ID  Q3U5C7;
PN  Prickle-like protein 1;
GN  Prickle1;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus membrane {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=A smaller amount is detected in the cytosol. {ECO:0000250}.
DR  UNIPROT: Q3U5C7;
DR  Pfam: PF00412;
DR  Pfam: PF06297;
DR  PROSITE: PS00478;
DR  PROSITE: PS50023;
DR  PROSITE: PS51303;
DE  Function: Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure (By similarity). Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
DE  Interaction: Q9QWI6; IntAct: EBI-27100778; Score: 0.35
DE  Interaction: Q8VIG1; IntAct: EBI-34578740; Score: 0.40
GO  GO:0005829;
GO  GO:0031965;
GO  GO:0005634;
GO  GO:0008270;
GO  GO:0035904;
GO  GO:0060976;
GO  GO:0090090;
GO  GO:2000691;
GO  GO:0045892;
GO  GO:0001843;
GO  GO:0032436;
GO  GO:0031398;
GO  GO:0006606;
TP  Membrane Topology: Lipid-Anchored; Source: UniProt - By Similarity {ECO:0000250};
SQ  MPLEMEPKMSKLVFGCQRSSTSDDDSGCALEEYAWVPPGLRPEQIQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHD
SQ  NEVRYCQSLSEEEKKELQVFSAQRKKEALGRGTIKLLSRAVMHAVCEQCGLQMNGGEVAVFASRAGPGVCWHPSCFVCFT
SQ  CNELLVDLIYFYQDGKIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQRYIMKDGRPFCC
SQ  GCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATEACFSCAQCKASLLGCPFLPKQGQIYCSKTCSLGEDIHASDSSDS
SQ  AFQSARSRDSRRSVRMGRSSRSADQCRQSLLLSPALNYKFPGLSGNADDTLSRKLDDVSLASRQGAGFANEEFWKARVEQ
SQ  EASEDPEEWAEHEDYMTQLLLKFGDKNLFQQQSSEVDPRASEHWIPDNMVTNKPEVKPNHQGLASKKYQSDMYWAQSQDG
SQ  LGDSAYGSHPGPASSRRLQELDLDHGAAGYTHDQSQWYEDSLECLSDLKPEQSIRDSMDSLALSNITGASVDGESKPRPS
SQ  LYSLQNFEEIEAEDCEKMSNMGTLNSSMLHRSAESLQSLNSGLCPEKILPEEKPAHLPVLRRSKSQSRPQQVKFSDDVID
SQ  NGSYDIEIRQPPMSERTRRRAYHFEERGSRPHHHRHRRSRKSRSDNALNLVTERKYSAKDRLRLYTPDNYEKFIQNKSAR
SQ  ELQAYMQNANLYSQYAHATSDYALQNPGMNRFLGLCGEDDDSWCSSSTSSSDSEEEGYFLGQPIPQPRPQRFTYYTDDLS
SQ  SPASALPTPQFTQRTTKSKKKKGHKGKNCIIS
//