ID  Q5NCP0;
PN  E3 ubiquitin-protein ligase RNF43;
GN  Rnf43;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Comments: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Nucleus envelope {ECO:0000250}. Note=May be secreted. {ECO:0000250}.
DR  UNIPROT: Q5NCP0;
DR  UNIPROT: B2KGH3;
DR  UNIPROT: Q6DI76;
DR  UNIPROT: Q8BME0;
DR  UNIPROT: Q8C191;
DR  UNIPROT: Q8K0X4;
DR  Pfam: PF13639;
DR  Pfam: PF18212;
DR  PROSITE: PS50089;
DE  Function: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway (PubMed:22895187). Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification (By similarity). {ECO:0000250|UniProtKB:P0DPR2, ECO:0000269|PubMed:22895187}.
DE  Reference Proteome: Yes;
DE  Interaction: Q9EQD0; IntAct: EBI-16007021; Score: 0.40
GO  GO:0005789;
GO  GO:0005887;
GO  GO:0005635;
GO  GO:0005109;
GO  GO:0046872;
GO  GO:0061630;
GO  GO:0004842;
GO  GO:0030178;
GO  GO:0016567;
GO  GO:0072089;
GO  GO:0006511;
GO  GO:0038018;
GO  GO:0016055;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MSGGHQLQLAVLWPWLLMATLHAGFGHTGRVLAAAVESERSAEQKAVIRVIPLKMDPTGKLNLTLEGVFAGVAEVTPAEG
SQ  KLMQSHPLYLCNASDDDNLEPGFISIVKLESPRRAPRPCLSLASKARMAGERGANAVLFDITEDRSAAEQLQQPLGLTKP
SQ  VVLIWGSDAAKLMEFVYKNRKAYVWIELKEPPAGANYDVWILLTVVGTVFVIILASVLRIRCRPHHSRPDPLQQRTARAI
SQ  SQLATRRYQAGCRRARAEWPDSGSSCSSTPVCAICLEEFSEGQELRVISCLHEFHRTCVDPWLYQHRTCPLCMFNIVEGD
SQ  SFSQAPAASPSYQEPGRRLHLIRQHPGHAHYHLPSAYLLGPSRTSVARTPRPRPFLPSQEPSMGSRHQRLPRTSHLRAPE
SQ  EQQHLAVSPHPYAQGWGLNRLRCTSQHPAACPVALRRARPHESSGSGESYCTERSGYLADGPASDSSSGPCHGSSSDSVV
SQ  NCTDVSLQGIHGSSSTFRSSLSSDFDPLVYCSPEGDLQGKGIQPSVTSRPRSLDSVVPRGETQVSSHIHYHRHRHHHYKR
SQ  QFQWHGRKPGPETGIPQSMPAASHTQLEPSLPDQQLITPNPTASSMLPNPQRPRALTEPAPGLAEASSPSPSPKPNPSGL
SQ  LNLQKSSLTVRHPHRKRRGGPSEPLPTSLPPDLTVHTACPVFPHYSPRLAYPWPPEVHPLMFRPPGPDRRLLHEVPGPCY
SQ  SSSQPVWLYLNPCQPLGPCLPGEGHSKWTFDSPEGRRCPYSHCQVLPAQPGSEEELEELCEQAV
//