ID  Q14203;
PN  Dynactin subunit 1;
GN  DCTN1;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:17828277}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17828277, ECO:0000269|PubMed:22777741, ECO:0000269|PubMed:25774020, ECO:0000269|PubMed:26972003}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:20719959, ECO:0000269|PubMed:23985322, ECO:0000269|PubMed:25774020}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:25774020}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:25774020}. Nucleus envelope {ECO:0000269|PubMed:20679239}. Cytoplasm, cell cortex {ECO:0000269|PubMed:22327364}. Note=Localizes to microtubule plus ends (PubMed:17828277, PubMed:22777741, PubMed:25774020). Localizes preferentially to the ends of tyrosinated microtubules (PubMed:26972003). Localization at centrosome is regulated by SLK- dependent phosphorylation (PubMed:23985322). Localizes to centrosome in a PARKDA-dependent manner (PubMed:20719959). Localizes to the subdistal appendage region of the centriole in a KIF3A-dependent manner (PubMed:23386061). PLK1-mediated phosphorylation at Ser-179 is essential for its localization in the nuclear envelope (PubMed:20679239). {ECO:0000269|PubMed:17828277, ECO:0000269|PubMed:20679239, ECO:0000269|PubMed:20719959, ECO:0000269|PubMed:22777741, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:23985322, ECO:0000269|PubMed:25774020, ECO:0000269|PubMed:26972003}.
DR  UNIPROT: Q14203;
DR  UNIPROT: A8MY36;
DR  UNIPROT: B4DM45;
DR  UNIPROT: E9PFS5;
DR  UNIPROT: E9PGE1;
DR  UNIPROT: G5E9H4;
DR  UNIPROT: O95296;
DR  UNIPROT: Q6IQ37;
DR  UNIPROT: Q9BRM9;
DR  UNIPROT: Q9UIU1;
DR  UNIPROT: Q9UIU2;
DR  PDB: 1TXQ;
DR  PDB: 2COY;
DR  PDB: 2HKN;
DR  PDB: 2HKQ;
DR  PDB: 2HL3;
DR  PDB: 2HL5;
DR  PDB: 2HQH;
DR  PDB: 3E2U;
DR  PDB: 3TQ7;
DR  Pfam: PF01302;
DR  Pfam: PF12455;
DR  PROSITE: PS00845;
DR  PROSITE: PS50245;
DR  OMIM: 105400;
DR  OMIM: 168605;
DR  OMIM: 601143;
DR  OMIM: 607641;
DR  DisGeNET: 1639;
DE  Function: Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020). {ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:23874158, ECO:0000269|PubMed:25185702, ECO:0000269|PubMed:25774020}.
DE  Disease: Neuronopathy, distal hereditary motor, 7B (HMN7B) [MIM:607641]: A neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs. {ECO:0000269|PubMed:12627231, ECO:0000269|PubMed:16505168, ECO:0000269|PubMed:19136952, ECO:0000269|PubMed:19279216, ECO:0000269|PubMed:22777741}. Note=The disease is caused by variants affecting the gene represented in this entry. Amyotrophic lateral sclerosis (ALS) [MIM:105400]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. {ECO:0000269|PubMed:15326253, ECO:0000269|PubMed:16240349}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry. Perry syndrome (PERRYS) [MIM:168605]: A neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, sleep disturbances, exhaustion and marked weight loss. Parkinsonism develops later and respiratory failure occurred terminally. {ECO:0000269|PubMed:19136952, ECO:0000269|PubMed:23874158, ECO:0000269|PubMed:24676999, ECO:0000269|PubMed:24881494, ECO:0000269|PubMed:25185702, ECO:0000269|PubMed:26972003}. Note=The disease is caused by variants affecting the gene represented in this entry.
