ID  Q58A65;
PN  C-Jun-amino-terminal kinase-interacting protein 4;
GN  Spag9;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:12391307, ECO:0000269|PubMed:15767678, ECO:0000269|PubMed:19056739}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:12391307, ECO:0000269|PubMed:19056739}. Lysosome membrane {ECO:0000250|UniProtKB:O60271}. Note=Perinuclear distribution in response to stress signals such as UV radiation. {ECO:0000269|PubMed:12391307}.
DR  UNIPROT: Q58A65;
DR  UNIPROT: Q3UH77;
DR  UNIPROT: Q3UHF0;
DR  UNIPROT: Q58VQ4;
DR  UNIPROT: Q5NC70;
DR  UNIPROT: Q5NC78;
DR  UNIPROT: Q6A057;
DR  UNIPROT: Q6PAS3;
DR  UNIPROT: Q8CJC2;
DR  Pfam: PF16471;
DR  Pfam: PF09744;
DR  PROSITE: PS51776;
DR  PROSITE: PS51777;
DE  Function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12391307, PubMed:15767678). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (By similarity). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (PubMed:19056739). {ECO:0000250|UniProtKB:O60271, ECO:0000269|PubMed:12391307, ECO:0000269|PubMed:15767678, ECO:0000269|PubMed:19056739}.
DE  Reference Proteome: Yes;
DE  Interaction: O88447; IntAct: EBI-7681081; Score: 0.58
DE  Interaction: P62331; IntAct: EBI-7986227; Score: 0.60
DE  Interaction: Q5S007; IntAct: EBI-6530261; Score: 0.40
GO  GO:0034451;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005765;
GO  GO:0048471;
GO  GO:0042802;
GO  GO:0008432;
GO  GO:0019894;
GO  GO:0005078;
GO  GO:0030159;
GO  GO:0032418;
GO  GO:1903860;
GO  GO:0045665;
GO  GO:0001933;
GO  GO:0030335;
GO  GO:0043410;
GO  GO:0045666;
GO  GO:0042147;
GO  GO:0051146;
GO  GO:0016192;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRD
SQ  DNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALH
SQ  QRHTEMIHNYMEHLERTKLHQLSGSDQLEATAHSRIRKERPISLGIFPLPAGDGLLTPDTQKGGETPGSEQWKFQELSQP
SQ  RSHTSLKVSHSPEPPKAVEQEDELSDISQGGSKATTPASTANSDVSAIPPDTPSKEDNEGFVKGTDTSNKSEISKHIEVQ
SQ  VAQETRNVSTESGENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEG
SQ  ADLLGMGREVENLILENTQLLETKNALNVVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEDKNRELEEELRKARAEA
SQ  EDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLF
SQ  SSSSNATKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKED
SQ  GRVQAFGWSLPQKYKQVANGQGETKMKNLPVPVYLRPLDEKDASMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDIAGLD
SQ  TEGSKQRSASQSSLDKLDQELKEQQKEFKNQEELSSQVWICTSTHSTTKVIIIDAVQPGNILDSFTVCNSHVLCIASVPG
SQ  ARETDYPAGEELSESGQVDKASLCGSMTSNSSAEMDSLLGGITVVGCSTEGLTGAATSPSTNGASPVIEKPPEMETENSE
SQ  VDENIPTAEEATEATEGNAGSTEDTVDISQPGVYTEHVFTDPLGVQIPEDLSPVFQSSNDSDVYKDQISVLPNEQDLARE
SQ  EAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHL
SQ  LDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTY
SQ  QHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGTPGNRPGSVIRVYGDENSDK
SQ  VTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSGGADLTADKAGSSAQEPSSQTPLKSMLVISGGEGYID
SQ  FRMGDEGGESELLGEDLPLEPSVTKAERSHLIVWQVMCGNE
//