ID  Q14693;
PN  Phosphatidate phosphatase LPIN1;
GN  LPIN1;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Cytoplasm, cytosol {ECO:0000269|PubMed:29765047}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:29765047}. Nucleus membrane {ECO:0000250|UniProtKB:Q91ZP3}. Note=Translocates from the cytosol to the endoplasmic reticulum following acetylation by KAT5. {ECO:0000269|PubMed:29765047}.
DR  UNIPROT: Q14693;
DR  UNIPROT: A8MU38;
DR  UNIPROT: B4DET9;
DR  UNIPROT: B4DGS4;
DR  UNIPROT: B4DGZ6;
DR  UNIPROT: B5MC18;
DR  UNIPROT: B7Z858;
DR  UNIPROT: D6W506;
DR  UNIPROT: E7ESE7;
DR  UNIPROT: F5GY24;
DR  UNIPROT: Q53T25;
DR  Pfam: PF16876;
DR  Pfam: PF04571;
DR  Pfam: PF08235;
DR  OMIM: 268200;
DR  OMIM: 605518;
DR  DisGeNET: 23175;
DE  Function: Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis and therefore controls the metabolism of fatty acids at different levels (PubMed:20231281, PubMed:29765047). Is involved in adipocyte differentiation (By similarity). Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression (By similarity). Recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity). {ECO:0000250|UniProtKB:Q91ZP3, ECO:0000269|PubMed:20231281, ECO:0000269|PubMed:29765047}.
DE  Disease: Myoglobinuria, acute recurrent, autosomal recessive (ARARM) [MIM:268200]: Recurrent myoglobinuria is characterized by recurrent attacks of rhabdomyolysis (necrosis or disintegration of skeletal muscle) associated with muscle pain and weakness and followed by excretion of myoglobin in the urine. Renal failure may occasionally occur. {ECO:0000269|PubMed:18817903}. Note=The disease is caused by variants affecting the gene represented in this entry.
DE  Reference Proteome: Yes;
DE  Interaction: P12931; IntAct: EBI-25892196; Score: 0.56
DE  Interaction: Q00613; IntAct: EBI-25869697; Score: 0.56
DE  Interaction: Q00534; IntAct: EBI-5293262; Score: 0.44
DE  Interaction: Q8TEQ6; IntAct: EBI-11086338; Score: 0.35
DE  Interaction: Q6P5F9; IntAct: EBI-11603310; Score: 0.35
DE  Interaction: Q9BQK8; IntAct: EBI-21854905; Score: 0.35
DE  Interaction: P61981; IntAct: EBI-21905461; Score: 0.35
DE  Interaction: P62136; IntAct: EBI-16370519; Score: 0.35
DE  Interaction: P14625; IntAct: EBI-20905656; Score: 0.40
DE  Interaction: P62258; IntAct: EBI-25384933; Score: 0.35
DE  Interaction: P09172; IntAct: EBI-25840287; Score: 0.56
DE  Interaction: Q01658; IntAct: EBI-25845745; Score: 0.56
DE  Interaction: P21333; IntAct: EBI-25856444; Score: 0.56
DE  Interaction: P01100; IntAct: EBI-25856887; Score: 0.56
DE  Interaction: P50440; IntAct: EBI-25857412; Score: 0.56
DE  Interaction: P14136; IntAct: EBI-25858196; Score: 0.56
DE  Interaction: P62993; IntAct: EBI-25859867; Score: 0.56
DE  Interaction: P28799; IntAct: EBI-25861035; Score: 0.56
DE  Interaction: Q00403; IntAct: EBI-25865181; Score: 0.56
DE  Interaction: P04792; IntAct: EBI-25870897; Score: 0.56
DE  Interaction: O76024; IntAct: EBI-25898341; Score: 0.56
DE  Interaction: Q9Y5Q9; IntAct: EBI-25907060; Score: 0.56
DE  Interaction: O60333; IntAct: EBI-25915429; Score: 0.56
DE  Interaction: Q9UBB4; IntAct: EBI-25917615; Score: 0.56
DE  Interaction: Q9Y3C5; IntAct: EBI-25918856; Score: 0.56
DE  Interaction: Q8N2W9; IntAct: EBI-25922910; Score: 0.56
DE  Interaction: Q8WXH2; IntAct: EBI-25927801; Score: 0.56
DE  Interaction: P42858; IntAct: EBI-25944050; Score: 0.56
DE  Interaction: Q15326; IntAct: EBI-30825002; Score: 0.44
DE  Interaction: Q93009; IntAct: EBI-30842269; Score: 0.44
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0005741;
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0008195;
GO  GO:0003713;
GO  GO:0031100;
GO  GO:0044255;
GO  GO:0032869;
GO  GO:0009062;
GO  GO:0007077;
GO  GO:0031642;
GO  GO:1903741;
GO  GO:0006654;
GO  GO:0046473;
GO  GO:0120162;
GO  GO:0045740;
GO  GO:0045944;
GO  GO:0019432;
GO  GO:0006642;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MNYVGQLAGQVFVTVKELYKGLNPATLSGCIDIIVIRQPNGNLQCSPFHVRFGKMGVLRSREKVVDIEINGESVDLHMKL
SQ  GDNGEAFFVQETDNDQEVIPMHLATSPILSEGASRMECQLKRGSVDRMRGLDPSTPAQVIAPSETPSSSSVVKKRRKRRR
SQ  KSQLDSLKRDDNMNTSEDEDMFPIEMSSDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTP
SQ  SPSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSRKICDKSHFQAIHSESSDTFSD
SQ  QSPTLVGGALLDQNKPQTEMQFVNEEDLETLGAAAPLLPMIEELKPPSASVVQTANKTDSPSRKRDKRSRHLGADGVYLD
SQ  DLTDMDPEVAALYFPKNGDPSGLAKHASDNGARSANQSPQSVGSSGVDSGVESTSDGLRDLPSIAISLCGGLSDHREITK
SQ  DAFLEQAVSYQQFVDNPAIIDDPNLVVKIGSKYYNWTTAAPLLLAMQAFQKPLPKATVESIMRDKMPKKGGRWWFSWRGR
SQ  NTTIKEESKPEQCLAGKAHSTGEQPPQLSLATRVKHESSSSDEERAAAKPSNAGHLPLLPNVSYKKTLRLTSEQLKSLKL
SQ  KNGPNDVVFSVTTQYQGTCRCEGTIYLWNWDDKVIISDIDGTITRSDTLGHILPTLGKDWTHQGIAKLYHKVSQNGYKFL
SQ  YCSARAIGMADMTRGYLHWVNERGTVLPQGPLLLSPSSLFSALHREVIEKKPEKFKVQCLTDIKNLFFPNTEPFYAAFGN
SQ  RPADVYSYKQVGVSLNRIFTVNPKGELVQEHAKTNISSYVRLCEVVDHVFPLLKRSHSSDFPCSDTFSNFTFWREPLPPF
SQ  ENQDIHSASA
//