ID  Q21443;
PN  Lamin-1;
GN  lmn;
OS  6239;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus envelope {ECO:0000269|PubMed:16950114}. Nucleus inner membrane {ECO:0000269|PubMed:10982402, ECO:0000269|PubMed:11071918, ECO:0000269|PubMed:11907270, ECO:0000269|PubMed:12490171, ECO:0000269|PubMed:25057012}; Lipid-anchor {ECO:0000269|PubMed:10982402, ECO:0000269|PubMed:11071918, ECO:0000269|PubMed:12490171}; Nucleoplasmic side {ECO:0000269|PubMed:10982402, ECO:0000269|PubMed:11071918, ECO:0000269|PubMed:12490171}. Note=Remains in the nuclear envelope until late anaphase in early embryos. Depends on mel-28 for nuclear envelope localization after mitosis. {ECO:0000269|PubMed:10982402, ECO:0000269|PubMed:16950114}.
DR  UNIPROT: Q21443;
DR  UNIPROT: O62127;
DR  Pfam: PF00038;
DR  Pfam: PF00932;
DR  PROSITE: PS51842;
DR  PROSITE: PS51841;
DE  Function: Major component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:11071918, PubMed:25057012). Provides a framework for the nuclear envelope and probably also interacts with chromatin (PubMed:11071918, PubMed:25057012). Essential to maintain the shape and integrity of the nucleus, and for DNA replication (PubMed:11071918). Involved in spatial organization of nuclear pore complexes (PubMed:11071918). It is not a target for ced-3 during apoptosis, suggesting that lamin cleavage is not essential for apoptosis in C.elegans (PubMed:12064941). {ECO:0000269|PubMed:11071918, ECO:0000269|PubMed:12064941, ECO:0000269|PubMed:25057012}.
DE  Reference Proteome: Yes;
DE  Interaction: G5EEH9; IntAct: EBI-6455606; Score: 0.37
DE  Interaction: Q09601; IntAct: EBI-6460126; Score: 0.37
DE  Interaction: Q18508; IntAct: EBI-6459403; Score: 0.37
DE  Interaction: Q20924; IntAct: EBI-15599068; Score: 0.44
DE  Interaction: O44452; IntAct: EBI-333329; Score: 0.00
DE  Interaction: Q19633; IntAct: EBI-336260; Score: 0.00
DE  Interaction: Q19969; IntAct: EBI-336722; Score: 0.00
DE  Interaction: P91505; IntAct: EBI-342362; Score: 0.00
DE  Interaction: Q9XXH8; IntAct: EBI-343838; Score: 0.00
DE  Interaction: Q7JLR4; IntAct: EBI-2415544; Score: 0.49
DE  Interaction: Q9XTB5; IntAct: EBI-2535415; Score: 0.53
DE  Interaction: G5EDM4; IntAct: EBI-2913499; Score: 0.00
DE  Interaction: Q09284; IntAct: EBI-2915636; Score: 0.00
DE  Interaction: G5ECZ8; IntAct: EBI-2915821; Score: 0.00
DE  Interaction: C1P635; IntAct: EBI-2917320; Score: 0.00
DE  Interaction: O44548; IntAct: EBI-6455593; Score: 0.37
DE  Interaction: G5ECR7; IntAct: EBI-6459638; Score: 0.37
DE  Interaction: P34402; IntAct: EBI-6459648; Score: 0.37
DE  Interaction: Q19749; IntAct: EBI-6459668; Score: 0.37
