ID  Q24246;
PN  Cytoplasmic dynein 1 intermediate chain;
GN  sw;
OS  7227;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9774695}. [Isoform 2c]: Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Aggregates in cytoplasm around lysosomes. [Isoform 2a]: Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Aggregates in cytoplasm around the nucleus. [Isoform 2b]: Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Aggregates in cytoplasm around the nucleus.
DR  UNIPROT: Q24246;
DR  UNIPROT: O96508;
DR  UNIPROT: O96510;
DR  UNIPROT: O96511;
DR  UNIPROT: O96512;
DR  UNIPROT: O96513;
DR  UNIPROT: O96514;
DR  UNIPROT: O96515;
DR  UNIPROT: O96516;
DR  UNIPROT: Q5U0Z1;
DR  UNIPROT: Q86BQ5;
DR  UNIPROT: Q9NG49;
DR  UNIPROT: Q9TZR7;
DR  UNIPROT: Q9TZR8;
DR  UNIPROT: Q9TZR9;
DR  UNIPROT: Q9TZS0;
DR  UNIPROT: Q9VR78;
DR  PDB: 2P2T;
DR  PDB: 3FM7;
DR  PDB: 3L9K;
DR  Pfam: PF11540;
DR  PROSITE: PS50082;
DR  PROSITE: PS50294;
DE  Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the help dynein bind to dynactin 150 kDa component (By similarity). {ECO:0000250, ECO:0000269|PubMed:11071907}.
DE  Reference Proteome: Yes;
DE  Interaction: Q8T0I9; IntAct: EBI-213466; Score: 0.00
DE  Interaction: Q4V5A7; IntAct: EBI-253285; Score: 0.00
DE  Interaction: Q9XZ56; IntAct: EBI-9919028; Score: 0.46
DE  Interaction: O61307; IntAct: EBI-9921261; Score: 0.35
DE  Interaction: P18431; IntAct: EBI-9925534; Score: 0.35
DE  Interaction: Q9VLS7; IntAct: EBI-9929131; Score: 0.35
DE  Interaction: Q24568; IntAct: EBI-9944837; Score: 0.35
GO  GO:0005868;
GO  GO:0005765;
GO  GO:0005874;
GO  GO:0043005;
GO  GO:0031965;
GO  GO:0032991;
GO  GO:0034452;
GO  GO:0045504;
GO  GO:0045503;
GO  GO:0060090;
GO  GO:0008088;
GO  GO:0007349;
GO  GO:0051642;
GO  GO:0001754;
GO  GO:0000226;
GO  GO:0007018;
GO  GO:0034501;
GO  GO:0007291;
GO  GO:0007051;
GO  GO:0010970;
TP  Membrane Topology: Peripheral; Source: UniProt - Sequence Analysis;
SQ  MDRKAELERKKAKLAALREEKDRRRREKEIKDMEEAAGRIGGGAGIDKDQRKDLDEMLSSLGVAPVSEVLSSLSSVNSMT
SQ  SDNSNTQTPDASLQATVNGQSGGKKQPLNLSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLSCHSSPLSGYMEDWW
SQ  RPRKAHATDYYDEYNLNPGLEWEDEFTDDEESSLQNLGNGFTSKLPPGYLTHGLPTVKDVAPAITPLEIKKETEVKKEVN
SQ  ELSEEQKQMIILSENFQRFVVRAGRVIERALSENVDIYTDYIGGGDSEEANDERSHARLSLNRVFYDERWSKNRCITSMD
SQ  WSTHFPELVVGSYHNNEESPNEPDGVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQK
SQ  RTPIQRTPLSAAAHTHPVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTLELQQRQSKAIAITSMAFPANEINS
SQ  LVMGSEDGYVYSASRHGLRSGVNEVYERHLGPITGISTHYNQLSPDFGHLFLTSSIDWTIKLWSLKDTKPLYSFEDNSDY
SQ  VMDVAWSPVHPALFAAVDGSGRLDLWNLNQDTEVPTASIVVAGAPALNRVSWTPSGLHVCIGDEAGKLYVYDVAENLAQP
SQ  SRDEWSRFNTHLSEIKMNQSDEV
//