ID  Q5SQX6;
PN  Cytoplasmic FMR1-interacting protein 2;
GN  Cyfip2;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:11438699}. Nucleus {ECO:0000250|UniProtKB:Q96F07}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11438699}. Synapse, synaptosome {ECO:0000269|PubMed:11438699}. Note=Highly expressed in the perinuclear region and enriched in synaptosomes (PubMed:11438699). {ECO:0000269|PubMed:11438699}.
DR  UNIPROT: Q5SQX6;
DR  UNIPROT: Q3UH21;
DR  UNIPROT: Q3UHS8;
DR  UNIPROT: Q8BSW0;
DR  UNIPROT: Q8CHA9;
DR  UNIPROT: Q924D3;
DR  UNIPROT: Q9R181;
DR  Pfam: PF07159;
DR  Pfam: PF05994;
DE  Function: Part of the WAVE1 complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). Involved in T-cell adhesion and p53-dependent induction of apoptosis (By similarity). Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (PubMed:27605705). {ECO:0000250|UniProtKB:Q96F07, ECO:0000269|PubMed:11438699, ECO:0000269|PubMed:27605705}.
DE  Reference Proteome: Yes;
DE  Interaction: P05783; IntAct: EBI-16086797; Score: 0.35
DE  Interaction: P35922; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: Q03001; IntAct: EBI-16086797; Score: 0.35
DE  Interaction: Q62108; IntAct: EBI-2307988; Score: 0.53
DE  Interaction: Q8CBW3; IntAct: EBI-2642480; Score: 0.53
DE  Interaction: P50516; IntAct: EBI-6272793; Score: 0.35
DE  Interaction: Q8BPN8; IntAct: EBI-6272767; Score: 0.35
DE  Interaction: Q9Y2A7; IntAct: EBI-16086775; Score: 0.35
DE  Interaction: Q8WUW1; IntAct: EBI-16086775; Score: 0.35
DE  Interaction: Q9NYB9; IntAct: EBI-16086775; Score: 0.35
DE  Interaction: Q92558; IntAct: EBI-16086775; Score: 0.35
DE  Interaction: Q5SYE7; IntAct: EBI-16086797; Score: 0.35
DE  Interaction: Q92614; IntAct: EBI-16086797; Score: 0.35
DE  Interaction: Q3ZCQ8; IntAct: EBI-16086797; Score: 0.35
DE  Interaction: O14735; IntAct: EBI-16086797; Score: 0.35
DE  Interaction: P13796; IntAct: EBI-16086797; Score: 0.35
DE  Interaction: Q9UHB6; IntAct: EBI-16086797; Score: 0.35
DE  Interaction: O00443; IntAct: EBI-16086797; Score: 0.35
DE  Interaction: P16615; IntAct: EBI-16086797; Score: 0.35
DE  Interaction: P05787; IntAct: EBI-16086797; Score: 0.35
DE  Interaction: Q9Y6W5; IntAct: EBI-16086797; Score: 0.35
DE  Interaction: Q9UPY6; IntAct: EBI-16086797; Score: 0.35
DE  Interaction: P08727; IntAct: EBI-16086797; Score: 0.35
DE  Interaction: Q7L576; IntAct: EBI-16086797; Score: 0.35
DE  Interaction: Q7TMB8; IntAct: EBI-16727444; Score: 0.35
DE  Interaction: Q7TPH6; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: Q64514; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: P83510; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: Q4ACU6; IntAct: EBI-16727864; Score: 0.50
DE  Interaction: D3YZU1; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: Q8BYM5; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: P17426; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: Q8R5H6; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: Q812A2; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: Q68FG2; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: Q62261; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: P16546; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: A2AQ25; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: Q8C437; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: B1AXH1; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: Q8K1R7; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: P28660; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: Q99104; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: O35099; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: Q08460; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: P46660; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: Q8VDC1; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: P39053; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: B9EJA2; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: Q02248; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: O54991; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: P15116; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: P70408; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: Q6P9K8; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: P28652; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: P11798; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: Q8K3H0; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: P62484; IntAct: EBI-16727864; Score: 0.35
DE  Interaction: Q9EP53; IntAct: EBI-16734894; Score: 0.35
DE  Interaction: Q9D415; IntAct: EBI-16725590; Score: 0.35
DE  Interaction: Q3UHD9; IntAct: EBI-16736255; Score: 0.35
DE  Interaction: F6SEU4; IntAct: EBI-16737600; Score: 0.35
GO  GO:0070161;
GO  GO:0005737;
GO  GO:0043005;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0031209;
GO  GO:0045202;
GO  GO:0031267;
GO  GO:0097202;
GO  GO:0006915;
GO  GO:0000902;
GO  GO:0098609;
GO  GO:0097484;
GO  GO:0031175;
GO  GO:0051388;
GO  GO:0045862;
GO  GO:0030833;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYIEQATVHSSMNEMLEEGHDYA
SQ  VMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLT
SQ  LGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLAD
SQ  IVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFKQLQVVPLFGDMQIELARYIK
SQ  TSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFISELARYSNSEVVTGSGLDSQKSDEEYRELFDLALRGLQLL
SQ  SKWSAHVMEVYSWKLVHPTDKFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTIY
SQ  AALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKGGFDIKVPRRAVGPSSTQLYM
SQ  VRTMLESLIADKSGSKKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRIQFPIE
SQ  MSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKAMAGSV
SQ  LLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQLLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWL
SQ  LEINRLTHRLLCKHMTLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQRDKPA
SQ  NVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKIVKSLLQGTILQYVKTLIEVMPKICR
SQ  LPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQSLREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGE
SQ  RLEVRMKRLEAKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTNGVMHV
SQ  DECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDLFDFCYHLLKVQRQDGKDEIIKNVPL
SQ  KKMADRIRKYQILNNEVFAILNKYMKSVETDSSTVEHVRCFQPPIHQSLATTC
//