ID  Q5BJY9;
PN  Keratin, type I cytoskeletal 18;
GN  Krt18;
OS  10116;
SL  Nucleus Position: SL-0198;
SL  Comments: Nucleus matrix {ECO:0000269|PubMed:16128803, ECO:0000269|PubMed:16998620}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P05783}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P05783}. Cytoplasm {ECO:0000269|PubMed:16128803, ECO:0000269|PubMed:16998620}.
DR  UNIPROT: Q5BJY9;
DR  UNIPROT: Q63278;
DR  Pfam: PF00038;
DR  PROSITE: PS00226;
DR  PROSITE: PS51842;
DE  Function: When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection (By similarity). Involved in the uptake of thrombin- antithrombin complexes by hepatic cells. {ECO:0000250|UniProtKB:P05783, ECO:0000269|PubMed:9353322}.
DE  Reference Proteome: Yes;
DE  Interaction: P54645; IntAct: EBI-16399805; Score: 0.35
DE  Interaction: P80386; IntAct: EBI-16400563; Score: 0.35
GO  GO:0071944;
GO  GO:0034451;
GO  GO:0005737;
GO  GO:0005856;
GO  GO:0009897;
GO  GO:0005615;
GO  GO:0005882;
GO  GO:0045095;
GO  GO:0005815;
GO  GO:0016363;
GO  GO:0005730;
GO  GO:0005886;
GO  GO:0032991;
GO  GO:0097110;
GO  GO:0005198;
GO  GO:1902488;
GO  GO:0097191;
GO  GO:0043000;
GO  GO:0097284;
GO  GO:0070365;
GO  GO:0045104;
GO  GO:0072497;
GO  GO:0043066;
GO  GO:0009750;
GO  GO:0031667;
GO  GO:0033209;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSFTTRSTTFSTNYRSLGSVRTPSQRVRPASSAASVYAGAGGSGSRISVSRSVWGGSVGSAGLAGMGGVQTEKETMQDLN
SQ  DRLASYLDKVKNLETENRRLESKIREYLEKRGPQGVRDWGHYFKTIEDLRAQIFANSVDNARIVLQIDNARLAADDFRVK
SQ  YETELAMRQSVESDIHGLRKVVDDTNITRLQLETEIEALKEELLFMKKNHEEEVQGLEAQIASSGLTVEVDAPKSQDLSK
SQ  IMADIRAQYEQLAQKNREELDKYWSQQIEESTTVVTTKSAEIRDAETTLLELRRTLQTLEIDLDSMKNQNINLENNLGEV
SQ  EARYRVQMEQLNGVLLHLESELAQTRAEGQRQTQEYEALLNIKVKLEAEIATYRRLLEDGDDFSLNDALDSSNSMQTVQR
SQ  TTTRKVVDGKVVSETNDTRVLRH
//