ID  Q5PQX1;
PN  Torsin-1A-interacting protein 1;
GN  Tor1aip1;
OS  10116;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus inner membrane {ECO:0000269|PubMed:16128803, ECO:0000269|PubMed:7721789}; Single-pass membrane protein {ECO:0000269|PubMed:16128803, ECO:0000269|PubMed:7721789}.
DR  UNIPROT: Q5PQX1;
DR  UNIPROT: Q62741;
DR  UNIPROT: Q62754;
DR  Pfam: PF05609;
DE  Function: Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina.
DE  Reference Proteome: Yes;
DE  Interaction: Q9R193; IntAct: EBI-15644460; Score: 0.40
DE  Interaction: P63088; IntAct: EBI-21448628; Score: 0.50
DE  Interaction: P62138; IntAct: EBI-21448632; Score: 0.50
DE  Interaction: P07949; IntAct: EBI-22248708; Score: 0.35
DE  Interaction: P35590; IntAct: EBI-22249141; Score: 0.35
DE  Interaction: P35968; IntAct: EBI-22252438; Score: 0.35
DE  Interaction: O75886; IntAct: EBI-22259612; Score: 0.35
GO  GO:0016021;
GO  GO:0016020;
GO  GO:0005635;
GO  GO:0005637;
GO  GO:0031965;
GO  GO:0005634;
GO  GO:0001671;
GO  GO:0051117;
GO  GO:0008092;
GO  GO:0005521;
GO  GO:0061024;
GO  GO:0071763;
GO  GO:0032781;
GO  GO:0090435;
GO  GO:0034504;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MAGERWRAEGLGEGWAIYVTPRAPIREGRRRLATQNGDGSDAPAYETHPSRHGRREVRFSEEPPEVYGDFEPRAAKERSP
SQ  GERRTPPEKFRSDSAKEEVRESAYNLRSRQRRQRGPQEAEEMKTRRSTRLEQHSQQAQQQLSPATSGRGLRDAQSLSEDR
SQ  GEDEPSSQPVTSQTVSKKTVRTPETSVMSEDPISNLCRPPLRSPRPDASIVQHINPFEEGETEDDLESSYSDVTIRIRSR
SQ  DSVESRDEAAVAAGHHPDSLWGLPHSRGDFTAHENQPSLLPTGCQKNPQEWVEQAVRMRTRMAYNNIQKSDFGNQSPSTS
SQ  RQQAAVQPPDESSVKIKWWLLILVAALAMGIYWFFHTPVVETTAVQEFQNQMKQLQSKYQSQDEKLWKRGTTFLEKHLNS
SQ  SLPRPQPAILLLTAAQDAAEVLKCLSEQIADAYSSFRSVRAIRIDGAGKAAQDSDLVKHEVDQELTDGFRNGQNAAVVHR
SQ  FESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEEQTLEASLGLKEIEEKVRDFLKVKFTSSDTANSYNHMDPDKLNGL
SQ  WSRISHLVLPVQPENALKAGSCL
//