DE  Reference Proteome: Yes;
DE  Interaction: O00423; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: O08788; IntAct: EBI-2561198; Score: 0.56
DE  Interaction: O15027; IntAct: EBI-11083608; Score: 0.35
DE  Interaction: P29991; IntAct: EBI-8829140; Score: 0.37
DE  Interaction: P43034; IntAct: EBI-11382201; Score: 0.48
DE  Interaction: P58546; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q9UBN7; IntAct: EBI-25840647; Score: 0.56
DE  Interaction: P42025; IntAct: EBI-367597; Score: 0.54
DE  Interaction: Q96KM6; IntAct: EBI-7216721; Score: 0.37
DE  Interaction: P18669; IntAct: EBI-736541; Score: 0.00
DE  Interaction: P30622; IntAct: EBI-15657003; Score: 0.76
DE  Interaction: P20340; IntAct: EBI-8604645; Score: 0.40
DE  Interaction: P49662; IntAct: EBI-1063339; Score: 0.00
DE  Interaction: P43360; IntAct: EBI-25840462; Score: 0.56
DE  Interaction: Q9H8T0; IntAct: EBI-1070932; Score: 0.00
DE  Interaction: P01106; IntAct: EBI-1072184; Score: 0.00
DE  Interaction: P62330; IntAct: EBI-1073142; Score: 0.00
DE  Interaction: P40337; IntAct: EBI-1073742; Score: 0.00
DE  Interaction: O14593; IntAct: EBI-1079448; Score: 0.00
DE  Interaction: Q9Y2Q3; IntAct: EBI-1080223; Score: 0.00
DE  Interaction: Q7L1Q6; IntAct: EBI-1082566; Score: 0.00
DE  Interaction: O76071; IntAct: EBI-1083392; Score: 0.00
DE  Interaction: Q9NRI5; IntAct: EBI-1105616; Score: 0.00
DE  Interaction: Q96G01; IntAct: EBI-7141949; Score: 0.43
DE  Interaction: P10636; IntAct: EBI-7637855; Score: 0.70
DE  Interaction: Q8NFJ9; IntAct: EBI-25840415; Score: 0.56
DE  Interaction: Q96RK4; IntAct: EBI-1805881; Score: 0.63
DE  Interaction: P54256; IntAct: EBI-8013384; Score: 0.65
DE  Interaction: P61164; IntAct: EBI-2559425; Score: 0.40
DE  Interaction: Q99KJ8; IntAct: EBI-2559460; Score: 0.56
DE  Interaction: Q9Z0Y1; IntAct: EBI-2560063; Score: 0.56
DE  Interaction: P47753; IntAct: EBI-2563793; Score: 0.40
DE  Interaction: Q0VEJ0; IntAct: EBI-2563897; Score: 0.40
DE  Interaction: Q99551; IntAct: EBI-2690077; Score: 0.00
DE  Interaction: A0JNT9; IntAct: EBI-7894392; Score: 0.43
DE  Interaction: Q921C5; IntAct: EBI-7894652; Score: 0.35
DE  Interaction: Q13573; IntAct: EBI-7950968; Score: 0.35
DE  Interaction: Q9JK25; IntAct: EBI-8098108; Score: 0.46
DE  Interaction: O14777; IntAct: EBI-8098382; Score: 0.45
DE  Interaction: P42224; IntAct: EBI-3451713; Score: 0.00
DE  Interaction: Q8TCX1; IntAct: EBI-8568044; Score: 0.46
DE  Interaction: O95817; IntAct: EBI-8568339; Score: 0.35
DE  Interaction: P31749; IntAct: EBI-7094924; Score: 0.37
DE  Interaction: Q16543; IntAct: EBI-7112856; Score: 0.37
DE  Interaction: Q6ZU52; IntAct: EBI-7140179; Score: 0.37
DE  Interaction: O14576; IntAct: EBI-25840452; Score: 0.56
DE  Interaction: P51955; IntAct: EBI-7257818; Score: 0.37
DE  Interaction: O60925; IntAct: EBI-7284860; Score: 0.37
DE  Interaction: P13929; IntAct: EBI-5658334; Score: 0.00
DE  Interaction: Q96S44; IntAct: EBI-5665262; Score: 0.00
DE  Interaction: P62136; IntAct: EBI-5564400; Score: 0.37
DE  Interaction: O75381; IntAct: EBI-5911953; Score: 0.35
DE  Interaction: P10209; IntAct: EBI-6509331; Score: 0.37
DE  Interaction: Q13618; IntAct: EBI-21329068; Score: 0.35
DE  Interaction: Q9Y496; IntAct: EBI-8847255; Score: 0.27
DE  Interaction: P28741; IntAct: EBI-8847318; Score: 0.40
DE  Interaction: P88996; IntAct: EBI-9641406; Score: 0.37
DE  Interaction: O41964; IntAct: EBI-9641478; Score: 0.37
DE  Interaction: Q14980; IntAct: EBI-10039064; Score: 0.27
DE  Interaction: Q14653; IntAct: EBI-11321946; Score: 0.35
DE  Interaction: P05412; IntAct: EBI-11324725; Score: 0.35
DE  Interaction: E9QKK1; IntAct: EBI-10995761; Score: 0.35
DE  Interaction: Q8R1Q8; IntAct: EBI-11000601; Score: 0.35
DE  Interaction: Q8VC57; IntAct: EBI-11027413; Score: 0.35
DE  Interaction: Q96H55; IntAct: EBI-11031416; Score: 0.35
DE  Interaction: P62627; IntAct: EBI-11032607; Score: 0.35
DE  Interaction: Q9WUM4; IntAct: EBI-11065690; Score: 0.35
DE  Interaction: Q8R5C5; IntAct: EBI-11073047; Score: 0.35
DE  Interaction: Q8CBY8; IntAct: EBI-11074062; Score: 0.35
DE  Interaction: Q9QZB9; IntAct: EBI-11074142; Score: 0.35
DE  Interaction: Q15691; IntAct: EBI-11091481; Score: 0.86
DE  Interaction: Q9WTI7; IntAct: EBI-11093786; Score: 0.35
DE  Interaction: P47755; IntAct: EBI-11117728; Score: 0.48
DE  Interaction: Q14134; IntAct: EBI-11137164; Score: 0.35
DE  Interaction: Q14204; IntAct: EBI-11148090; Score: 0.48
