ID  Q4FZW5;
PN  Nucleoporin SEH1-A;
GN  seh1l;
OS  8355;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0185;
SL  Comments: Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q96EE3}. Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:Q96EE3}. Lysosome membrane {ECO:0000250|UniProtKB:Q96EE3}.
DR  UNIPROT: Q4FZW5;
DR  PDB: 6LK8;
DR  PDB: 7VCI;
DR  PDB: 7VOP;
DR  Pfam: PF00400;
DR  PROSITE: PS50082;
DR  PROSITE: PS50294;
DE  Function: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore. {ECO:0000250|UniProtKB:Q96EE3}. As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway. {ECO:0000250|UniProtKB:Q96EE3}.
DE  Reference Proteome: Yes;
GO  GO:0005829;
GO  GO:0000776;
GO  GO:0005765;
GO  GO:0031080;
GO  GO:0005198;
GO  GO:0051315;
GO  GO:0051301;
GO  GO:0007080;
GO  GO:0051028;
GO  GO:0006999;
GO  GO:1904263;
GO  GO:0015031;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSENGNWHCTASWKTHSGSVWRVTWAHPEFGQVLASCSFD
SQ  RTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGVVRIYEAPDVMNLSQWSLQHEIS
SQ  CKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNIMGKVQIYEYNENTRKYAKAETLMSVSDPVHDIAFAPNLGRSFHILAV
SQ  ATKDVRIFTMKPLRKELSSSGGVTKFEIHTVAQFDNHNSQVWRVSWNITGTVLASSGDDGTVRLWKANYMDNWKCIGVLK
SQ  GDGNPVGNSYQGFFGSSVGSAGQSLQNSVNGTPSSGRKHS
//