ID  Q13137;
PN  Calcium-binding and coiled-coil domain-containing protein 2;
GN  CALCOCO2;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000269|PubMed:12869526, ECO:0000269|PubMed:17635994, ECO:0000269|PubMed:9230084}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17635994}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:25771791}; Peripheral membrane protein {ECO:0000305}. Note=According to PubMed:7540613, localizes to nuclear dots. According to PubMed:9230084 and PubMed:12869526, it is not a nuclear dot-associated protein but localizes predominantly in the cytoplasm with a coarse-grained distribution preferentially close to the nucleus. {ECO:0000269|PubMed:12869526, ECO:0000269|PubMed:7540613, ECO:0000269|PubMed:9230084}.
DR  UNIPROT: Q13137;
DR  UNIPROT: B2RBT0;
DR  UNIPROT: B4DDC4;
DR  UNIPROT: B4DDT4;
DR  UNIPROT: B4DP36;
DR  UNIPROT: B4E0C0;
DR  UNIPROT: E7ENK0;
DR  UNIPROT: E7ETP5;
DR  UNIPROT: E9PBE5;
DR  UNIPROT: Q53FQ5;
DR  UNIPROT: Q53HB5;
DR  UNIPROT: Q6IBN9;
DR  UNIPROT: Q9BTF7;
DR  PDB: 2MXP;
DR  PDB: 3VVV;
DR  PDB: 3VVW;
DR  PDB: 4GXL;
DR  PDB: 4HAN;
DR  PDB: 4XKL;
DR  PDB: 5AAQ;
DR  PDB: 5Z7A;
DR  PDB: 5Z7L;
DR  PDB: 7EAA;
DR  Pfam: PF17751;
DR  PROSITE: PS51905;
DR  OMIM: 604587;
DR  DisGeNET: 10241;
DE  Function: Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994). {ECO:0000269|PubMed:17635994, ECO:0000269|PubMed:22246324, ECO:0000269|PubMed:23022382, ECO:0000269|PubMed:23386746, ECO:0000269|PubMed:25771791}.
DE  Reference Proteome: Yes;
DE  Interaction: O75604; IntAct: EBI-24334992; Score: 0.56
DE  Interaction: O75716; IntAct: EBI-10189253; Score: 0.56
DE  Interaction: P29991; IntAct: EBI-8829245; Score: 0.37
DE  Interaction: P50613; IntAct: EBI-21835901; Score: 0.35
DE  Interaction: Q02821; IntAct: EBI-11534474; Score: 0.56
DE  Interaction: Q06787; IntAct: EBI-6115370; Score: 0.55
DE  Interaction: Q9Y3C5; IntAct: EBI-7220121; Score: 0.37
DE  Interaction: Q96S44; IntAct: EBI-752485; Score: 0.74
DE  Interaction: O00214; IntAct: EBI-752575; Score: 0.85
DE  Interaction: Q53FD0; IntAct: EBI-752725; Score: 0.37
DE  Interaction: Q8N715; IntAct: EBI-752740; Score: 0.37
DE  Interaction: Q8TBB1; IntAct: EBI-753001; Score: 0.55
DE  Interaction: Q8N2W9; IntAct: EBI-753673; Score: 0.37
DE  Interaction: Q8N5R6; IntAct: EBI-753856; Score: 0.37
DE  Interaction: P25786; IntAct: EBI-753919; Score: 0.67
DE  Interaction: P26599; IntAct: EBI-754081; Score: 0.37
DE  Interaction: Q3YEC7; IntAct: EBI-754117; Score: 0.37
DE  Interaction: Q9UBL6; IntAct: EBI-24292126; Score: 0.56
DE  Interaction: Q96F93; IntAct: EBI-754906; Score: 0.37
