ID  Q13625;
PN  Apoptosis-stimulating of p53 protein 2;
GN  TP53BP2;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region. Nucleus. Note=Predominantly found in the perinuclear region. Some small fraction is nuclear. Sequester in the cytoplasm on overexpression of DDX42.
DR  UNIPROT: Q13625;
DR  UNIPROT: B4DG66;
DR  UNIPROT: Q12892;
DR  UNIPROT: Q86X75;
DR  UNIPROT: Q96KQ3;
DR  PDB: 1YCS;
DR  PDB: 2UWQ;
DR  PDB: 4A63;
DR  PDB: 4IRV;
DR  PDB: 6GHM;
DR  PDB: 6HKP;
DR  Pfam: PF12796;
DR  Pfam: PF00018;
DR  PROSITE: PS50297;
DR  PROSITE: PS50088;
DR  PROSITE: PS50002;
DR  OMIM: 602143;
DR  DisGeNET: 7159;
DE  Function: Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}.
DE  Reference Proteome: Yes;
DE  Interaction: O95996; IntAct: EBI-8830464; Score: 0.54
DE  Interaction: P10415; IntAct: EBI-15723849; Score: 0.65
DE  Interaction: P27958; IntAct: EBI-9389968; Score: 0.64
DE  Interaction: P29991; IntAct: EBI-8828390; Score: 0.37
DE  Interaction: P49790; IntAct: EBI-9688225; Score: 0.35
DE  Interaction: P61970; IntAct: EBI-9688225; Score: 0.35
DE  Interaction: P62826; IntAct: EBI-9692277; Score: 0.64
DE  Interaction: Q07817; IntAct: EBI-15723914; Score: 0.56
DE  Interaction: Q12840; IntAct: EBI-731035; Score: 0.00
DE  Interaction: P05067; IntAct: EBI-77660; Score: 0.58
DE  Interaction: P62136; IntAct: EBI-7267006; Score: 0.86
DE  Interaction: P68104; IntAct: EBI-731032; Score: 0.00
DE  Interaction: P21246; IntAct: EBI-731038; Score: 0.00
DE  Interaction: Q9BVJ6; IntAct: EBI-731041; Score: 0.00
DE  Interaction: Q13432; IntAct: EBI-731044; Score: 0.00
DE  Interaction: Q9BYC9; IntAct: EBI-733610; Score: 0.00
DE  Interaction: Q13107; IntAct: EBI-736082; Score: 0.00
DE  Interaction: O15265; IntAct: EBI-952468; Score: 0.00
DE  Interaction: P04637; IntAct: EBI-1026207; Score: 0.90
DE  Interaction: P46937; IntAct: EBI-6912563; Score: 0.78
DE  Interaction: P46936; IntAct: EBI-7804125; Score: 0.40
DE  Interaction: P63104; IntAct: EBI-7195756; Score: 0.67
DE  Interaction: P46108; IntAct: EBI-1960202; Score: 0.40
DE  Interaction: Q04917; IntAct: EBI-1644092; Score: 0.64
DE  Interaction: Q04206; IntAct: EBI-1749490; Score: 0.56
DE  Interaction: P35570; IntAct: EBI-1751169; Score: 0.57
DE  Interaction: P81122; IntAct: EBI-1751281; Score: 0.48
DE  Interaction: O08724; IntAct: EBI-1751296; Score: 0.35
DE  Interaction: O14654; IntAct: EBI-1751296; Score: 0.35
DE  Interaction: P35569; IntAct: EBI-1751450; Score: 0.52
DE  Interaction: Q13625; IntAct: EBI-7907803; Score: 0.62
