ID  Q14244;
PN  Ensconsin;
GN  MAP7;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region. Basolateral cell membrane. Cytoplasm, cytoskeleton. Note=Colocalized on microtubules. An intracellular redistribution is triggered during induction of keratinocyte terminal differentiation from microtubules with a perinuclear localization to cortical microtubules organized in spike- like bundles facing intercellular contacts.
DR  UNIPROT: Q14244;
DR  UNIPROT: B7Z290;
DR  UNIPROT: B7Z400;
DR  UNIPROT: B7Z5S7;
DR  UNIPROT: B7Z9U7;
DR  UNIPROT: C9JPS0;
DR  UNIPROT: E9PCP3;
DR  UNIPROT: F5H1E2;
DR  UNIPROT: Q7Z6S0;
DR  UNIPROT: Q8TAU5;
DR  UNIPROT: Q9NY82;
DR  UNIPROT: Q9NY83;
DR  Pfam: PF05672;
DR  OMIM: 604108;
DR  DisGeNET: 9053;
DE  Function: Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}.
DE  Reference Proteome: Yes;
DE  Interaction: K9N7C7; IntAct: EBI-26374923; Score: 0.35
DE  Interaction: O15027; IntAct: EBI-11083608; Score: 0.35
DE  Interaction: P59595; IntAct: EBI-27129966; Score: 0.35
DE  Interaction: Q14203; IntAct: EBI-11366138; Score: 0.27
DE  Interaction: Q00005; IntAct: EBI-2210942; Score: 0.46
DE  Interaction: P61457; IntAct: EBI-2688436; Score: 0.00
DE  Interaction: Q99459; IntAct: EBI-7954144; Score: 0.35
DE  Interaction: E9QKK1; IntAct: EBI-10995761; Score: 0.35
DE  Interaction: Q9D8B3; IntAct: EBI-11052854; Score: 0.35
DE  Interaction: P62714; IntAct: EBI-11056306; Score: 0.35
DE  Interaction: Q8TF05; IntAct: EBI-11056691; Score: 0.35
DE  Interaction: Q9Z2X1; IntAct: EBI-11066678; Score: 0.35
DE  Interaction: G3X972; IntAct: EBI-11079358; Score: 0.35
DE  Interaction: Q2KHM9; IntAct: EBI-11366777; Score: 0.27
DE  Interaction: Q86VQ0; IntAct: EBI-11372448; Score: 0.27
DE  Interaction: Q8N0Z3; IntAct: EBI-11392023; Score: 0.27
DE  Interaction: P54274; IntAct: EBI-11305425; Score: 0.37
DE  Interaction: Q9NUX5; IntAct: EBI-11305435; Score: 0.37
DE  Interaction: Q9Y3M2; IntAct: EBI-12449244; Score: 0.51
DE  Interaction: Q71U36; IntAct: EBI-11897791; Score: 0.35
DE  Interaction: Q8NC26; IntAct: EBI-23690200; Score: 0.56
DE  Interaction: Q6NSX1; IntAct: EBI-23766440; Score: 0.56
DE  Interaction: Q8N3C7; IntAct: EBI-24655058; Score: 0.56
DE  Interaction: A0A0H3JP21; IntAct: EBI-13947943; Score: 0.58
DE  Interaction: Q8XBX8; IntAct: EBI-13947961; Score: 0.59
DE  Interaction: Q9UN74; IntAct: EBI-21510494; Score: 0.35
DE  Interaction: Q9UGM1; IntAct: EBI-21517134; Score: 0.35
DE  Interaction: O60232; IntAct: EBI-21543889; Score: 0.35
DE  Interaction: Q8WVZ9; IntAct: EBI-21562457; Score: 0.35
DE  Interaction: Q96F46; IntAct: EBI-21578337; Score: 0.35
DE  Interaction: P05067; IntAct: EBI-21580477; Score: 0.35
DE  Interaction: O14595; IntAct: EBI-21619731; Score: 0.35
DE  Interaction: Q8N6Y1; IntAct: EBI-21628941; Score: 0.35
DE  Interaction: Q9Y5F2; IntAct: EBI-21658599; Score: 0.35
DE  Interaction: Q9Y5G8; IntAct: EBI-21697051; Score: 0.35
DE  Interaction: Q13557; IntAct: EBI-21719478; Score: 0.35
DE  Interaction: Q8N4J0; IntAct: EBI-21736494; Score: 0.35
DE  Interaction: P61981; IntAct: EBI-21905461; Score: 0.35
DE  Interaction: Q9ULK4; IntAct: EBI-25472850; Score: 0.35
DE  Interaction: Q86V81; IntAct: EBI-21258109; Score: 0.35
DE  Interaction: P03372; IntAct: EBI-21301141; Score: 0.35
DE  Interaction: O95273; IntAct: EBI-22130147; Score: 0.37
DE  Interaction: Q9ULX6; IntAct: EBI-26451653; Score: 0.35
DE  Interaction: Q92630; IntAct: EBI-28952196; Score: 0.27
DE  Interaction: P0DTC9; IntAct: EBI-27127583; Score: 0.35
DE  Interaction: P15130; IntAct: EBI-27131516; Score: 0.35
DE  Interaction: Q0ZME3; IntAct: EBI-27131755; Score: 0.35
DE  Interaction: Q6Q1R8; IntAct: EBI-27132003; Score: 0.35
DE  Interaction: K9N4V7; IntAct: EBI-27132270; Score: 0.35
DE  Interaction: P33469; IntAct: EBI-27132272; Score: 0.35
DE  Interaction: Q93009; IntAct: EBI-30842225; Score: 0.44
DE  Interaction: Q9UIH9; IntAct: EBI-29019642; Score: 0.35
DE  Interaction: Q9BXK1; IntAct: EBI-29019783; Score: 0.35
DE  Interaction: O95600; IntAct: EBI-29020196; Score: 0.35
GO  GO:0030424;
GO  GO:0016323;
GO  GO:0005829;
GO  GO:0005874;
GO  GO:0005875;
GO  GO:0015630;
GO  GO:0048471;
GO  GO:0005102;
GO  GO:0005198;
GO  GO:0007163;
GO  GO:0000226;
GO  GO:0072659;
GO  GO:0006970;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MAELGAGGDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQ
SQ  LAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRW
SQ  SWGGSLHGSPSIHSADPDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLARS
SQ  KSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTASYKKERERENVLFLTSGTRRAVSPSNPK
SQ  ARQPARSRLWLPSKSLPHLPGTPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKG
SQ  RAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEAT
SQ  RLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREE
SQ  AERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVS
SQ  ALPCTTNAPGNGKPVGSPHVVTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEIINLPIGSKPSRLDVTNSESPEIPLN
SQ  PILAFDDEGTLGPLPQVDGVQTQQTAEVI
//