ID  Q19253;
PN  Transducer of Cdc42-dependent actin assembly protein 1 homolog;
GN  toca;
OS  6239;
SL  Nucleus Position: SL-0198;
SL  Comments: Cell junction {ECO:0000269|PubMed:19798448, ECO:0000269|PubMed:23150597}. Apical cell membrane {ECO:0000269|PubMed:19798448, ECO:0000269|PubMed:25775511}; Peripheral membrane protein {ECO:0000269|PubMed:19798448, ECO:0000269|PubMed:25775511}; Cytoplasmic side {ECO:0000269|PubMed:19798448, ECO:0000269|PubMed:25775511}. Basolateral cell membrane {ECO:0000269|PubMed:19798448, ECO:0000269|PubMed:25775511}; Peripheral membrane protein {ECO:0000269|PubMed:19798448, ECO:0000269|PubMed:25775511}; Cytoplasmic side {ECO:0000269|PubMed:19798448, ECO:0000269|PubMed:25775511}. Cytoplasmic vesicle {ECO:0000269|PubMed:19798448}. Cytoplasm {ECO:0000269|PubMed:23150597, ECO:0000269|PubMed:25775511}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:23150597}. Recycling endosome {ECO:0000269|PubMed:25775511}. Note=Co-localizes with ajm-1 at cell junctions (PubMed:19798448). Co-localizes with toca-2, rme-1, cdc-42 and wve-1 on recycling endosomes (PubMed:25775511). {ECO:0000269|PubMed:19798448, ECO:0000269|PubMed:25775511}.
DR  UNIPROT: Q19253;
DR  UNIPROT: Q8MQ82;
DR  Pfam: PF00611;
DR  Pfam: PF00018;
DR  PROSITE: PS51741;
DR  PROSITE: PS51860;
DR  PROSITE: PS50002;
DE  Function: Plays a role in protein trafficking, actin organization and embryonic morphogenesis (PubMed:19798448). Potentially acts as cdc-42 effector (PubMed:25775511). May play a role in hypodermal P-cell nuclear positioning (PubMed:23150597). Together with toca-2, is required for protein trafficking regulating yolk protein clathrin- mediated endocytosis by oocytes during oogenesis and retrograde recycling and the sorting of recycling endosome cargo proteins such as mig-14 (PubMed:19798448, PubMed:25775511). Also, together with toca-2, controls the distribution of actin at cell junctions (PubMed:19798448, PubMed:26578656). {ECO:0000269|PubMed:19798448, ECO:0000269|PubMed:23150597, ECO:0000269|PubMed:25775511, ECO:0000269|PubMed:26578656}.
DE  Reference Proteome: Yes;
DE  Interaction: P39055; IntAct: EBI-6533636; Score: 0.37
DE  Interaction: A0A1C3NSL9; IntAct: EBI-6533681; Score: 0.37
DE  Interaction: O17578; IntAct: EBI-6533651; Score: 0.37
DE  Interaction: Q09442; IntAct: EBI-6533666; Score: 0.37
DE  Interaction: G5ED57; IntAct: EBI-6533743; Score: 0.37
DE  Interaction: Q9XZI6; IntAct: EBI-6533696; Score: 0.37
DE  Interaction: B7WN72; IntAct: EBI-6533711; Score: 0.37
DE  Interaction: Q93343; IntAct: EBI-6533728; Score: 0.37
DE  Interaction: Q20877; IntAct: EBI-6533788; Score: 0.37
DE  Interaction: Q19782; IntAct: EBI-6533758; Score: 0.37
DE  Interaction: Q20010; IntAct: EBI-6533773; Score: 0.37
DE  Interaction: G5EFY6; IntAct: EBI-6533833; Score: 0.37
DE  Interaction: Q94246; IntAct: EBI-6533803; Score: 0.37
DE  Interaction: O01900; IntAct: EBI-6533818; Score: 0.37
DE  Interaction: G5EF97; IntAct: EBI-6533880; Score: 0.37
DE  Interaction: Q9U304; IntAct: EBI-6533863; Score: 0.37
DE  Interaction: G5EC72; IntAct: EBI-6533848; Score: 0.37
DE  Interaction: A8WFL0; IntAct: EBI-6533925; Score: 0.37
DE  Interaction: A5PEX6; IntAct: EBI-6533895; Score: 0.37
DE  Interaction: Q4VNJ8; IntAct: EBI-6533910; Score: 0.37
DE  Interaction: Q23571; IntAct: EBI-6533942; Score: 0.37
DE  Interaction: O17577; IntAct: EBI-6542246; Score: 0.37
DE  Interaction: O61701; IntAct: EBI-6542293; Score: 0.37
DE  Interaction: Q95QQ9; IntAct: EBI-6542278; Score: 0.37
DE  Interaction: Q1XFY2; IntAct: EBI-6542308; Score: 0.37
DE  Interaction: G5ECJ4; IntAct: EBI-6542323; Score: 0.37
DE  Interaction: F5GUF0; IntAct: EBI-6542340; Score: 0.37
DE  Interaction: Q95QA6; IntAct: EBI-6542370; Score: 0.37
DE  Interaction: A8XQ35; IntAct: EBI-6542387; Score: 0.37
GO  GO:0016324;
GO  GO:0016323;
GO  GO:0005911;
GO  GO:0097708;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0055037;
GO  GO:0048613;
GO  GO:0006897;
GO  GO:1904703;
GO  GO:2000370;
GO  GO:1901046;
GO  GO:0032956;
GO  GO:0007165;
TP  Membrane Topology: Peripheral; Source: UniProt - Sequence Analysis;
SQ  MNDSCSWDQLWDQQGTLNEYTGKGIDLLERIMAYSKERASIELEYSSKLKALSKKTAMKMKSESELWNSVSYVKGFHDVI
SQ  AGIVPVATQHELIAENLKSAVIPFTTQKIAEYRVAKKQLESDNSNLGKQLRMVIDEMAKSHKEYVKCYKETEAAMLKYAK
SQ  AEKNMDISRLELEKTKNNYQQKCGMLEESKQTYAVMTTKANEEQSAHYDRKLPQLLDNYKKLHTNRILDTVEILSKCVEA
SQ  ESCVNQIIASCHNDMRRDIGLIDPSRDANLVVENMKSGHPVPQPFVFEDLGHPQDRSSFMGGGASGPAGSMDGMDATMKK
SQ  GGTLMSKNGKGVARKQSMHQKFFGGGTADKKTDSGDYGTLPPQQRARKIAGKISDLEKEKDRATQSREGVSKMQAAYREN
SQ  PKLGNPSDCDAQLAQYGHEIDALSNQIQKFKILLDDVNAQLGAGGLSATSVGGSDTPPSIRSVSSASSGVTSRVNTINDA
SQ  HRTNGGVGGGRRESFSGSNGGSDTDPTINGNGHGRDELYEECSNPNPVLGEAIAQFAFDGAQDGTIRMEANEKLWLIEKD
SQ  EGDGWTRVRKENNSADGFVPSSYLKVTWFGKV
//