ID  Q5R6J5;
PN  G1/S-specific cyclin-D1;
GN  CCND1;
OS  9601;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus {ECO:0000250|UniProtKB:P24385}. Cytoplasm {ECO:0000250|UniProtKB:P24385}. Nucleus membrane {ECO:0000250|UniProtKB:P24385}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members. {ECO:0000250|UniProtKB:P24385}.
DR  UNIPROT: Q5R6J5;
DR  Pfam: PF02984;
DR  Pfam: PF00134;
DR  PROSITE: PS00292;
DE  Function: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also a substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. {ECO:0000250|UniProtKB:P24385}.
DE  Reference Proteome: Yes;
GO  GO:0005923;
GO  GO:0097128;
GO  GO:0000307;
GO  GO:0005737;
GO  GO:0031965;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0017053;
GO  GO:0016538;
GO  GO:0042826;
GO  GO:0070064;
GO  GO:0004672;
GO  GO:0019901;
GO  GO:0003714;
GO  GO:0051301;
GO  GO:0006974;
GO  GO:0030968;
GO  GO:0045444;
GO  GO:0000082;
GO  GO:0007595;
GO  GO:0097421;
GO  GO:0060749;
GO  GO:0033598;
GO  GO:0031571;
GO  GO:0030857;
GO  GO:0043524;
GO  GO:0000122;
GO  GO:0030182;
GO  GO:0045737;
GO  GO:0010971;
GO  GO:0033601;
GO  GO:0001934;
GO  GO:0006468;
GO  GO:0000320;
GO  GO:0044321;
GO  GO:0070141;
GO  GO:0009410;
GO  GO:0016055;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIVATWMLEVCEEQKCEEEVFPL
SQ  AMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAALTPHDF
SQ  IEHFLSKMPEAEENKQIIRKHAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNSFLSYYRLTRFLSRVIKCD
SQ  PDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI
//