ID  Q5SNT2;
PN  Transmembrane protein 201;
GN  TMEM201;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Comments: [Isoform 2]: Nucleus inner membrane {ECO:0000269|PubMed:19494128, ECO:0000269|PubMed:21610090}; Multi-pass membrane protein {ECO:0000269|PubMed:19494128}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:19494128}. Note=The C- terminal of isoform 2 is located on the nucleoplasmic side. During interphase, isoform 2 is distributed in the inner nuclear membrane in distinct micro-domains and during mitosis, it is found in the ER but it also localizes to the polar regions of the mitotic spindle. {ECO:0000269|PubMed:19494128, ECO:0000269|PubMed:21610090}.
DR  UNIPROT: Q5SNT2;
DR  UNIPROT: B9EH90;
DR  UNIPROT: Q5SNT3;
DR  Pfam: PF10476;
DR  Pfam: PF09779;
DR  DisGeNET: 199953;
DE  Function: Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin-dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860). {ECO:0000250|UniProtKB:A2A8U2, ECO:0000305|PubMed:27541860}. [Isoform 2]: May define a distinct membrane domain in the vicinity of the mitotic spindle (PubMed:19494128). Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina (PubMed:21610090). {ECO:0000269|PubMed:19494128, ECO:0000269|PubMed:21610090}.
DE  Reference Proteome: Yes;
DE  Interaction: P50402; IntAct: EBI-24476865; Score: 0.68
DE  Interaction: P57078; IntAct: EBI-12503575; Score: 0.35
DE  Interaction: P61021; IntAct: EBI-11012076; Score: 0.35
DE  Interaction: Q8N3V7; IntAct: EBI-11086992; Score: 0.35
DE  Interaction: Q9UPX6; IntAct: EBI-24314531; Score: 0.56
DE  Interaction: Q6ZS10; IntAct: EBI-24353816; Score: 0.56
DE  Interaction: Q969F0; IntAct: EBI-25247063; Score: 0.56
DE  Interaction: Q9GZY8; IntAct: EBI-24366218; Score: 0.56
DE  Interaction: Q96KC8; IntAct: EBI-24662993; Score: 0.56
DE  Interaction: Q53FP2; IntAct: EBI-24683073; Score: 0.56
DE  Interaction: Q9Y320; IntAct: EBI-24688407; Score: 0.56
DE  Interaction: P00387; IntAct: EBI-24711951; Score: 0.56
DE  Interaction: Q96Q45; IntAct: EBI-24728264; Score: 0.56
DE  Interaction: Q8N386; IntAct: EBI-24756168; Score: 0.56
DE  Interaction: Q8N183; IntAct: EBI-25279841; Score: 0.56
DE  Interaction: P54829; IntAct: EBI-24436921; Score: 0.56
DE  Interaction: Q92806; IntAct: EBI-24535389; Score: 0.56
DE  Interaction: A2A2Y4; IntAct: EBI-24594602; Score: 0.56
DE  Interaction: Q9BXS9; IntAct: EBI-24638495; Score: 0.56
DE  Interaction: Q8TAF8; IntAct: EBI-24658961; Score: 0.56
DE  Interaction: Q8TDT2; IntAct: EBI-24759602; Score: 0.56
DE  Interaction: Q7Z7G2; IntAct: EBI-24799219; Score: 0.56
DE  Interaction: P20036; IntAct: EBI-21511890; Score: 0.35
DE  Interaction: O15482; IntAct: EBI-21523851; Score: 0.35
DE  Interaction: Q8NBM4; IntAct: EBI-25771384; Score: 0.35
DE  Interaction: O60285; IntAct: EBI-28931176; Score: 0.35
DE  Interaction: Q6J9G0; IntAct: EBI-28941708; Score: 0.35
DE  Interaction: Q8NCK7; IntAct: EBI-27103180; Score: 0.35
DE  Interaction: Q9UM73; IntAct: EBI-32717464; Score: 0.42
DE  Interaction: O15146; IntAct: EBI-32724025; Score: 0.27
GO  GO:0005737;
GO  GO:0005639;
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0000922;
GO  GO:0051015;
GO  GO:0005521;
GO  GO:0051642;
GO  GO:0010761;
GO  GO:0006998;
GO  GO:0030473;
GO  GO:0090435;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MEGVSALLARCPTAGLAGGLGVTACAAAGVLLYRIARRMKPTHTMVNCWFCNQDTLVPYGNRNCWDCPHCEQYNGFQENG
SQ  DYNKPIPAQYLEHLNHVVSSAPSLRDPSQPQQWVSSQVLLCKRCNHHQTTKIKQLAAFAPREEGRYDEEVEVYRHHLEQM
SQ  YKLCRPCQAAVEYYIKHQNRQLRALLLSHQFKRREADQTHAQNFSSAVKSPVQVILLRALAFLACAFLLTTALYGASGHF
SQ  APGTTVPLALPPGGNGSATPDNGTTPGAEGWRQLLGLLPEHMAEKLCEAWAFGQSHQTGVVALGLLTCLLAMLLAGRIRL
SQ  RRIDAFCTCLWALLLGLHLAEQHLQAASPSWLDTLKFSTTSLCCLVGFTAAVATRKATGPRRFRPRRFFPGDSAGLFPTS
SQ  PSLAIPHPSVGGSPASLFIPSPPSFLPLANQQLFRSPRRTSPSSLPGRLSRALSLGTIPSLTRADSGYLFSGSRPPSQVS
SQ  RSGEFPVSDYFSLLSGSCPSSPLPSPAPSVAGSVASSSGSLRHRRPLISPARLNLKGQKLLLFPSPPGEAPTTPSSSDEH
SQ  SPHNGSLFTMEPPHVPRKPPLQDVKHALDLRSKLERGSACSNRSIKKEDDSSQSSTCVVDTTTRGCSEEAATWRGRFGPS
SQ  LVRGLLAVSLAANALFTSVFLYQSLR
//