ID  Q5RI56;
PN  Optineurin;
GN  optn;
OS  7955;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Golgi apparatus {ECO:0000250|UniProtKB:Q96CV9}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Recycling endosome {ECO:0000250}. Cytoplasmic vesicle, autophagosome {ECO:0000250}.
DR  UNIPROT: Q5RI56;
DR  UNIPROT: Q6P3H5;
DR  UNIPROT: Q7SXF4;
DR  Pfam: PF16516;
DR  Pfam: PF11577;
DR  PROSITE: PS51801;
DE  Function: Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. {ECO:0000250, ECO:0000250|UniProtKB:Q96CV9}.
DE  Reference Proteome: Yes;
GO  GO:0005776;
GO  GO:0005737;
GO  GO:0005794;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0055037;
GO  GO:0070530;
GO  GO:0046872;
GO  GO:0006914;
GO  GO:0007409;
GO  GO:0042742;
GO  GO:0090161;
GO  GO:0034067;
GO  GO:0043122;
GO  GO:0051648;
GO  GO:0016192;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MNGDISHPRGSGPGNLGSLEETLQQMNTLIKENRDLKEALKQTNLSMKERFEGLSAWKEKQKEERDFLEQRLEEARTRLN
SQ  TMDVENEALKNQVKELEKSGAECLHTELEALRGQILRIQAEKNDLVAMNSELQLKMGQGSPSNSFIEIRIADDDLKVTKD
SQ  LSSVPEASAFSMPKAESEEQTVRQLLRSLRAETDEKERLQLTLQEARGRIAELESKLEHADSSAQTSLPSAAETNASTEV
SQ  KNLEDQLLKLCNELKQAQIKLDEAESMKRNLQDRCKDLEQDLGTLKTQLGDKQKVQAENDCLKVQMESLQAAIKLEQKKT
SQ  QDEKNNLNQLKDAYTKLFEDYSELQEEKKKRESCVSKDDYDELQTRFATAEKALADKQQKIDEMKMELFQKEKDLETISV
SQ  FQAQAEIYSSDFYAERAAREKIHEEKERLATQLEYVKKQNSQLQEEMESLGRHSMSEMQRRHVPRGANPQGPTAPNNLPG
SQ  GRGEWQQQNIPDHACPKCGEVLPDLDSLQIHIMDCII
//