DE  Interaction: P14635; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q96T17; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q9BT25; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: P31930; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q3KQU3; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: O00139; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q9P0I2; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q9NQ86; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: P36776; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q99643; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q96GD4; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q9HAU0; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: P61019; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q08AD1; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q96R06; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q01130; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q96P70; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q9Y5Y2; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q15555; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q8WWK9; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: O75330; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q9BRR8; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q8WVK7; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q9NZ32; IntAct: EBI-11366138; Score: 0.62
DE  Interaction: P11137; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q8IWC1; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q9NYZ3; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q7Z460; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q9UJW0; IntAct: EBI-11366138; Score: 0.62
DE  Interaction: Q9UPY8; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q5SW79; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: O00487; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q8WU90; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q969S3; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q14847; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: P43897; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q9Y4F5; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: P50570; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q9ULD2; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: O95373; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q8N2U0; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q8IX90; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: O15075; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q15286; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: P51665; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q53H12; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q9H3G5; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q99733; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q86V48; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: P61163; IntAct: EBI-11366138; Score: 0.62
DE  Interaction: Q96K17; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q9HC35; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: O00399; IntAct: EBI-11366138; Score: 0.62
DE  Interaction: Q9Y4L1; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q49MG5; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q00610; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q8IYA6; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q9GZQ8; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q99848; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q66K74; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: P20290; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q13561; IntAct: EBI-11366138; Score: 0.62
DE  Interaction: O75935; IntAct: EBI-11366138; Score: 0.62
DE  Interaction: P61006; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q13423; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q9Y6M1; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q14244; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: O94905; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: P30419; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: P22570; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: P55209; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q9Y448; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q5JU00; IntAct: EBI-11367780; Score: 0.27
DE  Interaction: Q8N4C6; IntAct: EBI-11374469; Score: 0.27
DE  Interaction: Q8NBT2; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q6P1N0; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: P07203; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q99661; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q9BXJ9; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q9P1F3; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q5EBL8; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q9P289; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q92900; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q9Y5B9; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q96CT7; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q7Z4H7; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q9BX40; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q13409; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q9Y5A9; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: