ID  Q3SWU0;
PN  RISC-loading complex subunit TARBP2;
GN  Tarbp2;
OS  10116;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03034}. Cytoplasm, perinuclear region {ECO:0000255|HAMAP-Rule:MF_03034}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03034}.
DR  UNIPROT: Q3SWU0;
DR  Pfam: PF00035;
DR  PROSITE: PS50137;
DE  Function: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. {ECO:0000255|HAMAP- Rule:MF_03034}.
DE  Reference Proteome: Yes;
GO  GO:0005737;
GO  GO:0016604;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0016442;
GO  GO:0070578;
GO  GO:0003725;
GO  GO:0019899;
GO  GO:0042802;
GO  GO:0035198;
GO  GO:0070883;
GO  GO:0042803;
GO  GO:0047485;
GO  GO:0035197;
GO  GO:0098795;
GO  GO:0035196;
GO  GO:0035264;
GO  GO:0050689;
GO  GO:0061351;
GO  GO:0051149;
GO  GO:0045727;
GO  GO:0045070;
GO  GO:0031054;
GO  GO:1903798;
GO  GO:0070920;
GO  GO:0070921;
GO  GO:0046782;
GO  GO:0070922;
GO  GO:0007338;
GO  GO:0030422;
GO  GO:0043403;
GO  GO:0007286;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSEEDQGSGSTTGCGLPSIEQMLAANPGKTPISLLQEYGTRIGKTPVYDLLKAEGQAHQPNFTFRVTVGDTSCTGQGPSK
SQ  KAAKHKAAEVALKHLKGGSMLEPALEDSSSFSLLDSSVPEDTAVIAAEAAAPVPSALLTRSPPMEMQPPVSPQQSECNPV
SQ  GALQELVVQKGWRLPEYMVTQESGPAHRKEFTMTCRVERFIEIGSGTSKKLAKRNAAAKMLLRVHTVPLDARDGNEAEPD
SQ  DDHFSIGVSSRLDGLRNRGPGCTWDSLRNSVGEKILSLRNCSVGSLGSLGSACCSILSELSAEQAFHVSYLDIEELSLSG
SQ  LCQCLVELSTQPATVCYGSATTREAARGDAARRALQYLRIMAGSK
//