ID  Q5RBR0;
PN  E3 ubiquitin-protein ligase SH3RF1;
GN  SH3RF1;
OS  9601;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q71F54}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q69ZI1}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q69ZI1}. Note=Colocalizes, with AKT2, in lamellipodia. Colocalizes, with HERP1, in trans-Golgi network. {ECO:0000250|UniProtKB:Q69ZI1, ECO:0000250|UniProtKB:Q7Z6J0}.
DR  UNIPROT: Q5RBR0;
DR  Pfam: PF00018;
DR  Pfam: PF14604;
DR  PROSITE: PS50002;
DR  PROSITE: PS00518;
DR  PROSITE: PS50089;
DE  Function: Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin- dependent and clathrin-independent endocytosis. Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F- actin assembly. {ECO:0000250|UniProtKB:Q69ZI1, ECO:0000250|UniProtKB:Q7Z6J0}.
DE  Reference Proteome: Yes;
GO  GO:0005794;
GO  GO:0030027;
GO  GO:0048471;
GO  GO:0005078;
GO  GO:0046872;
GO  GO:0061630;
GO  GO:0001764;
GO  GO:0046330;
GO  GO:0051865;
GO  GO:0043370;
GO  GO:2000564;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSRNELRCPECRTLVGSGVEELPSNILLVRLLDGIKQRP
SQ  WKPGPGGGSGTNCTNALRSQSSTVANCSSKDLQSSQGGQQPRVQAWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDI
SQ  IILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEG
SQ  MLADKIGIFPISYVEFNSAAKQLIEWDKPPVPGVDAGECSSAAAQSSTAPKHSDTKKNTKKRHSFTSLTMANKSSQASQN
SQ  RHSMEISPPVLISSSNPTAAARISELSGLSCSAPSQVHISTTGLIVTPPPSSPVTTGPSFTFPSDVPYQATLGTLNPPLL
SQ  PPPLLAATVLASTPPGAAAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSVYVAIYPYTPRKEDELELRKGEMFLVFERCQD
SQ  GWFKGTSMHTSKIGVFPGNYVAPVTRAVTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPAQKLQGNGVAGSPSVVPTAVV
SQ  SAAHIQTSPQAKVLLHMTGQMTVNQARNAVRTVAAHNQERPTAAVTPIQVQNAAGLSPASVGLPHHSLASPQPAPLMPGS
SQ  ATHTAAISISRASAPLACAAAAPLTSSSITSASLEAEPSGRIVTVLPGLPTSPDSASLACGNSSATKPDKDSKKEKKGLL
SQ  KLLSGASTKRKPRVSPPASPTLEVELGSAELPLHGAVGPELPPGGGHGRAGSCPVDGDGPVTTAVAGAALAQDAFHRKAS
SQ  SLDSAVPIAPPPRQACSSLGPVLNESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLF
SQ  PGSFVENI
//