ID  Q5E9B7;
PN  Chloride intracellular channel protein 1;
GN  CLIC1;
OS  9913;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus {ECO:0000250}. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). {ECO:0000250}.
DR  UNIPROT: Q5E9B7;
DR  Pfam: PF13409;
DR  PROSITE: PS50405;
DE  Function: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
GO  GO:0034707;
GO  GO:0005737;
GO  GO:0070062;
GO  GO:0016020;
GO  GO:0005739;
GO  GO:0031965;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0005254;
GO  GO:0005244;
GO  GO:0006821;
GO  GO:0045669;
GO  GO:0051726;
GO  GO:0034765;
GO  GO:0051881;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MAEEQPQVELFVKAGSDGAKIGNCPFSQRLFMVLWLKGVTFNVTTVDTKRRTETVQKLCPGGQLPFLLYGTEVHTDTNKI
SQ  EEFLEAVLCPPRYPKLAALNPESNTAGLDIFAKFSAYIKNSNPALNDNLEKGLLKALKVLDNYLTSPLPDEVDETSAEDE
SQ  GISQRKFLDGNELTLADCNLLPKLHIVQVVCKKYRGFSIPDVFRGVHRYLRNAYAREEFASTCPDDEEIELAYEQVAKAL
SQ  K
//