ID  Q5NVG5;
PN  Synaptosomal-associated protein 25;
GN  SNAP25;
OS  9601;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P60879}. Cell membrane {ECO:0000250|UniProtKB:P60881}; Lipid-anchor {ECO:0000250|UniProtKB:P60879}. Synapse, synaptosome {ECO:0000250|UniProtKB:P60879}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P60879}. Note=Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating at the perinuclear region. Colocalizes with KCNB1 at the cell membrane (By similarity). Colocalizes with PLCL1 at the cell membrane (By similarity). {ECO:0000250|UniProtKB:P60879, ECO:0000250|UniProtKB:P60881}.
DR  UNIPROT: Q5NVG5;
DR  UNIPROT: Q5NVK3;
DR  UNIPROT: Q5R505;
DR  UNIPROT: Q5R690;
DR  UNIPROT: Q5R6U7;
DR  Pfam: PF00835;
DR  PROSITE: PS50192;
DE  Function: t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. {ECO:0000250, ECO:0000250|UniProtKB:P60881}.
DE  Reference Proteome: Yes;
GO  GO:0070161;
GO  GO:0005737;
GO  GO:0016020;
GO  GO:0043005;
GO  GO:0048471;
GO  GO:0001917;
GO  GO:0005886;
GO  GO:0031201;
GO  GO:0045202;
GO  GO:0017075;
GO  GO:0005249;
GO  GO:0006887;
TP  Membrane Topology: Lipid-Anchored; Source: UniProt - By Similarity {ECO:0000250|UniProtKB:P60879};
SQ  MAEDADMRNELEEMQRRADQLADESLESTRRMLQLVEESKDAGIRTLVMLDEQGEQLERIEEGMDQINKDMKEAEKNSTD
SQ  LGKFCGLCVCPCNKLKSSDAYKKAWGNNQDGVVASQPARVVDEREQMAISGGFIRRVTNDARENEMDENLEQVSGIIGNL
SQ  RHMALDMGNEIDTQNRQIDRIMEKADSNKTRIDEANQRATKMLGSG
//