ID  Q3ZCC9;
PN  Protein SEC13 homolog;
GN  SEC13;
OS  9913;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0185;
SL  Comments: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:P55735}; Peripheral membrane protein {ECO:0000250|UniProtKB:P55735}; Cytoplasmic side {ECO:0000250|UniProtKB:P55735}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P55735}; Peripheral membrane protein {ECO:0000250|UniProtKB:P55735}; Cytoplasmic side {ECO:0000250|UniProtKB:P55735}. Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:P55735}. Lysosome membrane {ECO:0000250|UniProtKB:P55735}. Note=In interphase, localizes at both sides of the NPC. {ECO:0000250|UniProtKB:P55735}.
DR  UNIPROT: Q3ZCC9;
DR  Pfam: PF00400;
DR  PROSITE: PS50082;
DR  PROSITE: PS50294;
DE  Function: Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles. Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum. {ECO:0000250|UniProtKB:P55735, ECO:0000250|UniProtKB:Q9D1M0}. As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. {ECO:0000250|UniProtKB:P55735}.
DE  Reference Proteome: Yes;
GO  GO:0030127;
GO  GO:0005789;
GO  GO:0061700;
GO  GO:0000776;
GO  GO:0005765;
GO  GO:0031080;
GO  GO:0005654;
GO  GO:0042802;
GO  GO:0005198;
GO  GO:0090114;
GO  GO:0090110;
GO  GO:0051028;
GO  GO:0032008;
GO  GO:1904263;
GO  GO:0032527;
GO  GO:0006606;
GO  GO:0072659;
TP  Membrane Topology: Peripheral; Source: UniProt - By Similarity {ECO:0000250|UniProtKB:P55735};
SQ  MVSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILVADLRGHEGPVWQVAWAHPMYGNILASCSYD
SQ  RKVIIWKEENGTWEKTHEHTGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGLGQWEVKKINNAHTIGCNAVSWAP
SQ  AVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRV
SQ  FVWTCDDASGNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGPVSTSVTEGQQN
SQ  DQ
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