ID  Q5RAP0;
PN  Protein unc-45 homolog A;
GN  UNC45A;
OS  9601;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominant in the perinuclear region. Little protein in the nucleus (By similarity). {ECO:0000250}.
DR  UNIPROT: Q5RAP0;
DR  Pfam: PF13181;
DR  Pfam: PF11701;
DR  PROSITE: PS50005;
DR  PROSITE: PS50293;
DE  Function: May act as co-chaperone for HSP90 (Potential). Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell (By similarity). May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity). {ECO:0000250, ECO:0000305}.
DE  Reference Proteome: Yes;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0030154;
GO  GO:0007517;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MTASSVEQLRKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACYLKLEDYDKAETEASKAIEKDGGDVKAL
SQ  YRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQEKVRYMSSTDAKVEQMFQILLDPEEKGTEKKQKAS
SQ  QNLVVLAREDAGAEKTLRSNGVQLLQRLLDTGETDLMLAALRTLVGICSEHQSRTVATLSILGTRRVVSILGVESQSVSL
SQ  AACHLLQVMFDALKEGVKKGFRGKEGAIIVDPARELKVLISNLLDLLTEVGVSGQGRDNALTLLIKAVPRKSLKDPNNSL
SQ  TLWVIDQGLKKILEVGGSLQDPPGELAVTANSRMSASILLSKLFDDLKCDAERENFHRLCENYIKSWFEGRGLAGKLRAI
SQ  QTVSCLLQGPCDAGNRALELSGVMEGVIALCASEQEEEQLVAVEALIHAAGKAKRASFITANGVSLLKDLYKRSEKDSIR
SQ  IRALVGLCKLGSAGGTDFSMKQFAEGSTLKLAKQCRKWLCNDQIDAGTRRWAVEGLAYLTFDADVKEEFVEDAAALKALF
SQ  QLSRSEERSVLFAVASALVNCTNSYDYEEPDPKMVELAKYAKQHVPEQHPKDKPSFVRARVKKLLAAGVVSAMVYMVKTE
SQ  SPVLTSSCRELLSRIFLALVEEVEDRGTVVAQGGGRALIPLALEGTDVGQTKAAQALAKLTITSNPEMTFPGERIYEVVR
SQ  PLVSLLHLNCSGLQNFEALMALTNLAGISERLRQKILKEKAVPMIEGYMFEEHEMIRRASTECMCNLAMSKEVQDLFEAE
SQ  GNDRLKLLVLYSGEDDELLQRAAAGGLAMLTSMRPTLCSRIPQVTTHWLEILQALLLSSNQELQHRGAVVVLNMVEASRE
SQ  IASTLMESEMMEILSVLAKGDHSPVTRAAAACLDKAVEYGLIQPNQDGE
//