ID  Q5BJF2;
PN  Sigma intracellular receptor 2;
GN  TMEM97;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus membrane {ECO:0000269|PubMed:19583955}; Multi-pass membrane protein {ECO:0000255}. Rough endoplasmic reticulum membrane {ECO:0000269|PubMed:19583955}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at cell membrane and in lysosomes in sterol-depleted cells when expression of endogenous TMEM97 is stimulated. {ECO:0000269|PubMed:19583955}.
DR  UNIPROT: Q5BJF2;
DR  UNIPROT: B4DS02;
DR  UNIPROT: Q07823;
DR  PROSITE: PS51751;
DR  OMIM: 612912;
DR  DisGeNET: 27346;
DE  Function: Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cancer cells (PubMed:28559337). Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation (PubMed:23922215, PubMed:25620095). Under investigation for its potential diagnostic and therapeutic uses (PubMed:23922215, PubMed:25620095). May play a role as a regulator of cellular cholesterol homeostasis (PubMed:19583955). May function as sterol isomerase (PubMed:25566323). May alter the activity of some cytochrome P450 proteins (PubMed:22292588). {ECO:0000269|PubMed:19583955, ECO:0000269|PubMed:28559337, ECO:0000303|PubMed:22292588, ECO:0000303|PubMed:23922215, ECO:0000303|PubMed:25620095, ECO:0000305|PubMed:25566323}.
DE  Reference Proteome: Yes;
DE  Interaction: O14524; IntAct: EBI-24702243; Score: 0.56
DE  Interaction: Q15125; IntAct: EBI-24740501; Score: 0.56
DE  Interaction: Q9GZY8; IntAct: EBI-24506673; Score: 0.56
DE  Interaction: Q13323; IntAct: EBI-24613171; Score: 0.56
DE  Interaction: O60883; IntAct: EBI-24662803; Score: 0.56
DE  Interaction: A6NM10; IntAct: EBI-24668368; Score: 0.56
DE  Interaction: Q8TDT2; IntAct: EBI-24673216; Score: 0.56
DE  Interaction: Q8TAF8; IntAct: EBI-23694570; Score: 0.56
DE  Interaction: Q9Y320; IntAct: EBI-23716233; Score: 0.56
DE  Interaction: Q13336; IntAct: EBI-24687434; Score: 0.56
DE  Interaction: Q6IN84; IntAct: EBI-23725656; Score: 0.56
DE  Interaction: Q9Y375; IntAct: EBI-24692888; Score: 0.56
DE  Interaction: Q13520; IntAct: EBI-24707719; Score: 0.56
DE  Interaction: P43628; IntAct: EBI-24715119; Score: 0.56
DE  Interaction: Q96K19; IntAct: EBI-24716686; Score: 0.56
DE  Interaction: Q13113; IntAct: EBI-24720124; Score: 0.56
DE  Interaction: Q9NUH8; IntAct: EBI-24720080; Score: 0.56
DE  Interaction: O15552; IntAct: EBI-24721232; Score: 0.56
DE  Interaction: Q9NR31; IntAct: EBI-24722305; Score: 0.56
DE  Interaction: O95470; IntAct: EBI-23777879; Score: 0.56
DE  Interaction: Q7Z5P4; IntAct: EBI-23790301; Score: 0.56
DE  Interaction: P41181; IntAct: EBI-24750677; Score: 0.56
DE  Interaction: Q7Z7G2; IntAct: EBI-24754691; Score: 0.56
DE  Interaction: P19397; IntAct: EBI-24755339; Score: 0.56
DE  Interaction: Q9H400; IntAct: EBI-24767380; Score: 0.56
DE  Interaction: O75712; IntAct: EBI-24767724; Score: 0.56
DE  Interaction: P15941; IntAct: EBI-24768397; Score: 0.56
DE  Interaction: Q9Y680; IntAct: EBI-24770454; Score: 0.56
DE  Interaction: Q99675; IntAct: EBI-23863356; Score: 0.56