DE  Interaction: Q9Y4Z0; IntAct: EBI-754981; Score: 0.78
DE  Interaction: P29353; IntAct: EBI-755236; Score: 0.55
DE  Interaction: P60520; IntAct: EBI-755311; Score: 0.78
DE  Interaction: Q15906; IntAct: EBI-755386; Score: 0.37
DE  Interaction: Q9Y4E5; IntAct: EBI-755704; Score: 0.37
DE  Interaction: Q9BQY9; IntAct: EBI-755827; Score: 0.37
DE  Interaction: Q14966; IntAct: EBI-755848; Score: 0.37
DE  Interaction: Q96D16; IntAct: EBI-755989; Score: 0.67
DE  Interaction: O95201; IntAct: EBI-756364; Score: 0.37
DE  Interaction: P51116; IntAct: EBI-756460; Score: 0.37
DE  Interaction: Q7L590; IntAct: EBI-756649; Score: 0.37
DE  Interaction: Q9UNA4; IntAct: EBI-756718; Score: 0.37
DE  Interaction: Q9UKA9; IntAct: EBI-756841; Score: 0.37
DE  Interaction: O95251; IntAct: EBI-757276; Score: 0.37
DE  Interaction: Q9BSM1; IntAct: EBI-757711; Score: 0.37
DE  Interaction: P56279; IntAct: EBI-757792; Score: 0.87
DE  Interaction: Q96GM5; IntAct: EBI-757918; Score: 0.67
DE  Interaction: Q8IYF1; IntAct: EBI-757939; Score: 0.55
DE  Interaction: O14639; IntAct: EBI-757951; Score: 0.37
DE  Interaction: Q13137; IntAct: EBI-758068; Score: 0.37
DE  Interaction: Q9H0I2; IntAct: EBI-758104; Score: 0.67
DE  Interaction: Q9BUY5; IntAct: EBI-758131; Score: 0.37
DE  Interaction: Q9BVV2; IntAct: EBI-758146; Score: 0.67
DE  Interaction: P30626; IntAct: EBI-758236; Score: 0.74
DE  Interaction: Q9BWD7; IntAct: EBI-758320; Score: 0.37
DE  Interaction: Q12933; IntAct: EBI-758476; Score: 0.37
DE  Interaction: Q9H9D4; IntAct: EBI-758947; Score: 0.67
DE  Interaction: Q15038; IntAct: EBI-759250; Score: 0.67
DE  Interaction: Q8TCX5; IntAct: EBI-759364; Score: 0.37
DE  Interaction: Q9UBV8; IntAct: EBI-759700; Score: 0.67
DE  Interaction: Q9UBZ4; IntAct: EBI-759748; Score: 0.37
DE  Interaction: Q9H0R8; IntAct: EBI-759847; Score: 0.78
DE  Interaction: O95990; IntAct: EBI-760045; Score: 0.37
DE  Interaction: Q7Z3B3; IntAct: EBI-760072; Score: 0.74
DE  Interaction: Q5NEX4; IntAct: EBI-2808427; Score: 0.00
DE  Interaction: A0A3N4B896; IntAct: EBI-2840104; Score: 0.00
DE  Interaction: Q9UNI6; IntAct: EBI-8633706; Score: 0.74
DE  Interaction: Q15884; IntAct: EBI-8636634; Score: 0.37
DE  Interaction: Q13671; IntAct: EBI-8641704; Score: 0.67
DE  Interaction: Q8WUI4; IntAct: EBI-10276459; Score: 0.56
DE  Interaction: Q99471; IntAct: EBI-8644653; Score: 0.67
DE  Interaction: Q6PF05; IntAct: EBI-8656859; Score: 0.37
DE  Interaction: Q86YD7; IntAct: EBI-8656891; Score: 0.78
DE  Interaction: P01106; IntAct: EBI-3962281; Score: 0.35
DE  Interaction: O43913; IntAct: EBI-3935022; Score: 0.37
DE  Interaction: P15927; IntAct: EBI-3935032; Score: 0.37
