ID  Q3UTJ2;
PN  Sorbin and SH3 domain-containing protein 2;
GN  Sorbs2;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Apical cell membrane {ECO:0000250|UniProtKB:O94875}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:O94875}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:O94875}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Found at the Z line sarcomeres, stress fibers, dense bodies and focal adhesion. In pancreatic acinar cells, localized preferentially to the apical membrane. Colocalized with vinculin and filamentous actin at focal adhesions and lamellipodia of pancreatic cells. {ECO:0000250, ECO:0000250|UniProtKB:O94875}.
DR  UNIPROT: Q3UTJ2;
DR  UNIPROT: Q3USC6;
DR  UNIPROT: Q80TS1;
DR  UNIPROT: Q8BJL6;
DR  UNIPROT: Q8BJU3;
DR  UNIPROT: Q8BLW9;
DR  UNIPROT: Q8BX47;
DR  UNIPROT: Q8CHU0;
DR  Pfam: PF00018;
DR  Pfam: PF14604;
DR  Pfam: PF02208;
DR  PROSITE: PS50002;
DR  PROSITE: PS50831;
DE  Function: Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 (By similarity). May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:O94875}.
DE  Reference Proteome: Yes;
DE  Interaction: Q7TPH6; IntAct: EBI-16731507; Score: 0.35
DE  Interaction: Q80YT7; IntAct: EBI-16732484; Score: 0.35
DE  Interaction: P83510; IntAct: EBI-16734044; Score: 0.35
DE  Interaction: Q62108; IntAct: EBI-16724752; Score: 0.35
DE  Interaction: Q9D415; IntAct: EBI-16725590; Score: 0.35
DE  Interaction: Q3UHD9; IntAct: EBI-16736255; Score: 0.35
DE  Interaction: P51637; IntAct: EBI-20565496; Score: 0.35
DE  Interaction: A2AKD7; IntAct: EBI-20566393; Score: 0.35
DE  Interaction: Q9QWI6; IntAct: EBI-27100778; Score: 0.35
DE  Interaction: P16056; IntAct: EBI-27118288; Score: 0.35
GO  GO:0016324;
GO  GO:0005856;
GO  GO:0030425;
GO  GO:0005925;
GO  GO:0030027;
GO  GO:0043025;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0014069;
GO  GO:0045202;
GO  GO:0030018;
GO  GO:0042802;
GO  GO:0019904;
GO  GO:0095500;
GO  GO:0007015;
GO  GO:0061049;
GO  GO:0007219;
GO  GO:1904393;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MNTDSGGCARKRAAMSVTLTSVKRVQSSPNLLAAGRESQSPDSAWRSYNDRNPETLNGDATYSSLAAKGFRSVRPNLQDK
SQ  RSPTQSQITINGNSGGAVSPVSYYQRPFSPSAYSLPASLNSSIIMQHGRSLDSAETYSQHAQSLDGTMGSSIPLYRSSEE
SQ  EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPGLYNSPYSAQSHPAAKTQTYRPLSKSHSD
SQ  NGTDAFKEVPSPVPPPHVPPRPRDQSSTLKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPVSIYQSSIDRSL
SQ  ERPSSSASMAGDFRKRRKSEPAVGPLRGLGDQSSSRTSPGRADLPGSSSTFTKSFISSSPSSPSRAQGGDDSKMCPPLCS
SQ  YSGLNGTPSGELECCNAYRQHLDVPGDSQRAITFKNGWQMARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKT
SQ  KSESMGSLLCEEDSKESCPMTWASPYIQEVCGNSRSRLKHRSAHNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRILQY
SQ  EKEQQHRGLLHGWSQSSTEEVPRDVVPTRISEFEKLIQKSKSMPNLGDEMLSPITLEPPQNGLCPKRRFSIESLLEEETQ
SQ  VRHPSQGQRSCKSNTLVPIHIEVTSDEQPRTHMEFSDSDQDGVVSDHSDYVHVEGSSFCSESDFDHFSFTSSESFYGSSH
SQ  HHHHHHHHHRHLISSCKGRCPASYTRFTTMLKHERAKHENMDRPRRQEMDPGLSKLAFLVSPVPFRRKKILTPQKQTEKA
SQ  KCKASVVEALDSALKDICDQIKAEKRRGSLPDNSILHRLISELLPQIPERNSSLHALKRSPMHQPFHPLPPDGASHCPLY
SQ  QNDCGRMPHSASFPDVDTTSNYHAQDYGSALSLQDHESPRSYSSTLTDLGRSASRERRGTPEKEKLPAKAVYDFKAQTSK
SQ  ELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPVQPGEIGEAIAKYNFNADTNVELSLR
SQ  KGDRIILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKRNAKGAEDYPDPPLPHSYSSDRIYTLSSNKPQRPGFSHENIQ
SQ  GGGEPFQALYNYTPRNEDELELRESDVVDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
//