ID  Q13530;
PN  Serine incorporator 3;
GN  SERINC3;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cell membrane {ECO:0000250|UniProtKB:Q86VE9}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9QZI9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9QZI9}. Cytoplasm, perinuclear region {ECO:0000305|PubMed:26416734}. Note=(Microbial infection) Upon HIV-1 infection, it is redirected to perinuclear region following interaction with HIV-1 Nef, excluding it from virions particles, thereby preventing subsequent antiviral defense activity (Probable). {ECO:0000305|PubMed:26416734}.
DR  UNIPROT: Q13530;
DR  UNIPROT: B4DUE9;
DR  UNIPROT: O43717;
DR  UNIPROT: Q9BR33;
DR  Pfam: PF03348;
DR  OMIM: 607165;
DR  DisGeNET: 10955;
DE  Function: Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734). {ECO:0000269|PubMed:26416733, ECO:0000269|PubMed:26416734}.
DE  Reference Proteome: Yes;
DE  Interaction: O15260; IntAct: EBI-1059797; Score: 0.00
DE  Interaction: P24390; IntAct: EBI-1059822; Score: 0.00
DE  Interaction: Q99623; IntAct: EBI-1061397; Score: 0.00
DE  Interaction: Q9P035; IntAct: EBI-1078346; Score: 0.00
DE  Interaction: P53985; IntAct: EBI-1081007; Score: 0.00
DE  Interaction: Q9Y277; IntAct: EBI-1082606; Score: 0.00
DE  Interaction: P33947; IntAct: EBI-1083230; Score: 0.00
DE  Interaction: Q9HAV4; IntAct: EBI-1085165; Score: 0.00
DE  Interaction: P45880; IntAct: EBI-1086232; Score: 0.00
DE  Interaction: P62841; IntAct: EBI-3915396; Score: 0.37
DE  Interaction: O95393; IntAct: EBI-3922519; Score: 0.37
DE  Interaction: A0A286YCX6; IntAct: EBI-11119288; Score: 0.35
DE  Interaction: P30556; IntAct: EBI-20802983; Score: 0.37
DE  Interaction: P14416; IntAct: EBI-20805908; Score: 0.37
DE  Interaction: Q13263; IntAct: EBI-20929800; Score: 0.40
DE  Interaction: P28799; IntAct: EBI-25860965; Score: 0.56
DE  Interaction: O43933; IntAct: EBI-25881831; Score: 0.56
DE  Interaction: O76024; IntAct: EBI-25898215; Score: 0.56
GO  GO:0000139;
GO  GO:0016021;
GO  GO:0016020;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0015194;
GO  GO:0051607;
GO  GO:0009597;
GO  GO:0045087;
GO  GO:0006564;
GO  GO:0006658;
GO  GO:1902237;
GO  GO:0006665;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MGAVLGVFSLASWVPCLCSGASCLLCSCCPNSKNSTVTRLIYAFILLLSTVVSYIMQRKEMETYLKKIPGFCEGGFKIHE
SQ  ADINADKDCDVLVGYKAVYRISFAMAIFFFVFSLLMFKVKTSKDLRAAVHNGFWFFKIAALIGIMVGSFYIPGGYFSSVW
SQ  FVVGMIGAALFILIQLVLLVDFAHSWNESWVNRMEEGNPRLWYAALLSFTSAFYILSIICVGLLYTYYTKPDGCTENKFF
SQ  ISINLILCVVASIISIHPKIQEHQPRSGLLQSSLITLYTMYLTWSAMSNEPDRSCNPNLMSFITRITAPTLAPGNSTAVV
SQ  PTPTPPSKSGSLLDSDNFIGLFVFVLCLLYSSIRTSTNSQVDKLTLSGSDSVILGDTTTSGASDEEDGQPRRAVDNEKEG
SQ  VQYSYSLFHLMLCLASLYIMMTLTSWYSPDAKFQSMTSKWPAVWVKISSSWVCLLLYVWTLVAPLVLTSRDFS
//