DE  Interaction: Q9Y4K3; IntAct: EBI-3935052; Score: 0.37
DE  Interaction: Q9Y6K9; IntAct: EBI-3935062; Score: 0.37
DE  Interaction: Q14161; IntAct: EBI-3935072; Score: 0.37
DE  Interaction: Q8TDY2; IntAct: EBI-3935082; Score: 0.37
DE  Interaction: Q15051; IntAct: EBI-4286917; Score: 0.35
DE  Interaction: Q7Z434; IntAct: EBI-6115370; Score: 0.58
DE  Interaction: Q8NCU4; IntAct: EBI-6115370; Score: 0.35
DE  Interaction: Q9UHD2; IntAct: EBI-6115370; Score: 0.75
DE  Interaction: P48634; IntAct: EBI-6115370; Score: 0.35
DE  Interaction: A7MCY6; IntAct: EBI-6115370; Score: 0.53
DE  Interaction: Q9H6S1; IntAct: EBI-6115370; Score: 0.53
DE  Interaction: Q9NVV4; IntAct: EBI-6115370; Score: 0.50
DE  Interaction: Q9QYP6; IntAct: EBI-6115837; Score: 0.35
DE  Interaction: Q99IB8; IntAct: EBI-6928172; Score: 0.37
DE  Interaction: Q9WMX2; IntAct: EBI-9081202; Score: 0.57
DE  Interaction: O41947; IntAct: EBI-9640332; Score: 0.37
DE  Interaction: A8KA13; IntAct: EBI-10174899; Score: 0.56
DE  Interaction: Q2TBE0; IntAct: EBI-10175027; Score: 0.56
DE  Interaction: B2R9Y1; IntAct: EBI-10175744; Score: 0.56
DE  Interaction: Q8WWY3; IntAct: EBI-10177378; Score: 0.72
DE  Interaction: O00560; IntAct: EBI-10180081; Score: 0.56
DE  Interaction: O43189; IntAct: EBI-10183509; Score: 0.56
DE  Interaction: O43324; IntAct: EBI-10183831; Score: 0.56
DE  Interaction: O43602; IntAct: EBI-10184475; Score: 0.56
DE  Interaction: O95363; IntAct: EBI-10191564; Score: 0.78
DE  Interaction: P00540; IntAct: EBI-10193294; Score: 0.78
DE  Interaction: P14678; IntAct: EBI-10198485; Score: 0.56
DE  Interaction: P17482; IntAct: EBI-10199927; Score: 0.56
DE  Interaction: P25791; IntAct: EBI-10202872; Score: 0.56
DE  Interaction: P26196; IntAct: EBI-10203823; Score: 0.72
DE  Interaction: P26640; IntAct: EBI-10204357; Score: 0.56
DE  Interaction: P32969; IntAct: EBI-10206135; Score: 0.56
DE  Interaction: P41227; IntAct: EBI-10208549; Score: 0.78
DE  Interaction: P49901; IntAct: EBI-10211623; Score: 0.56
DE  Interaction: P50539; IntAct: EBI-10212007; Score: 0.72
DE  Interaction: P51946; IntAct: EBI-10212597; Score: 0.56
DE  Interaction: P61968; IntAct: EBI-10218982; Score: 0.56
DE  Interaction: P62979; IntAct: EBI-10220080; Score: 0.56
DE  Interaction: Q02040; IntAct: EBI-10222670; Score: 0.56
DE  Interaction: Q05CH4; IntAct: EBI-10223754; Score: 0.56
DE  Interaction: Q08117; IntAct: EBI-10224979; Score: 0.56
DE  Interaction: Q12774; IntAct: EBI-10227037; Score: 0.56
DE  Interaction: Q14997; IntAct: EBI-10234580; Score: 0.56
DE  Interaction: Q14D33; IntAct: EBI-10234924; Score: 0.72
DE  Interaction: Q17RB8; IntAct: EBI-10238780; Score: 0.56
