKIVLHLPEIETWLRMT
SQ  SERVRDLTYSVQQDSDSKHVDVHLVQLKDICEDISDHVEQIHALLETEFSLKLLSYSVNVIVDIHAVQLLWHQLRVSVLV
SQ  LRERILQGLQDANGNYTRQTDILQAFSEETKEGRLDSLTEVDDSGQLTIKCSQNYLSLDCGITAFELSDYSPSEDLLSGL
SQ  GDMTSSQVKTKPFDSWSYSEMEKEFPELIRSVGLLTVAADSISTNGSEAVTEEVSQVSLSVDDKGGCEEDNASAVEEQPG
SQ  LTLGVSSSSGEALTNAAQPSSETVQQESSSSSHHDAKNQQPVPCENATPKRTIRDCFNYNEDSPTQPTLPKRGLFLKEET
SQ  FKNDLKGNGGKRQMVDLKPEMSRSTPSLVDPPDRSKLCLVLQSSYPNSPSAASQSYECLHKVGNGNLENTVKFHIKEISS
SQ  SLGRLNDCYKEKSRLKKPHKTSEEVPPCRTPKRGTGSGKQAKNTKSSAVPNGELSYTSKAIEGPQTNSASTSSLEPCNQR
SQ  SWNAKLQLQSETSSSPAFTQSSESSVGSDNIMSPVPLLSKHKSKKGQASSPSHVTRNGEVVEAWYGSDEYLALPSHLKQT
SQ  EVLALKLENLTKLLPQKPRGETIQNIDDWELSEMNSDSEIYPTYHVKKKHTRLGRVSPSSSSDIASSLGESIESGPLSDI
SQ  LSDEESSMPLAGMKKYADEKSERASSSEKNESHSATKSALIQKLMQDIQHQDNYEAIWEKIEGFVNKLDEFIQWLNEAME
SQ  TTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQHS
SQ  WILRALDTIKAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEFADMSKVHSVGSNG
SQ  LLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEKVDS
SQ  INEKWELLGKTLGEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFNSCLRQEKEGTMNTEKQL
SQ  QYFKSLCREIKQRRRGVASILRLCQHLLDDRETCNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESETLN
SQ  VIDPGLMDLNGMSEDALEWDEMDISNKLISLNEESNDLDQELQPVIPSLKLGETSNEDPGYDEEADNHGGSQYASNITAP
SQ  SSPHIYQVYSLHNVELYEDNHMPFLKNNPKVTGMTQPNVLTKSLSKDSSFSSTKSLPDLLGGSNLVKPCACHGGDMSQNS
SQ  GSESGIVSEGDTETTTNSEMCLLNAVDGSPSNLETEHLDPQMGDAVNVLKQKFTDEGESIKLPNSSQSSISPVGCVNGKV
SQ  GDLNSITKHTPDCLGEELQGKHDVFTFYDYSYLQGSKLKLPMIMKQSQSEKAHVEDPLLRGFYFDKKSCKSKHQTTELQP
SQ  DVPPHERILASASHEMDRISYKSGNIEKTFTGMQNAKQLSLLSHSSSIESLSPGGDLFGLGIFKNGSDSLQRSTSLESWL
SQ  TSYKSNEDLFSCHSSGDISVSSGSVGELSKRTLDLLNRLENIQSPSEQKIKRSVSDITLQSSSQKMSFTGQMSLDIASSI
SQ  NEDSAASLTELSSSDELSLCSEDIVLHKNKIPESNASFRKRLTRSVADESDVNVSMIVNVSCTSACTDDEDDSDLLSSST
SQ  LTLTEEELCIKDEDDDSSIATDDEIYEDCTLMSGLDYIKNELQTWIRPKLSLTRDKKRCNVSDEMKGSKDISSSEMTNPS
SQ  DTLNIETLLNGSVKRVSENNGNGKNSSHTHELGTKRENKKTIFKVNKDPYVADMENGNIEGIPERQKGKPNVTSKVSENL
SQ  GSHGKEISESEHCKCKALMDSLDDSNTAGKEFVSQDVRHLPKKCPNHHHFENQSTASTPTEKSFSELALETRFNNRQDSD
SQ  ALKSSDDAPSMAGKSAGCCLALEQNGTEENASISNISCCNCEPDVFHQKDAEDCSVHNFVKEIIDMASTALKSKSQPENE
SQ  VAAPTSLTQIKEKVLEHSHRPIQLRKGDFYSYLSLSSHDSDCGEVTNYIEEKSSTPLPLDTTDSGLDDKEDIECFFEACV
SQ  EGDSDGEEPCFSSAPPNESAVPSEAAMPLQATACSSEFSDSSLSADDADTVALSSPSSQERAEVGKEVNGLPQTSSGCAE
SQ  NLEFTPSKLDSEKESSGKPGESGMPEEHNAASAKSKVQDLSLKANQPTDKAALHPSPKTLTCEENLLNLHEKRHRNMHR
//