ID  Q15256;
PN  Receptor-type tyrosine-protein phosphatase R;
GN  PTPRR;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: [Isoform Alpha]: Cell membrane; Single-pass type I membrane protein. [Isoform Delta]: Cytoplasm, perinuclear region. Note=Locates to the perinuclear areas within the cytoplasm. [Isoform Gamma]: Cytoplasm, perinuclear region. Note=Locates to the perinuclear areas within the cytoplasm.
DR  UNIPROT: Q15256;
DR  UNIPROT: B2R5Z7;
DR  UNIPROT: B7Z3J1;
DR  UNIPROT: F5GXR7;
DR  UNIPROT: O00342;
DR  UNIPROT: Q92682;
DR  UNIPROT: Q9UE65;
DR  PDB: 2A8B;
DR  Pfam: PF00102;
DR  PROSITE: PS00383;
DR  PROSITE: PS50056;
DR  PROSITE: PS50055;
DR  OMIM: 602853;
DR  DisGeNET: 5801;
DE  Function: Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
DE  Interaction: P00533; IntAct: EBI-20980716; Score: 0.37
DE  Interaction: P02545; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: P04626; IntAct: EBI-20977323; Score: 0.51
DE  Interaction: P42704; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: Q15256; IntAct: EBI-7670318; Score: 0.31
DE  Interaction: P19022; IntAct: EBI-2265623; Score: 0.00
DE  Interaction: P09619; IntAct: EBI-2265708; Score: 0.00
DE  Interaction: Q16539; IntAct: EBI-16067405; Score: 0.65
DE  Interaction: P28482; IntAct: EBI-7157244; Score: 0.58
DE  Interaction: Q9H0R8; IntAct: EBI-24684656; Score: 0.56
DE  Interaction: P06213; IntAct: EBI-21132493; Score: 0.51
DE  Interaction: Q8IWU2; IntAct: EBI-20979781; Score: 0.37
DE  Interaction: Q6ZMQ8; IntAct: EBI-20980062; Score: 0.37
DE  Interaction: Q15303; IntAct: EBI-20980546; Score: 0.37
DE  Interaction: P21860; IntAct: EBI-20980866; Score: 0.37
DE  Interaction: Q02763; IntAct: EBI-20981106; Score: 0.37
DE  Interaction: Q01973; IntAct: EBI-20981500; Score: 0.37
DE  Interaction: P07949; IntAct: EBI-20981400; Score: 0.37
DE  Interaction: P34925; IntAct: EBI-20981440; Score: 0.37
DE  Interaction: Q01974; IntAct: EBI-20981640; Score: 0.37
DE  Interaction: P08069; IntAct: EBI-20981970; Score: 0.37
DE  Interaction: Q13308; IntAct: EBI-20982240; Score: 0.37
DE  Interaction: P29317; IntAct: EBI-20982664; Score: 0.37
DE  Interaction: Q62190; IntAct: EBI-21223151; Score: 0.37
DE  Interaction: P04629; IntAct: EBI-21224974; Score: 0.37
DE  Interaction: P21802; IntAct: EBI-21226905; Score: 0.37
DE  Interaction: P22455; IntAct: EBI-21227046; Score: 0.37
DE  Interaction: P35968; IntAct: EBI-21227083; Score: 0.37
DE  Interaction: P17987; IntAct: EBI-25383510; Score: 0.35
DE  Interaction: P19338; IntAct: EBI-25383510; Score: 0.35
DE  Interaction: P22087; IntAct: EBI-25383510; Score: 0.35
DE  Interaction: P40227; IntAct: EBI-25383510; Score: 0.35
DE  Interaction: P48643; IntAct: EBI-25383510; Score: 0.35
DE  Interaction: P49368; IntAct: EBI-25383510; Score: 0.35
DE  Interaction: P50990; IntAct: EBI-25383510; Score: 0.35
DE  Interaction: P50991; IntAct: EBI-25383510; Score: 0.35
DE  Interaction: P78371; IntAct: EBI-25383510; Score: 0.35
DE  Interaction: Q13610; IntAct: EBI-25383510; Score: 0.35
DE  Interaction: Q5VZ46; IntAct: EBI-25383510; Score: 0.35
DE  Interaction: Q6P5R6; IntAct: EBI-25383510; Score: 0.35
DE  Interaction: Q99832; IntAct: EBI-25383510; Score: 0.35
DE  Interaction: Q9BQ67; IntAct: EBI-25383510; Score: 0.35
DE  Interaction: Q9NSD9; IntAct: EBI-25383510; Score: 0.35
DE  Interaction: Q9NUL7; IntAct: EBI-25383510; Score: 0.35
DE  Interaction: Q9NVI7; IntAct: EBI-25383510; Score: 0.35