DE  Interaction: Q3B820; IntAct: EBI-10240301; Score: 0.72
DE  Interaction: Q5U5U6; IntAct: EBI-10247590; Score: 0.56
DE  Interaction: Q6NYC8; IntAct: EBI-10251814; Score: 0.56
DE  Interaction: Q6P4J0; IntAct: EBI-10252829; Score: 0.56
DE  Interaction: Q6PIY7; IntAct: EBI-10253897; Score: 0.56
DE  Interaction: Q7Z4I7; IntAct: EBI-10257703; Score: 0.56
DE  Interaction: Q86TG7; IntAct: EBI-10258559; Score: 0.67
DE  Interaction: Q86W54; IntAct: EBI-10259956; Score: 0.56
DE  Interaction: Q8IVS8; IntAct: EBI-10261677; Score: 0.56
DE  Interaction: Q8IYX8; IntAct: EBI-10264302; Score: 0.56
DE  Interaction: Q8N4T4; IntAct: EBI-10265711; Score: 0.67
DE  Interaction: Q8NBM4; IntAct: EBI-10269199; Score: 0.56
DE  Interaction: Q8TBE0; IntAct: EBI-10273199; Score: 0.56
DE  Interaction: Q8TBZ8; IntAct: EBI-10273829; Score: 0.56
DE  Interaction: Q8TES7; IntAct: EBI-10275340; Score: 0.56
DE  Interaction: Q8WU02; IntAct: EBI-10276217; Score: 0.56
DE  Interaction: Q8WXI9; IntAct: EBI-10278009; Score: 0.56
DE  Interaction: Q92567; IntAct: EBI-10278631; Score: 0.56
DE  Interaction: Q92608; IntAct: EBI-10278809; Score: 0.56
DE  Interaction: Q969Z0; IntAct: EBI-10281521; Score: 0.56
DE  Interaction: Q96A72; IntAct: EBI-10281716; Score: 0.72
DE  Interaction: Q96BZ8; IntAct: EBI-10282682; Score: 0.56
DE  Interaction: Q96C32; IntAct: EBI-10283082; Score: 0.56
DE  Interaction: Q96D03; IntAct: EBI-10284252; Score: 0.56
DE  Interaction: Q96T37; IntAct: EBI-10293900; Score: 0.56
DE  Interaction: Q99732; IntAct: EBI-10294748; Score: 0.72
DE  Interaction: Q9BU23; IntAct: EBI-10298573; Score: 0.56
DE  Interaction: Q9BV47; IntAct: EBI-10299234; Score: 0.56
DE  Interaction: Q9BXF9; IntAct: EBI-10301058; Score: 0.67
DE  Interaction: Q9BXY8; IntAct: EBI-10301594; Score: 0.56
DE  Interaction: Q9H7H0; IntAct: EBI-10308833; Score: 0.78
DE  Interaction: Q9HC52; IntAct: EBI-10310384; Score: 0.72
DE  Interaction: Q9NQT4; IntAct: EBI-10312366; Score: 0.56
DE  Interaction: Q9NU19; IntAct: EBI-10313689; Score: 0.56
DE  Interaction: Q9NX63; IntAct: EBI-10316161; Score: 0.56
DE  Interaction: Q9P0T4; IntAct: EBI-10317870; Score: 0.56
DE  Interaction: Q9P2K6; IntAct: EBI-10318921; Score: 0.56
DE  Interaction: Q9UIM3; IntAct: EBI-10322118; Score: 0.56
DE  Interaction: Q9UJV3; IntAct: EBI-10322427; Score: 0.56
DE  Interaction: Q9UJW0; IntAct: EBI-10322497; Score: 0.56
DE  Interaction: Q9UMS0; IntAct: EBI-10324153; Score: 0.56
DE  Interaction: Q9Y3M9; IntAct: EBI-10327900; Score: 0.56
DE  Interaction: Q9Y4X0; IntAct: EBI-10328456; Score: 0.67
DE  Interaction: P30566; IntAct: EBI-21246927; Score: 0.37
