ID  Q3KTM2;
PN  Glycerophosphodiester phosphodiesterase domain-containing protein 5;
GN  GDPD5;
OS  9031;
SL  Nucleus Position: SL-0198;
SL  Comments: Endomembrane system {ECO:0000250|UniProtKB:Q640M6}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q640M6}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q640M6}.
DR  UNIPROT: Q3KTM2;
DR  Pfam: PF03009;
DR  PROSITE: PS51704;
DE  Function: Glycerophosphodiester phosphodiesterase that promotes cell cycle exit and drives spinal motor neuron differentiation (PubMed:16195461, PubMed:19766572, PubMed:23329048). Mediates the cleavage of glycosylphosphatidylinositol (GPI) anchor of target proteins: removes the GPI-anchor of RECK, leading to release RECK from the plasma membrane (PubMed:23329048). May contribute to the osmotic regulation of cellular glycerophosphocholine (By similarity). {ECO:0000250|UniProtKB:Q640M6, ECO:0000269|PubMed:16195461, ECO:0000269|PubMed:19766572, ECO:0000269|PubMed:23329048}.
DE  Reference Proteome: Yes;
DE  Interaction: P0CB50; IntAct: EBI-2464235; Score: 0.59
DE  Interaction: Q06830; IntAct: EBI-2464259; Score: 0.40
DE  Interaction: P35700; IntAct: EBI-2464725; Score: 0.40
GO  GO:0012505;
GO  GO:0030426;
GO  GO:0016021;
GO  GO:0016020;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0047389;
GO  GO:0008889;
GO  GO:0004435;
GO  GO:0006629;
GO  GO:0007399;
GO  GO:0045666;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MVKHQPLQYYEPQLCLSCLTGIYGCRWKRYQRSHDDTTKWERLWFLILTSSFFLTLVWFYFWWEVHNDYNEINWFLYNRM
SQ  GYWSDWSIPILVTTAAGFTYITVLLILALCHIAVGQQMNLHWLHKIGLMTTLITTVVTMSSIAQLWDDEWEMVFISLQAT
SQ  APFLHIGALAAVTALSWLIAGQFARMEKATSQMLMVTAYLAVVVALYLVPLTISSPCIMEKKALGPKPAIIGHRGAPMLA
SQ  PENTLMSFQKAVEQKIYGVQADVILSYDGVPFLMHDKTLRRTTNVEEVFPGRAYEHSSMFNWTDLEMLNAGEWFLRNDPF
SQ  WTAGSLSRSDYLEAANQSVCKLADMLEVIKDNTSLILNFQDLPPDHPYYTSYINITLKTILASGIQQQAVMWLPDTERQL
SQ  VRQIAPAFQQTSGLKLDAERLREKGIVKLNLRYTKVTNEDVRDYMAANLSVNLYTVNEPWLYSILWCTGVPSVTSDSSHV
SQ  LRKVPFPIWLMPPDEYRLIWITSDLISFIIIVGVFIFQNYHNDQWRLGSIRTYNPEQIMLSAAVRRSSRDVKIMKEKLIF
SQ  SEINNGVETTDELSLCSENGYANEMVTPTDHRDTRLRMN
//