ID  Q28EH9;
PN  Nuclear envelope integral membrane protein 1;
GN  nemp1;
OS  8364;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus inner membrane {ECO:0000250|UniProtKB:B9X187}; Multi-pass membrane protein {ECO:0000255}; Nucleoplasmic side {ECO:0000250|UniProtKB:B9X187}. Nucleus envelope {ECO:0000250|UniProtKB:B9X187}. Note=Localization in the nuclear membrane is essential for its function. Colocalizes with and lamins and banf1-a/b at the nuclear envelope. {ECO:0000250|UniProtKB:B9X187}.
DR  UNIPROT: Q28EH9;
DR  UNIPROT: Q5BJ84;
DR  Pfam: PF10225;
DE  Function: In concert with ran, required for proper eye development. May be involved in the expression of early eye marker genes. Contributes to nuclear envelope stiffness in germ cells (By similarity). Required for fertility (By similarity). {ECO:0000250|UniProtKB:B9X187, ECO:0000250|UniProtKB:O14524}.
DE  Reference Proteome: Yes;
GO  GO:0016021;
GO  GO:0005635;
GO  GO:0005637;
GO  GO:0001654;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MAGEVEGEGCRVSWGVLVALLLLPLPSLCSLTAGKQLQVIKLFEGRVVRYNESKNFCYQRTYEPKWSDVWTKIQIRVNST
SQ  KMIRVTQVENEEKLKEMETFNMFDFFSSFLKEKLNDSFIYVDLYNNKTCIKVHVSDTDTYYSVALSRGFDPRLFFVFLCG
SQ  LLLFFYGDTLSRSQIFYYSTGITVGMLASMLILVFMLSKLMPKKSPFVALLLGGWSVSIYVIQLVFKNLQAICTEYWQYL
SQ  LGYLGIVGFVSFAFCYKYGPLENERSINILNWTLQLIGLLLMYISVQIRHIAVTMVVIAFCTKQIEYPVRWIYILYRKIK
SQ  LKRGKPSPPRLLTEEEYRKQGDVETRKALEELRGYCSSPDFAAWKTVSRIQSPKRFADFVEGSSHLTPNEVSVHEHEYGF
SQ  GGSFLEDELFGEDSDVEEEMEIEPVLYQDLR
//