ID  Q2PFW6;
PN  Gamma-synuclein;
GN  SNCG;
OS  9541;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle (By similarity). {ECO:0000250}.
DR  UNIPROT: Q2PFW6;
DR  Pfam: PF01387;
DE  Function: Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
GO  GO:0005815;
GO  GO:0048471;
GO  GO:0005819;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGTKTKENVVHSVTSVAEKTKEQANAVSEAVVSSVNTVAAK
SQ  TVEEAENIAVTSGVVRKEDLKPSAPQQEGEAAKEKEEVAEEAQSGGD
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