ID  Q5FW52;
PN  Muscular LMNA-interacting protein;
GN  Mlip;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Comments: Nucleus {ECO:0000269|PubMed:21498514, ECO:0000269|PubMed:22343712, ECO:0000269|PubMed:26436652}. Nucleus envelope {ECO:0000269|PubMed:21498514}. Nucleus, PML body {ECO:0000269|PubMed:21498514}. Cell membrane, sarcolemma {ECO:0000269|PubMed:26359501}; Peripheral membrane protein {ECO:0000269|PubMed:26359501}; Cytoplasmic side {ECO:0000269|PubMed:26359501}.
DR  UNIPROT: Q5FW52;
DR  UNIPROT: Q9D6X9;
DR  Pfam: PF15274;
DE  Function: Required for precocious cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays an important role in protection against cardiac hypertrophy (PubMed:26359501, PubMed:22343712, PubMed:26436652). Acts as a transcriptional cofactor, represses transactivator activity of ISL1 and MYOCD (PubMed:22343712). {ECO:0000269|PubMed:22343712, ECO:0000269|PubMed:26359501, ECO:0000269|PubMed:26436652}.
DE  Reference Proteome: Yes;
DE  Interaction: P02545; IntAct: EBI-3895559; Score: 0.44
DE  Interaction: P48678; IntAct: EBI-3895570; Score: 0.49
DE  Interaction: P29590; IntAct: EBI-3895585; Score: 0.32
DE  Interaction: Q9QWI6; IntAct: EBI-27100778; Score: 0.35
GO  GO:0005635;
GO  GO:0031981;
GO  GO:0005634;
GO  GO:0016605;
GO  GO:0042383;
GO  GO:0005521;
GO  GO:0003714;
GO  GO:0010614;
GO  GO:1903243;
GO  GO:0000122;
GO  GO:0006366;
TP  Membrane Topology: Peripheral; Source: UniProt - Experimental Evidence {ECO:0000269|PubMed:26359501};
SQ  MEFGKHEPGSSLKRNKNLEEGVTFEYSDHMTFSSESKQERVQRILDYPSEVSGRNSQQKEFNTKEPQGMQKGDLFKAEYV
SQ  FIVDSDGEDEATCRQGEQGPPGGPGNIATRPKSLAISSSLASDVVRPKVRGADLKTSSHPEIPHGIAPQQKHGLALDEPA
SQ  RTESNSKASVLDLPVEHSSDSPSRPPQTMLGSETIKTPTTHPRAAGRETKYANLSSSSSTASESQLTKPGVIRPVPVKSK
SQ  LLLRKDEEVYEPNPFSKYLEDNSGLFSEQ
//