ID  Q3SYC2;
PN  2-acylglycerol O-acyltransferase 2;
GN  MOGAT2;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12621063, ECO:0000269|PubMed:27184406}; Multi-pass membrane protein {ECO:0000269|PubMed:12621063}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:27184406}.
DR  UNIPROT: Q3SYC2;
DR  UNIPROT: A8K7I3;
DR  UNIPROT: Q3SYC1;
DR  UNIPROT: Q6ZQZ2;
DR  UNIPROT: Q86UH6;
DR  UNIPROT: Q9H630;
DR  Pfam: PF03982;
DR  OMIM: 610270;
DR  DisGeNET: 80168;
DE  Function: Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). {ECO:0000269|PubMed:12621063, ECO:0000269|PubMed:27184406, ECO:0000269|PubMed:28420705}.
DE  Reference Proteome: Yes;
DE  Interaction: O60361; IntAct: EBI-21771873; Score: 0.40
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0016021;
GO  GO:1990578;
GO  GO:0003846;
GO  GO:0016407;
GO  GO:0006651;
GO  GO:0006071;
GO  GO:0050892;
GO  GO:0006629;
GO  GO:0006640;
GO  GO:0019432;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MVEFAPLFMPWERRLQTLAVLQFVFSFLALAEICTVGFIALLFTRFWLLTVLYAAWWYLDRDKPRQGGRHIQAIRCWTIW
SQ  KYMKDYFPISLVKTAELDPSRNYIAGFHPHGVLAVGAFANLCTESTGFSSIFPGIRPHLMMLTLWFRAPFFRDYIMSAGL
SQ  VTSEKESAAHILNRKGGGNLLGIIVGGAQEALDARPGSFTLLLRNRKGFVRLALTHGAPLVPIFSFGENDLFDQIPNSSG
SQ  SWLRYIQNRLQKIMGISLPLFHGRGVFQYSFGLIPYRRPITTVVGKPIEVQKTLHPSEEEVNQLHQRYIKELCNLFEAHK
SQ  LKFNIPADQHLEFC
//