DE  Interaction: P36873; IntAct: EBI-7908028; Score: 0.85
DE  Interaction: Q92843; IntAct: EBI-7908070; Score: 0.68
DE  Interaction: Q81ZG1; IntAct: EBI-2838000; Score: 0.00
DE  Interaction: Q14457; IntAct: EBI-3257986; Score: 0.35
DE  Interaction: P31016; IntAct: EBI-7966630; Score: 0.44
DE  Interaction: Q09472; IntAct: EBI-8632299; Score: 0.50
DE  Interaction: Q8IUQ4; IntAct: EBI-10261292; Score: 0.56
DE  Interaction: P67870; IntAct: EBI-7137665; Score: 0.37
DE  Interaction: Q13387; IntAct: EBI-7240832; Score: 0.37
DE  Interaction: P53350; IntAct: EBI-7314465; Score: 0.37
DE  Interaction: Q8NEY8; IntAct: EBI-7317291; Score: 0.37
DE  Interaction: Q8TEW0; IntAct: EBI-6911368; Score: 0.53
DE  Interaction: A6NKD9; IntAct: EBI-6911368; Score: 0.35
DE  Interaction: P41236; IntAct: EBI-6911368; Score: 0.35
DE  Interaction: O75901; IntAct: EBI-6911368; Score: 0.35
DE  Interaction: Q9H3G5; IntAct: EBI-6911368; Score: 0.35
DE  Interaction: P34932; IntAct: EBI-6911368; Score: 0.35
DE  Interaction: P62140; IntAct: EBI-6911368; Score: 0.67
DE  Interaction: Q8NHQ8; IntAct: EBI-6911368; Score: 0.53
DE  Interaction: Q92598; IntAct: EBI-6911368; Score: 0.35
DE  Interaction: Q02833; IntAct: EBI-6911368; Score: 0.35
DE  Interaction: Q15834; IntAct: EBI-6911368; Score: 0.35
DE  Interaction: P04083; IntAct: EBI-6911368; Score: 0.35
DE  Interaction: A6NK89; IntAct: EBI-6912271; Score: 0.35
DE  Interaction: P31946; IntAct: EBI-8796749; Score: 0.35
DE  Interaction: Q9Y2J4; IntAct: EBI-8797381; Score: 0.35
DE  Interaction: Q7TSJ6; IntAct: EBI-8798662; Score: 0.27
DE  Interaction: Q4VCS5; IntAct: EBI-8799893; Score: 0.27
DE  Interaction: Q9WMX2; IntAct: EBI-9082105; Score: 0.37
DE  Interaction: Q2TBE0; IntAct: EBI-10175037; Score: 0.56
DE  Interaction: Q8WWY3; IntAct: EBI-10177388; Score: 0.56
DE  Interaction: O14777; IntAct: EBI-10181501; Score: 0.56
DE  Interaction: P17031; IntAct: EBI-10199685; Score: 0.56
DE  Interaction: P40222; IntAct: EBI-10207929; Score: 0.56
DE  Interaction: P56279; IntAct: EBI-10215275; Score: 0.56
DE  Interaction: P57075; IntAct: EBI-10215824; Score: 0.56
DE  Interaction: P61968; IntAct: EBI-10219004; Score: 0.56
DE  Interaction: P62807; IntAct: EBI-10219796; Score: 0.56
DE  Interaction: P62875; IntAct: EBI-10219932; Score: 0.56
DE  Interaction: P62993; IntAct: EBI-10220253; Score: 0.56
DE  Interaction: Q86Y26; IntAct: EBI-10230509; Score: 0.56
DE  Interaction: Q494U1; IntAct: EBI-10241572; Score: 0.56
DE  Interaction: Q53HC0; IntAct: EBI-10242635; Score: 0.56