DE  Interaction: Q9HBZ2; IntAct: EBI-21247102; Score: 0.37
DE  Interaction: X5DP31; IntAct: EBI-21247566; Score: 0.37
DE  Interaction: X5D7R7; IntAct: EBI-21250303; Score: 0.37
DE  Interaction: X5DP17; IntAct: EBI-21250609; Score: 0.37
DE  Interaction: Q99608; IntAct: EBI-21250960; Score: 0.37
DE  Interaction: O43741; IntAct: EBI-21251734; Score: 0.37
DE  Interaction: P03182; IntAct: EBI-11721938; Score: 0.35
DE  Interaction: P30119; IntAct: EBI-11736591; Score: 0.37
DE  Interaction: P05759; IntAct: EBI-11522944; Score: 0.56
DE  Interaction: P0CH08; IntAct: EBI-11523121; Score: 0.56
DE  Interaction: P32902; IntAct: EBI-11526925; Score: 0.56
DE  Interaction: P38815; IntAct: EBI-11529521; Score: 0.56
DE  Interaction: P39518; IntAct: EBI-11529902; Score: 0.56
DE  Interaction: P40302; IntAct: EBI-11530551; Score: 0.56
DE  Interaction: P40325; IntAct: EBI-11530725; Score: 0.56
DE  Interaction: P41911; IntAct: EBI-11531747; Score: 0.56
DE  Interaction: Q06630; IntAct: EBI-11535826; Score: 0.56
DE  Interaction: Q06707; IntAct: EBI-11535920; Score: 0.56
DE  Interaction: Q07821; IntAct: EBI-11536127; Score: 0.56
DE  Interaction: Q12342; IntAct: EBI-11537295; Score: 0.56
DE  Interaction: P28702; IntAct: EBI-16433077; Score: 0.56
DE  Interaction: A0A0S2Z4M1; IntAct: EBI-16433037; Score: 0.56
DE  Interaction: O15169; IntAct: EBI-16433027; Score: 0.56
DE  Interaction: A0A0S2Z5X4; IntAct: EBI-16433137; Score: 0.56
DE  Interaction: Q3SY00; IntAct: EBI-24288555; Score: 0.56
DE  Interaction: P57086; IntAct: EBI-24289178; Score: 0.56
DE  Interaction: P47897; IntAct: EBI-24292527; Score: 0.56
DE  Interaction: Q7L5A3; IntAct: EBI-24308054; Score: 0.56
DE  Interaction: Q5JVL4; IntAct: EBI-24316916; Score: 0.56
DE  Interaction: P56524; IntAct: EBI-24325092; Score: 0.56
DE  Interaction: Q9P1Z0; IntAct: EBI-24331244; Score: 0.56
DE  Interaction: Q96HB5; IntAct: EBI-24332120; Score: 0.56
DE  Interaction: P54646; IntAct: EBI-24338182; Score: 0.56
DE  Interaction: Q9BSH4; IntAct: EBI-24338552; Score: 0.56
DE  Interaction: Q96FJ0; IntAct: EBI-25243983; Score: 0.56
DE  Interaction: P51504; IntAct: EBI-24480415; Score: 0.56
DE  Interaction: Q8NE01; IntAct: EBI-24488458; Score: 0.56
DE  Interaction: Q8NA54; IntAct: EBI-24496225; Score: 0.56
DE  Interaction: Q14005; IntAct: EBI-24503792; Score: 0.56
DE  Interaction: Q96IQ9; IntAct: EBI-24507508; Score: 0.56
DE  Interaction: Q494U1; IntAct: EBI-24374123; Score: 0.56
DE  Interaction: Q9BWG6; IntAct: EBI-24383955; Score: 0.56
DE  Interaction: Q6NX45; IntAct: EBI-24388156; Score: 0.56
DE  Interaction: Q6VB84; IntAct: EBI-24390683; Score: 0.56
