ID  Q5R7H4;
PN  Delta(14)-sterol reductase LBR;
GN  LBR;
OS  9601;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus inner membrane {ECO:0000250|UniProtKB:Q14739}; Multi-pass membrane protein {ECO:0000255}. Nucleus {ECO:0000250|UniProtKB:Q14739}. Cytoplasm {ECO:0000250|UniProtKB:Q14739}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q14739}. Note=Nucleus; nuclear rim. {ECO:0000250|UniProtKB:Q14739}.
DR  UNIPROT: Q5R7H4;
DR  Pfam: PF01222;
DR  Pfam: PF09465;
DR  PROSITE: PS01017;
DR  PROSITE: PS01018;
DE  Function: Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (By similarity). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (By similarity). {ECO:0000250|UniProtKB:Q14739, ECO:0000250|UniProtKB:Q3U9G9}.
DE  Reference Proteome: Yes;
GO  GO:0005737;
GO  GO:0005789;
GO  GO:0016021;
GO  GO:0005637;
GO  GO:0005634;
GO  GO:0050613;
GO  GO:0003677;
GO  GO:0070402;
GO  GO:0006695;
GO  GO:0030223;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MPSRKFADGEVVRGRWPGSSLYYEVEILSHDSASQLYTVKYKDGTELELKENDIKPLTSFRQRKGGSTSSSPSRRRGSRS
SQ  RSRSRSPGRPPKSARRSASASHQADIKEARREVEVKLTPLILKPFGNSISRYNGEPEHIERNDVPHKNTQEKFNLSQESS
SQ  YIATQCSLRPKREEVKLKEIDSKEEKFVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQKDPSL
SQ  LNFPPPLPALYELWETRVFGVYLLWFLIQVVFYLLPIGKVVEGTPLIDGRRLKYRLNGFYAFILTSAVIGTSLFQGVEFH
SQ  YVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPASSGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVIN
SQ  LVMLLAEMKIQDRAVPSLAMILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPN
SQ  EVSWPMASLIIVLKFCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWWGFARHPNYLGDLIMALAWSL
SQ  ACGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWEKYCQRVPYRIFPYIY
//