DE  Interaction: Q8N5A5; IntAct: EBI-10265979; Score: 0.56
DE  Interaction: Q8N5M1; IntAct: EBI-10266628; Score: 0.56
DE  Interaction: Q8NCE2; IntAct: EBI-10269256; Score: 0.56
DE  Interaction: Q92844; IntAct: EBI-10279575; Score: 0.56
DE  Interaction: Q96DC9; IntAct: EBI-10284602; Score: 0.56
DE  Interaction: Q96GG9; IntAct: EBI-10286368; Score: 0.56
DE  Interaction: Q9BUJ2; IntAct: EBI-10298924; Score: 0.56
DE  Interaction: Q9BUZ4; IntAct: EBI-10299140; Score: 0.56
DE  Interaction: Q9NU19; IntAct: EBI-10313701; Score: 0.56
DE  Interaction: Q9UBU9; IntAct: EBI-10319914; Score: 0.56
DE  Interaction: Q9UQB8; IntAct: EBI-10324972; Score: 0.56
DE  Interaction: Q9Y2D8; IntAct: EBI-10326054; Score: 0.56
DE  Interaction: Q96J02; IntAct: EBI-10635597; Score: 0.40
DE  Interaction: Q9BYG5; IntAct: EBI-11002976; Score: 0.35
DE  Interaction: Q9NPB6; IntAct: EBI-11011731; Score: 0.35
DE  Interaction: Q9JK83; IntAct: EBI-11052294; Score: 0.35
DE  Interaction: P46938; IntAct: EBI-11138299; Score: 0.35
DE  Interaction: O75665; IntAct: EBI-11365691; Score: 0.27
DE  Interaction: Q15154; IntAct: EBI-11366535; Score: 0.27
DE  Interaction: Q5BJF6; IntAct: EBI-11367291; Score: 0.27
DE  Interaction: Q5JU00; IntAct: EBI-11367780; Score: 0.27
DE  Interaction: Q6ZU80; IntAct: EBI-11370150; Score: 0.27
DE  Interaction: Q7Z7A1; IntAct: EBI-11371427; Score: 0.27
DE  Interaction: Q8N4C6; IntAct: EBI-11374469; Score: 0.27
DE  Interaction: Q8TES7; IntAct: EBI-11374846; Score: 0.27
DE  Interaction: Q96KN7; IntAct: EBI-11376202; Score: 0.27
DE  Interaction: Q96NL6; IntAct: EBI-11376636; Score: 0.27
DE  Interaction: Q96ST8; IntAct: EBI-11377220; Score: 0.27
DE  Interaction: Q9Y2I6; IntAct: EBI-11379511; Score: 0.27
DE  Interaction: O60308; IntAct: EBI-11380299; Score: 0.27
DE  Interaction: O94986; IntAct: EBI-11381405; Score: 0.27
DE  Interaction: Q5TB80; IntAct: EBI-11385924; Score: 0.27
DE  Interaction: Q66GS9; IntAct: EBI-11386281; Score: 0.27
DE  Interaction: Q68CZ1; IntAct: EBI-11386978; Score: 0.27
DE  Interaction: Q8IW35; IntAct: EBI-11391901; Score: 0.27
DE  Interaction: Q8N137; IntAct: EBI-11392655; Score: 0.27
DE  Interaction: Q8N960; IntAct: EBI-11393386; Score: 0.27
DE  Interaction: Q9C0F1; IntAct: EBI-11397104; Score: 0.27
DE  Interaction: Q9HC77; IntAct: EBI-11397411; Score: 0.27
DE  Interaction: Q15435; IntAct: EBI-12451625; Score: 0.51
DE  Interaction: O43295; IntAct: EBI-21563971; Score: 0.35
DE  Interaction: Q7Z4N8; IntAct: EBI-21583801; Score: 0.35
DE  Interaction: Q86YM7; IntAct: EBI-21671273; Score: 0.35
