ID  Q2PKF4;
PN  Guanine nucleotide-binding protein G(q) subunit alpha;
GN  GNAQ;
OS  9823;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Cell membrane {ECO:0000250|UniProtKB:P50148}; Lipid-anchor {ECO:0000250|UniProtKB:P50148}. Golgi apparatus {ECO:0000250|UniProtKB:P50148}. Nucleus {ECO:0000250|UniProtKB:P21279}. Nucleus membrane {ECO:0000250|UniProtKB:P21279}. Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes. {ECO:0000250|UniProtKB:P21279}.
DR  UNIPROT: Q2PKF4;
DR  Pfam: PF00503;
DR  PROSITE: PS51882;
DE  Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Required for platelet activation. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity). Transduces FFAR4 signaling in response to long- chain fatty acids (LCFAs) (By similarity). Together with GNA11, required for heart development (By similarity). {ECO:0000250|UniProtKB:P21279, ECO:0000250|UniProtKB:P50148}.
DE  Reference Proteome: Yes;
GO  GO:0005794;
GO  GO:0005834;
GO  GO:0016020;
GO  GO:0031965;
GO  GO:0001750;
GO  GO:0045202;
GO  GO:0001664;
GO  GO:0031683;
GO  GO:0005525;
GO  GO:0005096;
GO  GO:0003924;
GO  GO:0046872;
GO  GO:0001508;
GO  GO:0007189;
GO  GO:0007188;
GO  GO:0009649;
GO  GO:0007213;
GO  GO:0007215;
GO  GO:0006469;
GO  GO:0007603;
GO  GO:0050821;
GO  GO:0060828;
GO  GO:0010543;
TP  Membrane Topology: Lipid-Anchored; Source: UniProt - By Similarity {ECO:0000250|UniProtKB:P21279};
SQ  MTLESIMACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKRGFTKLVY
SQ  QNIFTAMQAMIRAMDTLKIPYKYEHNKAHAQLVREVDVEKVSAFENPYVDAIKSLWNDPGIQECYDRRREYQLSDSTKYY
SQ  LNDLDRVADPAYLPTQQDVLRVRVPTTGIIEYPFDLQSVIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLV
SQ  ESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPQRDAQAAREFILKMFVDLNPDS
SQ  DKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
//