DE  Interaction: Q9C0A6; IntAct: EBI-24391757; Score: 0.56
DE  Interaction: O00311; IntAct: EBI-24403310; Score: 0.56
DE  Interaction: P08218; IntAct: EBI-24406407; Score: 0.56
DE  Interaction: P09067; IntAct: EBI-24427120; Score: 0.56
DE  Interaction: Q5T619; IntAct: EBI-24430220; Score: 0.56
DE  Interaction: Q9H7X3; IntAct: EBI-24432271; Score: 0.56
DE  Interaction: Q6PF15; IntAct: EBI-24453693; Score: 0.56
DE  Interaction: Q9BXW4; IntAct: EBI-24455075; Score: 0.56
DE  Interaction: Q99633; IntAct: EBI-24456947; Score: 0.56
DE  Interaction: P28676; IntAct: EBI-24461986; Score: 0.56
DE  Interaction: Q6IQ23; IntAct: EBI-16398399; Score: 0.35
DE  Interaction: Q53EZ4; IntAct: EBI-21572102; Score: 0.35
DE  Interaction: P0CG47; IntAct: EBI-21572102; Score: 0.35
DE  Interaction: Q3KP66; IntAct: EBI-21617875; Score: 0.35
DE  Interaction: Q9H7C4; IntAct: EBI-21702482; Score: 0.35
DE  Interaction: Q9BU40; IntAct: EBI-21739567; Score: 0.35
DE  Interaction: Q96DB2; IntAct: EBI-21787335; Score: 0.35
DE  Interaction: E9PKR8; IntAct: EBI-21872066; Score: 0.35
DE  Interaction: Q9UHQ4; IntAct: EBI-21883433; Score: 0.40
DE  Interaction: P29972; IntAct: EBI-21268671; Score: 0.37
DE  Interaction: Q9H788; IntAct: EBI-21268710; Score: 0.37
DE  Interaction: P15622; IntAct: EBI-21268658; Score: 0.37
DE  Interaction: Q96HA8; IntAct: EBI-21268697; Score: 0.37
DE  Interaction: P61417; IntAct: EBI-20817146; Score: 0.37
DE  Interaction: Q83DE4; IntAct: EBI-21285435; Score: 0.37
DE  Interaction: P21580; IntAct: EBI-20737339; Score: 0.35
DE  Interaction: Q9UKE5; IntAct: EBI-28946906; Score: 0.55
DE  Interaction: Q14296; IntAct: EBI-22127120; Score: 0.37
DE  Interaction: P0CG48; IntAct: EBI-22146758; Score: 0.37
DE  Interaction: Q92574; IntAct: EBI-26515497; Score: 0.37
DE  Interaction: Q8N612; IntAct: EBI-34574737; Score: 0.27
GO  GO:0005776;
GO  GO:0000421;
GO  GO:0005737;
GO  GO:0031410;
GO  GO:0005856;
GO  GO:0005829;
GO  GO:0043231;
GO  GO:0016020;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0016605;
GO  GO:0046872;
GO  GO:0042803;
GO  GO:1901098;
GO  GO:0034341;
GO  GO:0016032;
GO  GO:0098792;
TP  Membrane Topology: Peripheral; Source: UniProt - Curator Inference {ECO:0000305};
SQ  MEETIKDPPTSAVLLDHCHFSQVIFNSVEKFYIPGGDVTCHYTFTQHFIPRRKDWIGIFRVGWKTTREYYTFMWVTLPID
SQ  LNNKSAKQQEVQFKAYYLPKDDEYYQFCYVDEDGVVRGASIPFQFRPENEEDILVVTTQGEVEEIEQHNKELCKENQELK
SQ  DSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQ
SQ  EKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEII
SQ  CNALQRQKERLEGENDLLKRENSRLLSYMGLDFNSLPYQVPTSDEGGARQNPGLAYGNPYSGIQESSSPSPLSIKKCPIC
SQ  KADDICDHTLEQQQMQPLCFNCPICDKIFPATEKQIFEDHVFCHSL
//