ID  Q4KYY2;
PN  Cyclin-dependent kinase 5 activator 1, p25;
GN  CDK5R1;
OS  9997;
SL  Nucleus Position: SL-0198;
SL  Comments: [Cyclin-dependent kinase 5 activator 1, p35]: Cell membrane {ECO:0000250|UniProtKB:Q15078}; Lipid-anchor {ECO:0000250|UniProtKB:Q15078}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15078}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q15078}. Note=In the primary cortical neurons, p35 is present in the peripheries and nerve terminals. {ECO:0000250|UniProtKB:Q15078}. [Cyclin-dependent kinase 5 activator 1, p25]: Nucleus {ECO:0000250|UniProtKB:Q15078}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q15078}. Perikaryon {ECO:0000250|UniProtKB:Q15078}. Note=The conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, in nuclear and perinuclear regions. In the primary cortical neurons, p25 is primarily concentrated in the cell soma and is largely absent from neurites. {ECO:0000250|UniProtKB:Q15078}.
DR  UNIPROT: Q4KYY2;
DR  Pfam: PF03261;
DE  Function: p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000250|UniProtKB:Q15078}.
DE  Reference Proteome: No;
GO  GO:0043005;
GO  GO:0005634;
GO  GO:0043204;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0014069;
GO  GO:0016533;
GO  GO:0061575;
GO  GO:0048013;
GO  GO:0061001;
GO  GO:0048511;
TP  Membrane Topology: Lipid-Anchored; Source: UniProt - By Similarity {ECO:0000250|UniProtKB:Q15078};
SQ  MGTGLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSAKKKNSKKGQPNSSYQNNITH
SQ  LNNENLKKSLSCANLSTFAQPPPAQPPAPPANQLSGSQTGVSSSVKKAPHPSVTSAGTPKRVIVQASTSELLRCLGEFLC
SQ  RRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYVGNE
SQ  ISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQAFSDLKNESGQEDKKRLLLGLDR
//