O76041; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q96GY0; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: P41227; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q7KZI7; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q9H6D7; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: O75122; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: O14640; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q8TAT6; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: P33981; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q5QJ74; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: P04083; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q9H4H8; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: O43663; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q2NL82; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q9H6S0; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q8N568; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q96BD8; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q9BYV8; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q9C0F1; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q5T5Y3; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q16718; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: E9PAV3; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q9NX55; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q9UHG0; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q9UNY4; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q9H7E2; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: P49458; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q9BWT3; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q9BYJ9; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q15058; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q96GA3; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q92974; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q15398; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q8NHV4; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q9Y3Y2; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q9P2B7; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q99871; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q9P270; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q86XJ1; IntAct: EBI-11382201; Score: 0.27
DE  Interaction: Q9BTE1; IntAct: EBI-21619572; Score: 0.35
DE  Interaction: H9XIJ5; IntAct: EBI-11514215; Score: 0.37
DE  Interaction: P47756; IntAct: EBI-12449631; Score: 0.51
DE  Interaction: P52907; IntAct: EBI-12449631; Score: 0.51
DE  Interaction: Q9Y2I6; IntAct: EBI-12451292; Score: 0.35
DE  Interaction: G3G960; IntAct: EBI-11688985; Score: 0.40
DE  Interaction: Q9UQM7; IntAct: EBI-11913229; Score: 0.00
DE  Interaction: Q8N157; IntAct: EBI-11922091; Score: 0.00
DE  Interaction: Q16082; IntAct: EBI-15187599; Score: 0.37
DE  Interaction: P02511; IntAct: EBI-15187643; Score: 0.37
DE  Interaction: Q3KP66; IntAct: EBI-21617875; Score: 0.35
DE  Interaction: Q99797; IntAct: EBI-21619572; Score: 0.35
DE  Interaction: Q6XUX3; IntAct: EBI-21619572; Score: 0.35
DE  Interaction: P62736; IntAct: EBI-21619572; Score: 0.35
DE  Interaction: D6R9G5; IntAct: EBI-21619572; Score: 0.35
DE  Interaction: Q96MC5; IntAct: EBI-21663233; Score: 0.35
DE  Interaction: Q86WX3; IntAct: EBI-21663135; Score: 0.35
DE  Interaction: Q9NPQ8; IntAct: EBI-21663468; Score: 0.35
DE  Interaction: Q9GZP0; IntAct: EBI-21663347; Score: 0.35
DE  Interaction: Q13748; IntAct: EBI-15642149; Score: 0.44
DE  Interaction: Q9UNH7; IntAct: EBI-16042701; Score: 0.50
DE  Interaction: O95219; IntAct: EBI-16042750; Score: 0.35
DE  Interaction: Q08345; IntAct: EBI-22227061; Score: 0.35
DE  Interaction: A2A935; IntAct: EBI-21024514; Score: 0.35
DE  Interaction: P14404; IntAct: EBI-21026252; Score: 0.35
DE  Interaction: Q5S007; IntAct: EBI-21360986; Score: 0.35
DE  Interaction: Q9NQ75; IntAct: EBI-21373041; Score: 0.00
DE  Interaction: Q9Y5K6; IntAct: EBI-21373015; Score: 0.00
DE  Interaction: Q9UKE5; IntAct: EBI-21373000; Score: 0.00
DE  Interaction: O84166; IntAct: EBI-22302598; Score: 0.35
DE  Interaction: P0DOF2; IntAct: EBI-25603126; Score: 0.35
DE  Interaction: P0DTC6; IntAct: EBI-26495724; Score: 0.35
DE  Interaction: P18847; IntAct: EBI-25840405; Score: 0.56
DE  Interaction: O15392; IntAct: EBI-25840395; Score: 0.56
DE  Interaction: P63010; IntAct: EBI-25840385; Score: 0.56
DE  Interaction: O60479; IntAct: EBI-25840435; Score: 0.56
DE  Interaction: P42574; IntAct: EBI-25840425; Score: 0.56
DE  Interaction: Q9ULX5; IntAct: EBI-25840575; Score: 0.56
DE  Interaction: Q8WUW1; IntAct: EBI-25840565; Score: 0.56
DE  Interaction: P62987; IntAct: EBI-25840555; Score: 0.56
