ID Q4R4K0; PN Protein NDRG2; GN NDRG2; OS 9541; SL Nucleus Position: SL-0198; SL Comments: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Note=In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity). {ECO:0000250}. DR UNIPROT: Q4R4K0; DR Pfam: PF03096; DE Function: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation (By similarity). {ECO:0000250}. DE Reference Proteome: Yes; GO GO:0030426; GO GO:0048471; GO GO:0030154; GO GO:0007399; GO GO:0016055; TP Membrane Topology: Unknown; Source: UniProt - Sequence Analysis; SQ MAELQEVQITEEKPLLPGQTPEAAKIHSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFGDMQEIIQN SQ FVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCVLQYLNFSTVIGVGVGAGAYILSRYALNHPDTVEGLVLINIDPN SQ AKGWMDWAAHKLTGLTSSIPEMILGHLFSQEELSGNSELIQKYRNIITHAPNLDNIELYWNSYNNRRDLNFERGGDITLK SQ CPVMLVVGDQAPHEDAVVECNSKLDPTQTSSLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYMASSCMTRLSRSRTASLT SQ SAASIDGNRSRSRTLSQSSESGTLSSGPPGHTMEVSC //