DE  Interaction: O60783; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: O75688; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: P07237; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: P10809; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: P14625; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: P23528; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: P31153; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: P42166; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: P56134; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: P63261; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: P82650; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: P82673; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: P82675; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: P82914; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: P82930; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: Q02978; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: Q15149; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: Q16875; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: Q7L014; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: Q8NCE2; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: Q92552; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: Q92665; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: Q96EY1; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: Q96EY7; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: Q9BU76; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: Q9GZT3; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: Q9H3K6; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: Q9NWB6; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: Q9NXV2; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: Q9ULV4; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: Q9Y291; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: Q9Y2Q9; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: Q9Y2R9; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: Q9Y399; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: Q9Y3D9; IntAct: EBI-25393868; Score: 0.35
DE  Interaction: Q96F44; IntAct: EBI-27115100; Score: 0.35
DE  Interaction: Q9UL42; IntAct: EBI-27115100; Score: 0.42
DE  Interaction: P27361; IntAct: EBI-27115100; Score: 0.35
DE  Interaction: P49366; IntAct: EBI-27115100; Score: 0.35
DE  Interaction: P54886; IntAct: EBI-27115100; Score: 0.35
DE  Interaction: Q9UNH7; IntAct: EBI-27116713; Score: 0.27
DE  Interaction: O75165; IntAct: EBI-27116713; Score: 0.27
DE  Interaction: Q92609; IntAct: EBI-27116713; Score: 0.27
DE  Interaction: Q12768; IntAct: EBI-27116713; Score: 0.27
GO  GO:0030054;
GO  GO:0005829;
GO  GO:0005615;
GO  GO:0016021;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0019901;
GO  GO:0004725;
GO  GO:0005001;
GO  GO:0038128;
GO  GO:0001701;
GO  GO:0010633;
GO  GO:0070373;
GO  GO:0035335;
GO  GO:0006470;
GO  GO:0007165;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MRRAVCFPALCLLLNLHAAGCFSGNNDHFLAINQKKSGKPVFIYKHSQDIEKSLDIAPQKIYRHSYHSSSEAQVSKRHQI
SQ  VNSAFPRPAYDPSLNLLAMDGQDLEVENLPIPAANVIVVTLQMDVNKLNITLLRIFRQGVAAALGLLPQQVHINRLIGKK
SQ  NSIELFVSPINRKTGISDALPSEEVLRSLNINVLHQSLSQFGITEVSPEKNVLQGQHEADKIWSKEGFYAVVIFLSIFVI
SQ  IVTCLMILYRLKERFQLSLRQDKEKNQEIHLSPITLQPALSEAKTVHSMVQPEQAPKVLNVVVDPQGRGAPEIKATTATS
SQ  VCPSPFKMKPIGLQERRGSNVSLTLDMSSLGNIEPFVSIPTPREKVAMEYLQSASRILTRSQLRDVVASSHLLQSEFMEI
SQ  PMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMV
SQ  WQEDSPVIVMITKLKEKNEKCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDS
SQ  AQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFV
SQ  HHALCLYESRLSAETVQ
//