DE  Interaction: Q15554; IntAct: EBI-25840542; Score: 0.56
DE  Interaction: P19474; IntAct: EBI-25840525; Score: 0.56
DE  Interaction: Q92834; IntAct: EBI-25840515; Score: 0.56
DE  Interaction: P17980; IntAct: EBI-25840505; Score: 0.56
DE  Interaction: Q9BR81; IntAct: EBI-25840495; Score: 0.56
DE  Interaction: O15381; IntAct: EBI-25840483; Score: 0.56
DE  Interaction: Q6NXG1; IntAct: EBI-25840813; Score: 0.56
DE  Interaction: Q9H0E2; IntAct: EBI-25840803; Score: 0.56
DE  Interaction: P57075; IntAct: EBI-25840793; Score: 0.56
DE  Interaction: Q96RL1; IntAct: EBI-25840783; Score: 0.56
DE  Interaction: O95777; IntAct: EBI-25840771; Score: 0.56
DE  Interaction: Q04323; IntAct: EBI-25840761; Score: 0.56
DE  Interaction: Q9UJ41; IntAct: EBI-25840749; Score: 0.56
DE  Interaction: Q9Y2M5; IntAct: EBI-25840739; Score: 0.56
DE  Interaction: Q99932; IntAct: EBI-25840729; Score: 0.56
DE  Interaction: Q96EK5; IntAct: EBI-25840719; Score: 0.56
DE  Interaction: Q8N488; IntAct: EBI-25840708; Score: 0.56
DE  Interaction: O00308; IntAct: EBI-25840688; Score: 0.56
DE  Interaction: Q15436; IntAct: EBI-25840677; Score: 0.56
DE  Interaction: Q9BSL1; IntAct: EBI-25840667; Score: 0.56
DE  Interaction: O75886; IntAct: EBI-25840657; Score: 0.56
DE  Interaction: Q6DN90; IntAct: EBI-25840625; Score: 0.56
DE  Interaction: Q9UHY8; IntAct: EBI-25840615; Score: 0.56
DE  Interaction: O95671; IntAct: EBI-25840605; Score: 0.56
DE  Interaction: Q9UNS2; IntAct: EBI-25840595; Score: 0.56
DE  Interaction: P46379; IntAct: EBI-25840585; Score: 0.56
DE  Interaction: Q6ZTN6; IntAct: EBI-25840998; Score: 0.56
DE  Interaction: Q8NBM4; IntAct: EBI-25840983; Score: 0.56
DE  Interaction: Q8TC29; IntAct: EBI-25840966; Score: 0.56
DE  Interaction: Q8IYW5; IntAct: EBI-25840956; Score: 0.56
DE  Interaction: Q96D59; IntAct: EBI-25840946; Score: 0.56
DE  Interaction: Q8WVJ9; IntAct: EBI-25840936; Score: 0.56
DE  Interaction: Q9BYZ2; IntAct: EBI-25840926; Score: 0.56
DE  Interaction: Q8IY31; IntAct: EBI-25840916; Score: 0.56
DE  Interaction: Q8N594; IntAct: EBI-25840906; Score: 0.56
DE  Interaction: Q96JM7; IntAct: EBI-25840896; Score: 0.56
DE  Interaction: Q9GZS3; IntAct: EBI-25840886; Score: 0.56
DE  Interaction: Q71RG4; IntAct: EBI-25840876; Score: 0.56
DE  Interaction: A4FUJ8; IntAct: EBI-25840866; Score: 0.56
DE  Interaction: Q9HCE7; IntAct: EBI-25840856; Score: 0.56
DE  Interaction: Q6GQQ9; IntAct: EBI-25840844; Score: 0.56
DE  Interaction: Q96FW1; IntAct: EBI-25840833; Score: 0.56
DE  Interaction: Q9NV79; IntAct: EBI-25840823; Score: 0.56
DE  Interaction: P05067; IntAct: EBI-25938504; Score: 0.56
DE  Interaction: P51114; IntAct: EBI-26510253; Score: 0.37
DE  Interaction: P49639; IntAct: EBI-26512419; Score: 0.37
DE  Interaction: P13569; IntAct: EBI-27087549; Score: 0.35
DE  Interaction: Q12792; IntAct: EBI-28939213; Score: 0.35
DE  Interaction: Q8NCK7; IntAct: EBI-27103180; Score: 0.35
DE  Interaction: Q6ZMQ8; IntAct: EBI-32723474; Score: 0.27
GO  GO:0030424;
GO  GO:0005938;
GO  GO:0099738;
GO  GO:0031252;
GO  GO:0120103;
GO  GO:0005814;
GO  GO:0005813;
GO  GO:0036064;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0030286;
GO  GO:0045171;
GO  GO:0000776;
GO  GO:0016020;
GO  GO:0005874;
GO  GO:0005875;
GO  GO:0015630;
GO  GO:0035371;
GO  GO:0072686;
GO  GO:0043005;
GO  GO:0043025;
GO  GO:0005635;
GO  GO:0005634;
GO  GO:0005819;
GO  GO:0000922;
GO  GO:0008017;
GO  GO:0051010;
GO  GO:0019901;
GO  GO:0048156;
GO  GO:0015631;
GO  GO:0051301;
GO  GO:0010457;
GO  GO:0031122;
GO  GO:0000132;
GO  GO:0099558;
GO  GO:0032402;
GO  GO:0034454;
GO  GO:0000278;
GO  GO:0061744;
GO  GO:0007399;
GO  GO:0007528;
GO  GO:0050905;
GO  GO:0070050;
GO  GO:1990535;
GO  GO:1905515;
GO  GO:0051081;
GO  GO:0007097;
GO  GO:0090063;
GO  GO:0031116;
GO  GO:1904398;
GO  GO:0060236;
GO  GO:0042147;
GO  GO:0021517;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFT
SQ  CDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKREGTDTTAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGV
SQ  AGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAE
SQ  DKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAES
SQ  LQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQ
SQ  ELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARE
SQ  TELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFA
SQ  ETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERP
SQ  GLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPL
SQ  TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK
SQ  IRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGT
SQ  PSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLK
SQ  IKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQ
SQ  SKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMK
SQ  ASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVE
SQ  KLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRLIS
//