ID  Q3U827;
PN  E3 ubiquitin-protein ligase RNF180;
GN  Rnf180;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Comments: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18363970}; Single-pass membrane protein {ECO:0000269|PubMed:18363970}. Nucleus envelope {ECO:0000269|PubMed:18363970}.
DR  UNIPROT: Q3U827;
DR  UNIPROT: Q3UW39;
DR  UNIPROT: Q80ZX1;
DR  UNIPROT: Q8CCR1;
DR  UNIPROT: Q9CXV6;
DR  Pfam: PF19332;
DR  PROSITE: PS00518;
DR  PROSITE: PS50089;
DE  Function: E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2. {ECO:0000269|PubMed:18363970}.
DE  Reference Proteome: Yes;
GO  GO:0016021;
GO  GO:0031227;
GO  GO:0005635;
GO  GO:0046872;
GO  GO:0031624;
GO  GO:0061630;
GO  GO:0030534;
GO  GO:0042415;
GO  GO:1901360;
GO  GO:0032436;
GO  GO:0031398;
GO  GO:0000209;
GO  GO:0050790;
GO  GO:0042428;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MKRSEESTSTQSPEEQTGTLHCWRCRKCIASSGCFMTPLETQVVEQDRHESVDAQNTCHLWHMNVDALPEWISCLLQKAQ
SQ  WTVGKLNCPFCGARLGGFNFVSTPKCSCGQLAAVHLCKSRTDHQAAQGGRLMRPALKHLPHPGVPSGCDKETLLTGGGSK
SQ  TRNHWLLSMARNSNGLGRLTEALCLEVRATYFEMKNEKLLFKASDPKCQPFVPQPDTGRCPSRASHRKSHSLDLNISEKL
SQ  ILLPTLYEIHRKPTAYPRLNETGPIDLSGLALPCSNSSCSFQSPPSFDPNMLLHRLSVAPHETQAQRGRECQCGLEASSV
SQ  YSDHANANSLPFLMDLPSAGRSVLEASDQEEHLSQLDFLRSASFPLGTINHRLNNRERSKLRTLRRQQRRERWLQKQGKY
SQ  SGVGLLDHMTVSNEMSTDEETEFPEEKDSYMCAVCLDVYFNPYMCYPCHHIFCEPCLRTLAKDNPASTPCPLCRTIISRV
SQ  FLQTELNNATKTFFTKEYLKIKQSFQKSSSAKWPLPSCRKGFHLFGGFHRRAAPVTRRQFPHGAHRMDYLHFEDDSRGWW
SQ  FDMDMVIIYIYSVNWVIGFVVFCFLCYFFFPF
//