ID  Q2HJ92;
PN  Interferon-inducible double-stranded RNA-dependent protein kinase activator A;
GN  PRKRA;
OS  9913;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm {ECO:0000250}.
DR  UNIPROT: Q2HJ92;
DR  Pfam: PF00035;
DR  Pfam: PF16482;
DR  PROSITE: PS50137;
DE  Function: Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys- 386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005622;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0016442;
GO  GO:0070578;
GO  GO:0003725;
GO  GO:0008047;
GO  GO:0019899;
GO  GO:0070883;
GO  GO:0042803;
GO  GO:0035197;
GO  GO:0034599;
GO  GO:0042474;
GO  GO:0042473;
GO  GO:2001244;
GO  GO:0031054;
GO  GO:0006468;
GO  GO:0050821;
GO  GO:0070920;
GO  GO:0030422;
GO  GO:0048705;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSQSRHRAAAPPMEREDSGTFSLGKMITAKPGKTPIQVLHEYGMKTKNIPVYECERSDVQIHVPTFTFRVTVGDITCTGE
SQ  GTSKKLAKHRAAEAAINILKANASICFAVPDPLMPDPSKQPKNQLNPIGSLQELAIHHGWRLPEYTLSQEGGPAHKREYT
SQ  TICRLESFMETGKGASKKQAKRNAAEKFLAKFSNISPENHISLTNMVGHSLGCTWHSLRNSPGEKINLLKRSLLSIPNTD
SQ  YIQLLSEIAKEQGFNITYLDIEELSANGQYQCLAELSTSPITVCHGSGISCSSAQSDAAHNALQYLKIIAERK
//