ID  Q14764;
PN  Major vault protein;
GN  MVP;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0185;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:15133037, ECO:0000269|PubMed:16441665}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:16441665}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16441665}. Note=5% found in the nuclear pore complex (PubMed:15133037). Translocates from the nucleus to the cytoplasm upon EGF treatment (PubMed:16441665).
DR  UNIPROT: Q14764;
DR  UNIPROT: Q96BG4;
DR  UNIPROT: Q9BPW6;
DR  UNIPROT: Q9BQT1;
DR  UNIPROT: Q9UBD1;
DR  PDB: 1Y7X;
DR  Pfam: PF11978;
DR  Pfam: PF01505;
DR  Pfam: PF17794;
DR  Pfam: PF17795;
DR  Pfam: PF17796;
DR  PROSITE: PS51224;
DR  OMIM: 605088;
DR  DisGeNET: 9961;
DE  Function: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. {ECO:0000269|PubMed:15133037, ECO:0000269|PubMed:16418217, ECO:0000269|PubMed:16441665}.
DE  Reference Proteome: Yes;
DE  Interaction: O15162; IntAct: EBI-3933015; Score: 0.44
DE  Interaction: O95271; IntAct: EBI-30837957; Score: 0.44
DE  Interaction: P21980; IntAct: EBI-11072363; Score: 0.35
DE  Interaction: Q06787; IntAct: EBI-26509623; Score: 0.37
DE  Interaction: Q07065; IntAct: EBI-3936356; Score: 0.37
DE  Interaction: P63104; IntAct: EBI-7198482; Score: 0.40
DE  Interaction: Q81TT4; IntAct: EBI-2816262; Score: 0.00
DE  Interaction: A0A6L7HH45; IntAct: EBI-2816269; Score: 0.00
DE  Interaction: Q81ME0; IntAct: EBI-2829464; Score: 0.00
DE  Interaction: A0A6L8PQC3; IntAct: EBI-2829450; Score: 0.00
DE  Interaction: A0A5P8YK76; IntAct: EBI-2863891; Score: 0.00
DE  Interaction: Q13573; IntAct: EBI-7950968; Score: 0.35
DE  Interaction: Q99459; IntAct: EBI-7954144; Score: 0.35
DE  Interaction: P34913; IntAct: EBI-3929246; Score: 0.37
DE  Interaction: P00738; IntAct: EBI-3930906; Score: 0.37
DE  Interaction: P52292; IntAct: EBI-3931479; Score: 0.37
DE  Interaction: P00156; IntAct: EBI-3932277; Score: 0.37
DE  Interaction: Q14161; IntAct: EBI-3934710; Score: 0.37
DE  Interaction: Q14764; IntAct: EBI-3934720; Score: 0.80
DE  Interaction: Q13423; IntAct: EBI-3938084; Score: 0.37
DE  Interaction: Q9NUX5; IntAct: EBI-3938387; Score: 0.37
DE  Interaction: Q9WMX2; IntAct: EBI-9079726; Score: 0.37
DE  Interaction: Q8NHY2; IntAct: EBI-9698226; Score: 0.35
DE  Interaction: Q6FHY5; IntAct: EBI-21250233; Score: 0.37
DE  Interaction: Q9QWF0; IntAct: EBI-11015136; Score: 0.35
DE  Interaction: Q9D6T1; IntAct: EBI-11015451; Score: 0.35
DE  Interaction: Q6IRU7; IntAct: EBI-11021803; Score: 0.35
DE  Interaction: P51692; IntAct: EBI-11024794; Score: 0.35
DE  Interaction: P60710; IntAct: EBI-11045267; Score: 0.35
DE  Interaction: Q9D8B3; IntAct: EBI-11052854; Score: 0.35
DE  Interaction: Q5SRY7; IntAct: EBI-11073514; Score: 0.35
DE  Interaction: Q3TRR0; IntAct: EBI-11074327; Score: 0.35
DE  Interaction: Q9NYZ3; IntAct: EBI-11081743; Score: 0.35
DE  Interaction: Q00610; IntAct: EBI-11082478; Score: 0.35
DE  Interaction: Q06180; IntAct: EBI-11091446; Score: 0.35
DE  Interaction: Q08380; IntAct: EBI-11108487; Score: 0.35
DE  Interaction: Q07797; IntAct: EBI-11108624; Score: 0.35
DE  Interaction: P18031; IntAct: EBI-11122129; Score: 0.35
DE  Interaction: H9XIJ5; IntAct: EBI-11514306; Score: 0.37
DE  Interaction: B4URF7; IntAct: EBI-11515262; Score: 0.37
DE  Interaction: Q16656; IntAct: EBI-24734362; Score: 0.56
DE  Interaction: Q86UW9; IntAct: EBI-24736031; Score: 0.56