DE  Interaction: O95377; IntAct: EBI-24782498; Score: 0.56
DE  Interaction: Q9H2K0; IntAct: EBI-24797742; Score: 0.56
DE  Interaction: Q14802; IntAct: EBI-23909400; Score: 0.56
DE  Interaction: O75787; IntAct: EBI-25276925; Score: 0.56
DE  Interaction: P38484; IntAct: EBI-25288358; Score: 0.56
DE  Interaction: Q9H902; IntAct: EBI-25288571; Score: 0.56
DE  Interaction: Q96B21; IntAct: EBI-25288527; Score: 0.56
DE  Interaction: Q9BSE2; IntAct: EBI-24449108; Score: 0.56
DE  Interaction: Q8WWH4; IntAct: EBI-24547189; Score: 0.56
DE  Interaction: Q9BVX2; IntAct: EBI-24551340; Score: 0.56
DE  Interaction: P04233; IntAct: EBI-24558651; Score: 0.56
DE  Interaction: Q96AG4; IntAct: EBI-24560640; Score: 0.56
DE  Interaction: A2A2Y4; IntAct: EBI-24581809; Score: 0.56
DE  Interaction: Q9BXK5; IntAct: EBI-24604201; Score: 0.56
DE  Interaction: Q15849; IntAct: EBI-24636787; Score: 0.60
DE  Interaction: Q9BQ51; IntAct: EBI-24646794; Score: 0.56
DE  Interaction: O95471; IntAct: EBI-24650808; Score: 0.56
DE  Interaction: Q9Y282; IntAct: EBI-24653486; Score: 0.56
DE  Interaction: Q8TED1; IntAct: EBI-24654027; Score: 0.56
DE  Interaction: Q9H7M9; IntAct: EBI-24659004; Score: 0.56
DE  Interaction: Q5JX71; IntAct: EBI-24745243; Score: 0.56
DE  Interaction: Q3SXY8; IntAct: EBI-24747218; Score: 0.56
DE  Interaction: Q4KMG9; IntAct: EBI-24761990; Score: 0.56
DE  Interaction: O43278; IntAct: EBI-24774612; Score: 0.56
DE  Interaction: P60201; IntAct: EBI-24802605; Score: 0.56
DE  Interaction: Q8WWF3; IntAct: EBI-24805465; Score: 0.56
DE  Interaction: A8MZ59; IntAct: EBI-24807328; Score: 0.56
DE  Interaction: Q8N183; IntAct: EBI-24808896; Score: 0.56
DE  Interaction: Q9BQT9; IntAct: EBI-25265926; Score: 0.56
DE  Interaction: Q9UBD6; IntAct: EBI-25275092; Score: 0.56
DE  Interaction: Q9P296; IntAct: EBI-21519943; Score: 0.35
DE  Interaction: Q13477; IntAct: EBI-21555701; Score: 0.35
DE  Interaction: P32241; IntAct: EBI-21613594; Score: 0.35
DE  Interaction: Q16774; IntAct: EBI-21649631; Score: 0.35
DE  Interaction: O00186; IntAct: EBI-21649631; Score: 0.35
DE  Interaction: P01903; IntAct: EBI-21827013; Score: 0.35
DE  Interaction: Q9BX73; IntAct: EBI-21890043; Score: 0.35
DE  Interaction: P14404; IntAct: EBI-21028244; Score: 0.35
DE  Interaction: Q5S007; IntAct: EBI-21360986; Score: 0.35
DE  Interaction: P05067; IntAct: EBI-21132574; Score: 0.35
DE  Interaction: P0DOF2; IntAct: EBI-25603126; Score: 0.35
DE  Interaction: P0DTD3; IntAct: EBI-25491532; Score: 0.53
DE  Interaction: P60033; IntAct: EBI-25645944; Score: 0.35
DE  Interaction: H9EJ66; IntAct: EBI-25685143; Score: 0.35
DE  Interaction: P19739; IntAct: EBI-25685423; Score: 0.35
GO  GO:0005783;
GO  GO:0016021;
GO  GO:0005764;
GO  GO:0031965;
GO  GO:0005886;
GO  GO:0005791;
GO  GO:0030867;
GO  GO:0042632;
GO  GO:0001558;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MGAPATRRCVEWLLGLYFLSHIPITLFMDLQAVLPRELYPVEFRNLLKWYAKEFKDPLLQEPPAWFKSFLFCELVFQLPF
SQ  FPIATYAFLKGSCKWIRTPAIIYSVHTMTTLIPILSTFLFEDFSKASGFKGQRPETLHERLTLVSVYAPYLLIPFILLIF
SQ  MLRSPYYKYEEKRKKK
//