ID  Q14542;
PN  Equilibrative nucleoside transporter 2;
GN  SLC29A2;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Basolateral cell membrane {ECO:0000269|PubMed:12527552}; Multi-pass membrane protein {ECO:0000269|PubMed:12527552}. Nucleus membrane {ECO:0000269|PubMed:12527552}; Multi-pass membrane protein {ECO:0000269|PubMed:12527552}. Note=Localized at the basolateral cell membrane in polarized MDCK cells.
DR  UNIPROT: Q14542;
DR  UNIPROT: B3KPY7;
DR  UNIPROT: O43530;
DR  UNIPROT: Q52M84;
DR  UNIPROT: Q96R00;
DR  UNIPROT: Q9UPE0;
DR  Pfam: PF01733;
DR  OMIM: 602110;
DR  DisGeNET: 3177;
DE  Function: Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine. {ECO:0000269|PubMed:9396714}.
DE  Reference Proteome: Yes;
DE  Interaction: O43889; IntAct: EBI-8649617; Score: 0.37
DE  Interaction: P60033; IntAct: EBI-25645944; Score: 0.35
GO  GO:0016323;
GO  GO:0005887;
GO  GO:0031965;
GO  GO:0005730;
GO  GO:0005886;
GO  GO:0098793;
GO  GO:0005326;
GO  GO:0005337;
GO  GO:0015211;
GO  GO:0015213;
GO  GO:0015853;
GO  GO:0032238;
GO  GO:0032869;
GO  GO:0015854;
GO  GO:0035344;
GO  GO:0007595;
GO  GO:0098810;
GO  GO:0006836;
GO  GO:0001504;
GO  GO:1901642;
GO  GO:0015858;
GO  GO:0015860;
GO  GO:0072531;
GO  GO:0035364;
GO  GO:0150104;
GO  GO:0015862;
GO  GO:0006855;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MARGDAPRDSYHLVGISFFILGLGTLLPWNFFITAIPYFQARLAGAGNSTARILSTNHTGPEDAFNFNNWVTLLSQLPLL
SQ  LFTLLNSFLYQCVPETVRILGSLLAILLLFALTAALVKVDMSPGPFFSITMASVCFINSFSAVLQGSLFGQLGTMPSTYS
SQ  TLFLSGQGLAGIFAALAMLLSMASGVDAETSALGYFITPCVGILMSIVCYLSLPHLKFARYYLANKSSQAQAQELETKAE
SQ  LLQSDENGIPSSPQKVALTLDLDLEKEPESEPDEPQKPGKPSVFTVFQKIWLTALCLVLVFTVTLSVFPAITAMVTSSTS
SQ  PGKWSQFFNPICCFLLFNIMDWLGRSLTSYFLWPDEDSRLLPLLVCLRFLFVPLFMLCHVPQRSRLPILFPQDAYFITFM
SQ  LLFAVSNGYLVSLTMCLAPRQVLPHEREVAGALMTFFLALGLSCGASLSFLFKALL
//