DE  Interaction: Q9UMS4; IntAct: EBI-21763056; Score: 0.35
DE  Interaction: Q96ES7; IntAct: EBI-21781962; Score: 0.35
DE  Interaction: Q96NE9; IntAct: EBI-21880697; Score: 0.35
DE  Interaction: P61981; IntAct: EBI-21905461; Score: 0.35
DE  Interaction: Q8N3R9; IntAct: EBI-21911830; Score: 0.35
DE  Interaction: Q9H3D4; IntAct: EBI-15685239; Score: 0.44
DE  Interaction: O15350; IntAct: EBI-15685344; Score: 0.44
DE  Interaction: P12830; IntAct: EBI-16124887; Score: 0.35
DE  Interaction: P35222; IntAct: EBI-16124887; Score: 0.58
DE  Interaction: Q05086; IntAct: EBI-16814851; Score: 0.35
DE  Interaction: P16403; IntAct: EBI-20919284; Score: 0.40
DE  Interaction: Q15149; IntAct: EBI-20926194; Score: 0.40
DE  Interaction: Q9NPJ6; IntAct: EBI-25472202; Score: 0.27
DE  Interaction: Q6NSK7; IntAct: EBI-21387894; Score: 0.00
DE  Interaction: P0DOF2; IntAct: EBI-25603126; Score: 0.35
DE  Interaction: F1PAA9; IntAct: EBI-27079701; Score: 0.27
DE  Interaction: P46934; IntAct: EBI-30832503; Score: 0.44
DE  Interaction: P11362; IntAct: EBI-32721578; Score: 0.27
GO  GO:0030054;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0042802;
GO  GO:0051059;
GO  GO:0002039;
GO  GO:0017124;
GO  GO:0007049;
GO  GO:0072332;
GO  GO:0045786;
GO  GO:1900119;
GO  GO:0007165;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MMPMFLTVYLSNNEQHFTEVPVTPETICRDVVDLCKEPGESDCHLAEVWCGSERPVADNERMFDVLQRFGSQRNEVRFFL
SQ  RHERPPGRDIVSGPRSQDPSLKRNGVKVPGEYRRKENGVNSPRMDLTLAELQEMASRQQQQIEAQQQLLATKEQRLKFLK
SQ  QQDQRQQQQVAEQEKLKRLKEIAENQEAKLKKVRALKGHVEQKRLSNGKLVEEIEQMNNLFQQKQRELVLAVSKVEELTR
SQ  QLEMLKNGRIDSHHDNQSAVAELDRLYKELQLRNKLNQEQNAKLQQQRECLNKRNSEVAVMDKRVNELRDRLWKKKAALQ
SQ  QKENLPVSSDGNLPQQAASAPSRVAAVGPYIQSSTMPRMPSRPELLVKPALPDGSLVIQASEGPMKIQTLPNMRSGAASQ
SQ  TKGSKIHPVGPDWSPSNADLFPSQGSASVPQSTGNALDQVDDGEVPLREKEKKVRPFSMFDAVDQSNAPPSFGTLRKNQS
SQ  SEDILRDAQVANKNVAKVPPPVPTKPKQINLPYFGQTNQPPSDIKPDGSSQQLSTVVPSMGTKPKPAGQQPRVLLSPSIP
SQ  SVGQDQTLSPGSKQESPPAAAVRPFTPQPSKDTLLPPFRKPQTVAASSIYSMYTQQQAPGKNFQQAVQSALTKTHTRGPH
SQ  FSSVYGKPVIAAAQNQQQHPENIYSNSQGKPGSPEPETEPVSSVQENHENERIPRPLSPTKLLPFLSNPYRNQSDADLEA
SQ  LRKKLSNAPRPLKKRSSITEPEGPNGPNIQKLLYQRTTIAAMETISVPSYPSKSASVTASSESPVEIQNPYLHVEPEKEV
SQ  VSLVPESLSPEDVGNASTENSDMPAPSPGLDYEPEGVPDNSPNLQNNPEEPNPEAPHVLDVYLEEYPPYPPPPYPSGEPE
SQ  GPGEDSVSMRPPEITGQVSLPPGKRTNLRKTGSERIAHGMRVKFNPLALLLDSSLEGEFDLVQRIIYEVDDPSLPNDEGI
SQ  TALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAAVFAMTYSDMQTAADKCEEMEEGY
SQ  TQCSQFLYGVQEKMGIMNKGVIYALWDYEPQNDDELPMKEGDCMTIIHREDEDEIEWWWARLNDKEGYVPRNLLGLYPRI
SQ  KPRQRSLA
//