ID  Q3KP22;
PN  Membrane-anchored junction protein;
GN  MAJIN;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus inner membrane {ECO:0000250|UniProtKB:Q9D992}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9D992}. Chromosome, telomere {ECO:0000250|UniProtKB:Q9D992}. Note=In leptotene spermatocytes, localizes to telomeres that localize to the nucleus inner membrane. {ECO:0000250|UniProtKB:Q9D992}.
DR  UNIPROT: Q3KP22;
DR  UNIPROT: B3KS99;
DR  UNIPROT: E9PPE5;
DR  PDB: 6GNX;
DR  PDB: 6GNY;
DR  PDB: 6J08;
DR  Pfam: PF15077;
DR  OMIM: 617130;
DR  DisGeNET: 283129;
DE  Function: Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1- TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane. {ECO:0000250|UniProtKB:Q9D992}.
DE  Reference Proteome: Yes;
DE  Interaction: P27658; IntAct: EBI-24669930; Score: 0.56
DE  Interaction: Q9BSW7; IntAct: EBI-24682491; Score: 0.56
DE  Interaction: Q8NHR7; IntAct: EBI-23751777; Score: 0.56
DE  Interaction: Q9Y5W9; IntAct: EBI-24744300; Score: 0.56
DE  Interaction: Q86WT6; IntAct: EBI-24767358; Score: 0.56
DE  Interaction: O43741; IntAct: EBI-24773475; Score: 0.56
DE  Interaction: P53350; IntAct: EBI-21859936; Score: 0.35
DE  Interaction: P26998; IntAct: EBI-21859936; Score: 0.35
GO  GO:0000781;
GO  GO:0005639;
GO  GO:0003677;
GO  GO:0007129;
GO  GO:0070197;
GO  GO:0045141;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MSLKPFTYPFPETRFLHAGPNVYKFKIRYGKSIRGEEIENKEVITQELEVPVEKKAVGAVMRKRKHMDEPSSPSRPGLDR
SQ  AKIGTSSQGPSKKKPPVETRRNRERKTQQGLQETLASDITDVQKQDSEWGHSLPGRIVPPLQHNSPPPKERAATGFFGFL
SQ  SSLFPFRYFFRKSSHS
//