DE  Interaction: Q8WUN7; IntAct: EBI-23853018; Score: 0.56
DE  Interaction: Q9H0E2; IntAct: EBI-23930246; Score: 0.56
DE  Interaction: Q96HA8; IntAct: EBI-24587066; Score: 0.56
DE  Interaction: Q53EP0; IntAct: EBI-25274658; Score: 0.56
DE  Interaction: P03431; IntAct: EBI-12579142; Score: 0.35
DE  Interaction: Q1K9H5; IntAct: EBI-12588645; Score: 0.35
DE  Interaction: Q6IQ23; IntAct: EBI-16398399; Score: 0.35
DE  Interaction: Q9UMR2; IntAct: EBI-21616596; Score: 0.35
DE  Interaction: Q9UKK3; IntAct: EBI-21846379; Score: 0.35
DE  Interaction: Q9P2K3; IntAct: EBI-21846379; Score: 0.35
DE  Interaction: Q9HD26; IntAct: EBI-21846379; Score: 0.35
DE  Interaction: P11142; IntAct: EBI-21846379; Score: 0.35
DE  Interaction: P62136; IntAct: EBI-16370519; Score: 0.35
DE  Interaction: P61417; IntAct: EBI-20817194; Score: 0.37
DE  Interaction: A0A380PIB3; IntAct: EBI-20817905; Score: 0.37
DE  Interaction: Q14254; IntAct: EBI-20913686; Score: 0.40
DE  Interaction: Q16778; IntAct: EBI-20926138; Score: 0.40
DE  Interaction: Q93079; IntAct: EBI-20926130; Score: 0.40
DE  Interaction: P57053; IntAct: EBI-20926122; Score: 0.40
DE  Interaction: P58876; IntAct: EBI-20926146; Score: 0.40
DE  Interaction: Q5QNW6; IntAct: EBI-20936876; Score: 0.40
DE  Interaction: P14404; IntAct: EBI-21026252; Score: 0.35
DE  Interaction: P13569; IntAct: EBI-25416349; Score: 0.35
DE  Interaction: O60496; IntAct: EBI-25390132; Score: 0.35
DE  Interaction: P20339; IntAct: EBI-25391898; Score: 0.35
DE  Interaction: Q8NHP6; IntAct: EBI-25617558; Score: 0.35
DE  Interaction: P02452; IntAct: EBI-26366205; Score: 0.35
DE  Interaction: P51114; IntAct: EBI-26510810; Score: 0.37
DE  Interaction: P51116; IntAct: EBI-26511983; Score: 0.37
DE  Interaction: Q13363; IntAct: EBI-27045766; Score: 0.35
DE  Interaction: P35226; IntAct: EBI-27109494; Score: 0.35
DE  Interaction: Q99592; IntAct: EBI-27093179; Score: 0.35
DE  Interaction: P63010; IntAct: EBI-30816432; Score: 0.44
GO  GO:0005737;
GO  GO:0005856;
GO  GO:0005829;
GO  GO:0070062;
GO  GO:0005576;
GO  GO:1904813;
GO  GO:0016020;
GO  GO:0005643;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:1990904;
GO  GO:0034774;
GO  GO:0042802;
GO  GO:0019901;
GO  GO:0019903;
GO  GO:0038127;
GO  GO:0051028;
GO  GO:0042059;
GO  GO:0031953;
GO  GO:0061099;
GO  GO:0015031;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MATEEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRMVTVPPRHYCTVANPVSRDAQGLVLFDVTGQ
SQ  VRLRHADLEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTALHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIPRKEVEVV
SQ  EIIQATIIRQNQALRLRARKECWDRDGKERVTGEEWLVTTVGAYLPAVFEEVLDLVDAVILTEKTALHLRARRNFRDFRG
SQ  VSRRTGEEWLVTVQDTEAHVPDVHEEVLGVVPITTLGPHNYCVILDPVGPDGKNQLGQKRVVKGEKSFFLQPGEQLEQGI
SQ  QDVYVLSEQQGLLLRALQPLEEGEDEEKVSHQAGDHWLIRGPLEYVPSAKVEVVEERQAIPLDENEGIYVQDVKTGKVRA
SQ  VIGSTYMLTQDEVLWEKELPPGVEELLNKGQDPLADRGEKDTAKSLQPLAPRNKTRVVSYRVPHNAAVQVYDYREKRARV
SQ  VFGPELVSLGPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADHARLQLQLAYNWHFEVNDRKDPQETAK
SQ  LFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRTAVFGFETSEAKGPDGMALPRPRDQAVFPQNGLVVSSVDV
SQ  QSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTG
SQ  TAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTE
SQ  AIGPSTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSTPINLFNTAFGLLGMGPEGQPLGRRVASGPSPGEGISPQSAQAP
SQ  QAPGDNHVVPVLR
//