ID  Q5R9G1;
PN  DCN1-like protein 3;
GN  DCUN1D3;
OS  9601;
SL  Nucleus Position: SL-0198;
SL  Comments: Cell membrane {ECO:0000250|UniProtKB:Q8IWE4}. Cytoplasm {ECO:0000250|UniProtKB:Q8IWE4}. Nucleus {ECO:0000250|UniProtKB:Q8IWE4}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8IWE4}. Note=After UVC treatment, the protein enters to the nucleus gradually. Cell membrane localization is essential for CUL3 neddylation. {ECO:0000250|UniProtKB:Q8IWE4}.
DR  UNIPROT: Q5R9G1;
DR  Pfam: PF03556;
DR  PROSITE: PS51229;
DE  Function: Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and may play a role in the cell cycle progression by regulating the SCF ubiquitin E3 ligase complex, after UV damage. At the cell membrane, can promote and as well inhibit cullins neddylation. {ECO:0000250|UniProtKB:Q8IWE4}.
DE  Reference Proteome: Yes;
GO  GO:0005737;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0097602;
GO  GO:0030308;
GO  GO:2000134;
GO  GO:2000435;
GO  GO:0043065;
GO  GO:2000436;
GO  GO:0010564;
GO  GO:2000434;
GO  GO:0010332;
GO  GO:0010225;
TP  Membrane Topology: Lipid-Anchored; Source: UniProt - By Similarity {ECO:0000250|UniProtKB:Q8IWE4,};
SQ  MGQCVTKCKNPSSTLGSKNGDRDPSNKSHSRRGAGHREEQVPPCGKPGGDILVNGTKKAEAATEACQLPTSSGDAGRESK
SQ  SNAEESSLQRLEELFRRYKDEREDAILEEGMERFCNDLCVDPTEFRVLLLAWKFQAATMCKFTRKEFFDGCKAISADSID
SQ  GICARFPSLLTEAKQEDKFKDLYRFTFQFGLDSEEGQRSLHREIAIALWKLVFTQNNPPVLDQWLNFLTENPSGIKGISR
SQ  DTWNMFLNFTQVIGPDLSNYSEDEAWPSLFDTFVEWEMERRKREGEGRGALSSGPEGLCPEEQT
//