ID  Q17RY0;
PN  Cytoplasmic polyadenylation element-binding protein 4;
GN  CPEB4;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000250|UniProtKB:Q7TN98}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q7TN98}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q7TN98}. Postsynaptic density {ECO:0000250|UniProtKB:Q7TN98}. Cell projection, axon {ECO:0000250|UniProtKB:Q7TN98}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q7TN98}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q7TN98}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q7TN98}.
DR  UNIPROT: Q17RY0;
DR  UNIPROT: B7ZLQ7;
DR  UNIPROT: Q7Z310;
DR  UNIPROT: Q8N405;
DR  UNIPROT: Q9C0J0;
DR  PDB: 2MKI;
DR  PDB: 2MKJ;
DR  PDB: 5DIF;
DR  Pfam: PF16366;
DR  Pfam: PF16367;
DR  PROSITE: PS50102;
DR  OMIM: 610607;
DR  DisGeNET: 80315;
DE  Function: Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE- regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity). {ECO:0000250|UniProtKB:Q7TN98, ECO:0000269|PubMed:22138752, ECO:0000269|PubMed:24990967, ECO:0000269|PubMed:26398195, ECO:0000269|PubMed:27857118}.
DE  Reference Proteome: Yes;
DE  Interaction: Q8D052; IntAct: EBI-2848200; Score: 0.00
DE  Interaction: P50616; IntAct: EBI-8596337; Score: 0.54
DE  Interaction: Q9H4B6; IntAct: EBI-8799416; Score: 0.27
DE  Interaction: Q9H6Z9; IntAct: EBI-12503146; Score: 0.35
DE  Interaction: Q61474; IntAct: EBI-11474493; Score: 0.40
DE  Interaction: Q17RY0; IntAct: EBI-11474906; Score: 0.40
DE  Interaction: Q9BZB8; IntAct: EBI-11474918; Score: 0.40
DE  Interaction: Q6ZNJ1; IntAct: EBI-16749633; Score: 0.35
DE  Interaction: P69479; IntAct: EBI-25568044; Score: 0.35
GO  GO:0070161;
GO  GO:0005737;
GO  GO:0030425;
GO  GO:0043197;
GO  GO:0005783;
GO  GO:0030426;
GO  GO:1990124;
GO  GO:0043005;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0014069;
GO  GO:0045202;
GO  GO:0046872;
GO  GO:0003730;
GO  GO:0000900;
GO  GO:0043022;
GO  GO:0003723;
GO  GO:0008135;
GO  GO:0071230;
GO  GO:0036294;
GO  GO:0042149;
GO  GO:0035235;
GO  GO:2000766;
GO  GO:0043524;
GO  GO:0002931;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MGDYGFGVLVQSNTGNKSAFPVRFHPHLQPPHHHQNATPSPAAFINNNTAANGSSAGSAWLFPAPATHNIQDEILGSEKA
SQ  KSQQQEQQDPLEKQQLSPSPGQEAGILPETEKAKSEENQGDNSSENGNGKEKIRIESPVLTGFDYQEATGLGTSTQPLTS
SQ  SASSLTGFSNWSAAIAPSSSTIINEDASFFHQGGVPAASANNGALLFQNFPHHVSPGFGGSFSPQIGPLSQHHPHHPHFQ
SQ  HHHSQHQQQRRSPASPHPPPFTHRNAAFNQLPHLANNLNKPPSPWSSYQSPSPTPSSSWSPGGGGYGGWGGSQGRDHRRG
SQ  LNGGITPLNSISPLKKNFASNHIQLQKYARPSSAFAPKSWMEDSLNRADNIFPFPDRPRTFDMHSLESSLIDIMRAENDT
SQ  IKGRLNYSYPGSDSSLLINARTYGRRRGQSSLFPMEDGFLDDGRGDQPLHSGLGSPHCFSHQNGERVERYSRKVFVGGLP
SQ  PDIDEDEITASFRRFGPLIVDWPHKAESKSYFPPKGYAFLLFQDESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRP
SQ  WNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAIS
SQ  ARFVQLQHGEIDKRVEVKPYVLDDQLCDECQGARCGGKFAPFFCANVTCLQYYCEYCWAAIHSRAGREFHKPLVKEGGDR
SQ  PRHISFRWN
//