ID  Q23529;
PN  Zygote defective protein 12;
GN  zyg;
OS  6239;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus membrane {ECO:0000269|PubMed:14697201}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14697201}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:14697201}. Note=Localizes to the minus end of microtubules, proximal to the centrosome. Centrosomal localization requires sun-1 and microtubules.
DR  UNIPROT: Q23529;
DR  UNIPROT: Q2V4T6;
DR  UNIPROT: Q7JPD4;
DR  Pfam: PF19047;
DR  PROSITE: PS50021;
DE  Function: Cytoskeletal linker protein, which is essential for attachment of the centrosome to the nucleus (PubMed:14697201). Required for dynein localization to the nuclear envelope (PubMed:14697201). Forms a LINC (LInker of Nucleoskeleton and Cytoskeleton) complex together with unc-84, that may be involved in DNA damage repair (PubMed:27956467). {ECO:0000269|PubMed:14697201, ECO:0000269|PubMed:27956467}.
DE  Reference Proteome: Yes;
DE  Interaction: Q23529; IntAct: EBI-1570329; Score: 0.40
DE  Interaction: G5ECK7; IntAct: EBI-1570311; Score: 0.37
DE  Interaction: Q9U2Z1; IntAct: EBI-6457211; Score: 0.37
DE  Interaction: P91409; IntAct: EBI-6457201; Score: 0.37
DE  Interaction: G5ED30; IntAct: EBI-11465222; Score: 0.51
DE  Interaction: H2KYA1; IntAct: EBI-11469957; Score: 0.37
DE  Interaction: Q93198; IntAct: EBI-11471204; Score: 0.37
GO  GO:0005813;
GO  GO:0005737;
GO  GO:0016021;
GO  GO:0005874;
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0051959;
GO  GO:0008017;
GO  GO:0043621;
GO  GO:0051642;
GO  GO:0007059;
GO  GO:0031122;
GO  GO:0030705;
GO  GO:0009792;
GO  GO:0051647;
GO  GO:0035046;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MLDLTNKESESSDNGNSKYEDSIDGREVGTSKPFKEERSLEDLQADLADMAVWMEGLDATKLPLNDPQLLCNGRAFSEVL
SQ  HNVDKNFFTDGWLETMPENRTTNIMVFRSCTRKLWRKMFDYVNHINRTVVSSRWTDIHERIDGIYESDLPAMVNLGMAVV
SQ  TLAHIGKNAKRFVDYSKALTSTHKSMMSNVAKMVTTVIDEMPENPCFHEISELHGSQSELNSLSESSGKLNGNGSSERRS
SQ  NADQILVDAELEIERLRTETENQRKEIERLTKSFETAQHDMSSNSESGDISILEKQNEELRQKRRELEEKNLELDAAVDQ
SQ  FKGIVFELTNENDVLRRSDKERQRLQTVLDAAQSDLDEWKTVANQYQKEAELSKQQDKEIKELLSQNKALKSRLDHHVKS
SQ  ATLEDANKNGIAQLRTQVGGLTALNTELKASLDSKKRCVEQLEIQLIQHKEKVKELEDRKDELIEERNRLENQLIFKEAV
SQ  TPRSLHESMFEAGNLSFEPFSEKNTLPLEIENKRLTERIQELESLEPLKGELITLKSKNGVLEEEKLFATKQIEELQQQI
SQ  EDLQENLLKNQEHASGDVVGLKIQLEKAEVEAQQMREAKMRAETNQAQVDEILKKRTAELEVNATALQKAKAVIDELEYN
SQ  SRPVSEDSMTSVQAFKEMKEENEKLRQKVEKLEIELNTVTQGFEQENRLLTSASHQQVLNRSIDEVMSMRAHAGSEEPQT
SQ  LLDTQKMSGALPWRSLASETRRELPTAMASILVLGFLVFIAWMFININSALNAPPNA
//