ID  Q23064;
PN  Nuclear migration protein unc-83;
GN  unc;
OS  6239;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0183;
SL  Comments: Nucleus membrane {ECO:0000269|PubMed:11748140, ECO:0000269|PubMed:19605495, ECO:0000269|PubMed:20005871, ECO:0000269|PubMed:27697906, ECO:0000305|PubMed:21411627}; Single-pass type IV membrane protein {ECO:0000305}. Nucleus outer membrane {ECO:0000269|PubMed:16481402}; Single-pass type IV membrane protein {ECO:0000305}. Note=The transmembrane domain associates with the nuclear envelope (PubMed:11748140). Co-localizes with unc-84 and lmn-1 at the nuclear envelope (PubMed:11748140). {ECO:0000269|PubMed:11748140}.
DR  UNIPROT: Q23064;
DR  UNIPROT: Q95WB6;
DE  Function: Cargo-specific adapter that is involved in nuclear migration during development and thereafter (PubMed:11748140, PubMed:19605495, PubMed:20005871, PubMed:20921138, PubMed:27697906). Component of the unc-83-unc-84 LINC (LInker of Nucleoskeleton and Cytoskeleton) complex where it interacts with unc-84 to form a bridge connecting the nuclear envelope to the cytoskeleton which allows for nuclear transport along microtubules (PubMed:11748140, PubMed:16481402, PubMed:25023515). Within the complex, connects the nuclear envelope to the microtubule cytoskeleton through the kinesin-1 light chain protein klc-2 (most likely within the Kinesin 1 motor complex) to regulate nuclear migrations (PubMed:19605495, PubMed:20921138). Moreover, within the complex, also recruits the large microtubule-associated bicd-1-dlc-1- egal-1 and lis-1-nud-2 complexes to the nuclear envelope to regulate both the bidirectional migration of nuclei and the extent of nuclear migrations (PubMed:20005871). Not required for centrosome attachment to the nucleus (PubMed:11748140). {ECO:0000269|PubMed:11748140, ECO:0000269|PubMed:16481402, ECO:0000269|PubMed:19605495, ECO:0000269|PubMed:20005871, ECO:0000269|PubMed:20921138, ECO:0000269|PubMed:25023515, ECO:0000269|PubMed:27697906}.
DE  Reference Proteome: Yes;
DE  Interaction: O45717; IntAct: EBI-2905337; Score: 0.60
DE  Interaction: P46822; IntAct: EBI-2904924; Score: 0.00
DE  Interaction: Q20745; IntAct: EBI-3884847; Score: 0.37
DE  Interaction: Q22799; IntAct: EBI-2905315; Score: 0.53
DE  Interaction: V6CJ04; IntAct: EBI-2905267; Score: 0.51
DE  Interaction: Q95QA6; IntAct: EBI-2905042; Score: 0.00
DE  Interaction: P10567; IntAct: EBI-2905052; Score: 0.00
DE  Interaction: Q94420; IntAct: EBI-2905058; Score: 0.00
DE  Interaction: G5ECD7; IntAct: EBI-2905066; Score: 0.00
DE  Interaction: H2KZ24; IntAct: EBI-2905073; Score: 0.00
DE  Interaction: P34397; IntAct: EBI-2905144; Score: 0.00
DE  Interaction: O76640; IntAct: EBI-2905160; Score: 0.00
DE  Interaction: H2KYJ3; IntAct: EBI-2905178; Score: 0.00
DE  Interaction: P34420; IntAct: EBI-2905187; Score: 0.00
DE  Interaction: Q5FC73; IntAct: EBI-2905241; Score: 0.00
GO  GO:0016021;
GO  GO:0016020;
GO  GO:0005635;
GO  GO:0005640;
GO  GO:0045503;
GO  GO:0040011;
GO  GO:0007399;
GO  GO:0007097;
GO  GO:0030473;
GO  GO:0018991;
GO  GO:0009791;
GO  GO:0090435;
GO  GO:0030334;
GO  GO:0040025;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MDVMDSFSEVEMPNDISSEDHLLKVIESSAEEVDIFLENCSSLYNLILDSLHNLTSKTISCECLDEMTSTLEKSAKKILA
SQ  ERPEAENSVLLRLNTICCAMDQLRVQHNSRMMSGADSDTASSARSSTSSSTGEMRLWLHEVERRLEINEKRIRVEPNLQL
SQ  LLSDQQALQLEIQHEGQLLVNRLNKQIKDDHDSDSSEEEKRKTCVDAIRKRWHTIYLNSLSLVCRIEELINHQQASEDSE
SQ  SDPDLVGPPIKRARIRTVGHLTASDTEESEADEEDRHSQTETVVTEDDNVLPFAENEYESIMDGRVTVDSCTSSSEDQMV
SQ  EQSTNKKWESVLQDVGYSSGENSIHEALNTCADHLVPETSDMRRKRIECSPVKAFYRTVQLEDMSDLEVTKAINHDVEEE
SQ  PNLSDSMYVNHDSTFLATQNLPEYDEVMALMDDDDLPMDMSMTESFNTKWREIHGQKKPLRRASRPSREQMNLIAKSSCD
SQ  ASSEDSSEGENQTNLEDDPEMMSVSFNSAQFDTSSPLKRQRSARGLKNASFLYDSLEMDGSFCSTRSEMLPPCKTRSLAR
SQ  RKLRVRRMPRSMSDGEQLGVVSSKPEGMMTPMIRVSPPSTPVRRLLRKLDEQIRNRDSDTAPEHSDAAQAYEWDEYNPPQ
SQ  KDDSISDRHIQTMTDISDQLMNIDDDFAEHFGTSSAIRLIEESKSHLRVVLKALEESDSNIPQLSNFELIARSNLRQVDE
SQ  ALKIQSGNQPSFLETSTLQDLRSEWANLYESIRSPFARIMHQVKKFAATLQEVSSMASLGDVDIRSKEDVAKTLDAVTAI
SQ  ERRLSSERQELRDLLASSSFRDVAKDLSCEFESVSEGYDDAVDKIGKMAHSLSQVKGEWDAWNSRQNDIRNAMVRIESHL
SQ  KEGQMDNKMIADEMELCQERMNSLETMCNYLTASLGSIQNESNSKNLPDFKAELSIYSNALARLKDRFNDMIRVPTPPTV
SQ  QFHPPEPLPSLARSMTTQTAEMESETENEPLTIAEAISSSRLIKFTFALSLLAALAAIFYYHVFGKPFGPHVTYVNGPPP
SQ  V
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