ID  Q5RK09;
PN  Eukaryotic translation initiation factor 3 subunit G;
GN  Eif3g;
OS  10116;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03006}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03006}. Cytoplasm, perinuclear region {ECO:0000255|HAMAP-Rule:MF_03006}. Note=Colocalizes with AIFM1 in the nucleus and perinuclear region. {ECO:0000255|HAMAP- Rule:MF_03006}.
DR  UNIPROT: Q5RK09;
DR  Pfam: PF12353;
DR  Pfam: PF00076;
DR  PROSITE: PS50102;
DE  Function: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA. {ECO:0000255|HAMAP-Rule:MF_03006}.
DE  Reference Proteome: Yes;
DE  Interaction: P09619; IntAct: EBI-22247316; Score: 0.35
DE  Interaction: Q9H5Y7; IntAct: EBI-22259307; Score: 0.35
GO  GO:0005737;
GO  GO:0016282;
GO  GO:0033290;
GO  GO:0005852;
GO  GO:0048471;
GO  GO:0003723;
GO  GO:0003743;
GO  GO:0001732;
GO  GO:0006413;
GO  GO:0075525;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MPTGDFDSKPSWADQVEEEGEDDKCVTSELLKGIPLPTGDTSPEPELLPGDPLPPPKEVINGNIKTVTEYKVEEDGKKFK
SQ  IVRTFRIETRKASKAVARRKNWKKFGNSEFDPPGPNVATTTVSDDVSMTFITSKEDLNCQEEEDPMNKLKGQKIVSCRIC
SQ  KGDHWTTRCPYKDTLGPMQKELAEQLGLSTGEKEKLPGELEPVQAAQNKTGKYVPPSLRDGASRRGESMQPNRRADDNAT
SQ  IRVTNLSEDTRETDLQELFRPFGSISRIYLAKDKTTGQSKGFAFISFHRREDAARAIAGVSGFGYDHLILNVEWAKPSTN
//