DE  Interaction: Q9U3C1; IntAct: EBI-6459698; Score: 0.37
DE  Interaction: Q21295; IntAct: EBI-6459688; Score: 0.37
DE  Interaction: O01585; IntAct: EBI-6459708; Score: 0.37
DE  Interaction: P30642; IntAct: EBI-6459718; Score: 0.37
DE  Interaction: P91457; IntAct: EBI-6459728; Score: 0.37
DE  Interaction: Q86S68; IntAct: EBI-6459738; Score: 0.37
DE  Interaction: Q95XY1; IntAct: EBI-6459748; Score: 0.37
DE  Interaction: Q65XX1; IntAct: EBI-6459758; Score: 0.37
DE  Interaction: G5ECG0; IntAct: EBI-6459768; Score: 0.37
DE  Interaction: Q95QC4; IntAct: EBI-6459778; Score: 0.37
DE  Interaction: O02217; IntAct: EBI-6460096; Score: 0.37
DE  Interaction: Q8WQC0; IntAct: EBI-6460116; Score: 0.37
DE  Interaction: P39745; IntAct: EBI-6460106; Score: 0.37
DE  Interaction: Q95Y84; IntAct: EBI-6460136; Score: 0.37
DE  Interaction: P12114; IntAct: EBI-6460546; Score: 0.37
DE  Interaction: Q8MPS6; IntAct: EBI-6460556; Score: 0.37
DE  Interaction: Q23593; IntAct: EBI-6460571; Score: 0.37
DE  Interaction: Q09583; IntAct: EBI-6460581; Score: 0.37
DE  Interaction: Q17391; IntAct: EBI-6461424; Score: 0.37
DE  Interaction: Q21443; IntAct: EBI-6461509; Score: 0.64
DE  Interaction: O01527; IntAct: EBI-6748850; Score: 0.00
DE  Interaction: Q9GYG1; IntAct: EBI-6748863; Score: 0.00
DE  Interaction: O62090; IntAct: EBI-11466936; Score: 0.37
DE  Interaction: P34288; IntAct: EBI-11470392; Score: 0.37
DE  Interaction: Q95ZY7; IntAct: EBI-11471304; Score: 0.37
DE  Interaction: Q965F9; IntAct: EBI-11471316; Score: 0.37
GO  GO:0005638;
GO  GO:0005635;
GO  GO:0005637;
GO  GO:0005652;
GO  GO:0034399;
GO  GO:0042393;
GO  GO:0042802;
GO  GO:0005200;
GO  GO:0005198;
GO  GO:0008340;
GO  GO:0009792;
GO  GO:0007281;
GO  GO:0031507;
GO  GO:0006998;
GO  GO:0007097;
GO  GO:0030473;
GO  GO:0051664;
GO  GO:0006997;
GO  GO:0008284;
GO  GO:0008104;
GO  GO:0090435;
GO  GO:0051983;
GO  GO:0007346;
TP  Membrane Topology: Lipid-Anchored; Source: UniProt - By Similarity {ECO:0000250};
SQ  MSSRKGTRSSRIVTLERSANSSLSNNGGGDDSFGSTLLETSRLQEKDHLTSLNSRLATYIDKVRQLEQENNRLQVQIRDI
SQ  EVVEKKEKSNLADRFEAEKARLRRALDSAQDELAKYRIEYDAAKVEVKKLKPQVEKLERELAGAEEQALHAQSIADQSQA
SQ  KQKTLQARNDKLVVENDDLKKQNITLRDTVEGLKKAVEDETLLRTAANNKIKALEEDLAFALQQHKGELEEVRHKRQVDM
SQ  TTYAKQINDEYQSKLQDQIEEMRAQFKNNLHQNKTAFEDAYKNKLNAARERQEEAVSEAIHLRARVRDLETSSSGNASLI
SQ  ERLRSELDTLKRSFQEKLDDKDARIAELNQEIERMMSEFHDLLDVKIQLDAELKTYQALLEGEEERLNLTQEAPQNTSVH
SQ  HVSFSSGGASAQRGVKRRRVVDVNGEDQDIDYLNRRSKLNKETVGPVGIDEVDEEGKWVRVANNSEEEQSIGGYKLVVKA
SQ  GNKEASFQFSSRMKLAPHASATVWSADAGAVHHPPEVYVMKKQQWPIGDNPSARLEDSEGDTVSSITVEFSESSDPSDPA
SQ  DRCSIM
//